Clinical and genetic characteristics of 5 patients harboring mutations in the <i>NR5A1</i> gene. by Jana Malikova (615672)

Subjects:

Image_1_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg by Mohamed Khass (695111)

“…The trabecular bone volume over total volume (BV/TV) in J_H^-/- mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5^-/- and J_H^-/-λ5^-/- mice demonstrated a severe decrease in trabecular bone mass. …”

Image_1_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg by Mohamed Khass (695111)

“…The trabecular bone volume over total volume (BV/TV) in J_H^-/- mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5^-/- and J_H^-/-λ5^-/- mice demonstrated a severe decrease in trabecular bone mass. …”

PARP inhibition causes a decrease in Alt-EJ that is enhanced by Ku70 loss. by Sean M. Howard (687174)

“…<p>(<b>A</b>) PARPi treatment (Olaparib) causes a specific decrease in Alt-EJ, compared to Distal EJ. …”

Characterization of safety pharmacology of WT BMP9 in rats. by Tobias G. Schips (21799838)

Subjects:

Pretreatment of β-cells with recombinant CXCL12 improves viability and induces a decrease in PARP-1 activity. by Nevena Grdović (394542)

Increased reactive oxygen species (ROS) production and decreased mitochondrial membrane potential in <i>Tet-mev-1</i> hepatocytes. by Tadashi Moro (844328)

Stat1 prevents the decrease of p27^Kip1 by activated Ras. by Shuo Wang (143908)

Deficiency in ArgEF or CpcA but not ArgB decreases the cellular ornithine content. by Nicola Beckmann (194193)

Decreased proliferation and increased apoptosis in <i>Mab21l2</i> mutant embryos. by Yohei Saito (180130)

“…Scale bars represent 100 µm (A, D, H, K) and 50 µm (N and P). (R) Quantitative RT-PCR for genes regulating cell proliferation and apoptosis (<i>N-myc</i>, <i>Id2</i>, <i>Cyclin D1</i>, <i>Cyclin D2</i>), marker genes of myocardial differentiation (<i>Anf</i>, <i>Chisel</i>, <i>Mlc2v</i>), genes essential for the development of the trabecular myocardium (<i>Erbb2</i>, <i>Erbb4</i>, <i>Bmp10</i>), genes essential for heart development (<i>Nkx2.5</i>, <i>Gata4</i>), and endocardial transcripts (<i>Flk1</i>, <i>Tie1</i>, <i>Tie2</i>) normalized to <i>Gapdh</i> expression using RNA from dissected hearts of E11.5 WT and <i>Mab21l2</i> mutant (−/−) embryos. …”

MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1 by FeiYan Xie (4503430)

“…Ectopic miR-193a overexpression inhibited the proliferation, colony formation, migration, and invasion of MDA-MB-231 and BT549 cells. miR-193a reduced Wilms’ tumor 1 (<i>WT1</i>) expression and repressed luciferase reporter activity by binding <i>WT1</i> coding region sequences; mutation of the predicted miR-193a binding site abolished this effect. miR-193a and <i>WT1</i> expression were significantly inversely correlated in breast cancer tissues. …”

PGRN deletion decreased the susceptibility to invasive <i>C</i>.<i>albicans</i> infection in mice. by Jiayu Liu (3951515)

Decreased growth rate and lack of tunicamycin sensitivity of <i>ΔgbcO</i> mutant. by Élise Caliot (158922)

Genes regulated by IRF7 and STAT1 that are upregulated in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

MIF expression in the primary tumor leads to decreased dendritic cell abundance and activation in the tumor. by Kristen N. Balogh (5334764)

Activating cAMP synthesis decreases liberation of propionyl-CoA from cholesterol. by Kaley M. Wilburn (12060476)

Decreased cellular iron uptake increases the <i>P</i>. <i>chabaudi</i> pathogen burden. by Sarah K. Wideman (17118275)

Loss of primary cilia and decreased nephron number in mice with Tamoxifen-induced <i>Kif3a</i> deficiency. by Lijun Chi (196000)

“…The number of precursors is decreased in <i>Kif3a™</i> mice (G) compared to WT mice (F). …”

The loss of Tor1 decreases, and Tor2 inhibition and nitrogen depletion increases, <i>isp5</i>⁺ promoter activity. by Yan Ma (88810)

Pharmacological characterization of WT BMP9 and A347E variant <i>in vitro</i> and <i>in vivo.</i> by Tobias G. Schips (21799838)

Subjects: