Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study by Laura K. Erdman (355452)

“…Classification and Regression Tree analysis generated multi-marker models with improved performance over single markers for discriminating between groups. A model based on C-reactive protein and Chitinase 3-like-1 discriminated between end-point pneumonia and non-end-point pneumonia with 93.3% sensitivity (95% confidence interval 76.5–98.8), 80.8% specificity (72.6–87.1), positive likelihood ratio 4.9 (3.4–7.1), negative likelihood ratio 0.083 (0.022–0.32), and misclassification rate 0.20 (standard error 0.038).…”

Effects of α-syn expression on 20/26S proteasomal activity in living SH-SY5Y cells. by Lisa Zondler (3405464)

“…<p>A cellular 20/26S proteasome assay implementing SH-SY5Y cells that stably express wild-type or A53T α-syn as well as a mock control was performed to assess the effect of the presence of α-syn on proteasomal activity on a neuronal background. …”

Protective Efficacy of Cross-Reactive CD8⁺ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold by Sophie A. Valkenburg (176257)

“…The engineered virus induced a diminished CD8⁺ T cell response and selected a narrowed T cell receptor (TCR) repertoire within two Vβ regions (Vβ8.3 and Vβ9). …”

Mutation of the metal coordination sites of HypA results in decreased hydrogenase activity. by Faith C. Blum (4357027)

Image_1_Eph-ephrin Signaling Affects Eye Lens Fiber Cell Intracellular Voltage and Membrane Conductance.TIF by Catherine Cheng (114496)

“…Recent studies have revealed that disruption of Eph-ephrin signaling, in particular the receptor EphA2 and the ligand ephrin-A5, in humans and mice lead to congenital and age-related cataracts. …”

Simulated effects of increased pCREB combined with decreased pCaMKIIα on time courses of molecular pathways and synaptic weight W after IA training. by Yili Zhang (540283)

“…(B) Example of dynamics of BDNF protein/mRNA (B1-2), C/EBPβ protein (B3), pCREB (B4), pCaMKIIα (B5), Sin3a binding (B6), MeCP2 binding (B7), HDAC2 binding (B8), and W (B9), with the standard parameter values in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010239#pcbi.1010239.t001" target="_blank">Table 1</a> (black dashed) or with <i>k</i>_{<i>basalp_creb</i>} increased by ~50% and <i>k</i>_{<i>basalp_CaMKII</i>} decreased by ~50% from control combined with higher binding levels of MeCP2, Sin3a and HDAC2 (blue) to simulate IA conditioning in infant rats. …”

The influence of the controlled pH conditions at the sample preparation step on the obtained signals (panel A: extraction using a mixture of MeOH and EtOH; panel B: extraction usin... by Ewa Paszkowska (21246702)

Image_5_Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1.TIF by Li Zhang (8200)

(a) Changes of exchangeable Ca²⁺ content during acification of black soil. (b) Changes of exchangeable Mg²⁺ content during acification of black soil. The cont... by Xiaoxu Zhu (11764430)

The five-criterion used to determine cluster partition choice. by Tsaone Tamuhla (10765853)

Average blood pressure measurements and 95% confidence stripes by use of antihypertensive medications and survey year. by Diego Montano (4377373)

Defects in RNA-mediated TDP-43 self-assembly decrease nuclear localization. by Patricia M. dos Passos (18078809)

Average blood pressure measurements by use of antihypertensive medications and respondents’ age. by Diego Montano (4377373)

Efficient down-regulation of Jarid1A is associated with global increase of H3K4me3. by Corina Penterling (2814208)

Percent of mice being guided to escape hole on training days decreased with training. by Aida Attar (170689)

Adjusted odds ratios and 95% confidence intervals for the association of pancreatic cancer with a 1 kg/m2 decrease in body mass index (BMI) between cases and controls (blue circles) and a 1 mmol/mol increase in glycated haemoglobin (HbA1c) (green squares) from 5 years before pancreatic cancer diagnosis. by Agnieszka Lemanska (13911532)

The (A) logistic regression model (LRM) and (B) random forest model (RFM) with only conservation scores as independent variables (orange, yellow) show decreased model fitting metri... by Bushra Haque (20513785)

Cytokine Profiles and the Differentiation of Treg Cells Measured by Mesenteric Lymph Nodes Isolated from <i>T</i>. <i>spiralis</i> Infected Mice. by Xi-Meng Sun (17721428)

Image_5.TIF by Ellen A. G. Chernoff (388800)

Decreased Sho protein levels in the brain during experimental and natural prion disease. by Joel C. Watts (195735)

“…<p>(<b>A</b>) Western blot analysis of Sho protein levels in the brains of clinically ill wt CD-1 mice and meadow voles infected with RML prions. …”