Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice by Jung Hun Ohn (10089)

“…After 12 weeks of high fat diet (HFD), SHP KO mice gained less weight and exhibited less elevation in serum-free fatty acid and less ectopic lipid accumulation in the myocardium than WT mice. According to microarray analysis, genes regulated by PPARγ1 and PPARα were down-regulated in myocardia of SHP KO mice compared to their expression in WT mice after HFD, suggesting that the reduction in lipid accumulation in the myocardium resulted from a decrease in lipogenesis regulated by PPARγ. …”

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress by Mengli Zhang (6331172)

“…As a result, SIRT5 deficiency decreases mitochondrial ATP production, increases AMP/ATP ratio, and subsequently activates AMP-activated protein kinase (AMPK) in cultured cells and mouse hearts under energy stress conditions. …”

MiR-145-5p inhibition rescues ROCK1 expression following OIP5-AS1 silencing in I/R Injury. by Jingyan Yang (7120994)

SIRT5 KO leads to increased AMP/ATP ratio and AMPK activation in HEK293T cells. by Mengli Zhang (6331172)

In vivo-determined rates of protein synthesis in gastrocnemius, heart and liver of male and female WT and 4E-BP1/BP2 DKO mice. by Jennifer L. Steiner (580144)

NOD2-mediated Suppression of CD55 on Neutrophils Enhances C5a Generation During Polymicrobial Sepsis by Sae Jin Oh (135988)

“…Injection of recombinant C5a decreased survival rates of Nod2^−/− mice rate during sepsis, whereas it did not alter those in wild type mice. …”

Sirt5 KO leads to increased AMP/ATP ratio and AMPK activation in mouse hearts. by Mengli Zhang (6331172)

Characterization of optogenetically-evoked DA dynamics as a square wave dip. by Hidetoshi Urakubo (578508)

Loss of <i>CDK8</i> decreased the elevated RNAPII-CTD S₅ phosphorylation levels at Ty1 retrotransposons observed in the <i>rpb1-CTD11</i> mutant. by Maria J. Aristizabal (451648)

Immunofluorescent staining with vWF. by Jae Heon Kim (10454261)

“…<p>Immunofluorescent staining with vWF showed a decrease in the number of vWF-positive cells in the group with BOO and an increase in vWF-positive cells after transplantation of hMSCs. …”

Baseline identification of clonal V(D)J sequences for DNA-based minimal residual disease detection in multiple myeloma by Even H. Rustad (6499169)

“…As a molecular control for tumor cell content, we sequenced the samples using our in-house myeloma panel myTYPE. …”

Cytokine (IL-4 and IL-13) concentrations in BAL fluid of mice fed (n-3) or (n-6) PUFA enriched foods for 8 weeks and then sensitized and challenged with OVA for an additional 4 wee... by Jean A. Hall (289030)

Percent of lung tissue staining positive with periodic acid-Schiff (PAS) stain for mucus and rat anti-mouse CD45 stain, after mice were fed (n-3) or (n-6) PUFA enriched foods for 8... by Jean A. Hall (289030)

Average nutrient composition (dry matter basis) of diets fed to mice for 12 weeks. by Jean A. Hall (289030)

BAL fluid cytology proportions for mice fed (n-3) or (n-6) PUFA enriched foods for 8 weeks and then sensitized and challenged with OVA for an additional 4 weeks compared with mice... by Jean A. Hall (289030)

Representative light microscopy images of lung tissue. by Jean A. Hall (289030)

Time line for the experimental protocol. by Jean A. Hall (289030)

Representative light microscopy images of lung tissue. by Jean A. Hall (289030)

Composition of selected FA in diets fed to mice for 12 weeks. by Jean A. Hall (289030)

Plasma concentrations (g/100 g FA) of selected FA in mice after dietary intervention for 12 weeks¹. by Jean A. Hall (289030)