Image_1_The impact of the COVID-19 pandemic in diabetes and dyslipidemia management in a Spanish region: a retrospective study of the Aragon population.JPEG by Rocio Mateo-Gallego (16499799)

“…</p>Results<p>Out of the total population of 1,330,000 in the Aragon region, 90,000 subjects were diagnosed with T2D each year, resulting in a prevalence of approximately 7%. The COVID-19 pandemic resulted in a decrease in the prevalence of this disease and a lower incidence during the year 2020. …”

Table_1_The impact of the COVID-19 pandemic in diabetes and dyslipidemia management in a Spanish region: a retrospective study of the Aragon population.DOCX by Rocio Mateo-Gallego (16499799)

“…</p>Results<p>Out of the total population of 1,330,000 in the Aragon region, 90,000 subjects were diagnosed with T2D each year, resulting in a prevalence of approximately 7%. The COVID-19 pandemic resulted in a decrease in the prevalence of this disease and a lower incidence during the year 2020. …”

Image_1_LncRNA KASRT Serves as a Potential Treatment Target by Regulating SRSF1-Related KLF6 Alternative Splicing and the P21/CCND1 Pathway in Osteosarcoma: An In Vitro and In Vivo... by Kai Chen (129938)

“…In vivo experiments further validated that lnc-KASRT enhanced tumor growth and reduced tumor apoptosis; meanwhile, it also increased tumor KLF6-SV1, MMP-1, and MMP-9 expressions but decreased tumor SRSF1 and KLF6-WT expressions in xenograft mice.…”

Table_1_LncRNA KASRT Serves as a Potential Treatment Target by Regulating SRSF1-Related KLF6 Alternative Splicing and the P21/CCND1 Pathway in Osteosarcoma: An In Vitro and In Vivo... by Kai Chen (129938)

“…In vivo experiments further validated that lnc-KASRT enhanced tumor growth and reduced tumor apoptosis; meanwhile, it also increased tumor KLF6-SV1, MMP-1, and MMP-9 expressions but decreased tumor SRSF1 and KLF6-WT expressions in xenograft mice.…”

A case with Chiari malformation 2 diagnosed with vertigo by Zeynep Özözen Ayas (6840431)

“…Symptoms occurs as a results of pressure on the cerebellum like as vertigo, ataxia, vision problems, headache. …”

The primary cortical neurons from E16 homozygous knock out embryos for Egr1 do not respond to sAPPs. by Stéphanie Chasseigneaux (231744)

“…<p>150 nM sAPP-Fc or sAPPβ were added on 1DIV primary neurons from Egr1 wild type (WT), heterozygous (HT) and homozygous (KO) embryos. …”

Galectin‑9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix by Dharma Pally (7216271)

Experimental and Theoretical Studies on the Platinum-Mediated Selective C(sp)–Si Bond Cleavage of Alkynylsilanes by Yasuhiro Okuda (1591588)

“…In comparison, Hammett plots show that C­(sp)–Si bond cleavage rates are accelerated by electron-rich alkynylsilanes, which is opposite to the ordinary oxidative addition of aryl halides to transition metals often observed in catalytic cross-coupling reactions. A DFT calculation reveals that intermediates and transition states are stabilized by electron-rich alkynylsilanes and that the five-membered hemilabile P–N ligand is essential, in which a reactive electron-deficient 14-electron platinum(0) species is produced via the dissociation of nitrogen, giving rise to a monodentate phosphine coordination. …”

Hormonal regulation of structural changes in Sema4D and Plexin-B1. by Takuji Ito (566032)

“…<p>(A–D) To investigate whether estrogen induces structural changes in Sema4D, Plexin-B1, or both, ovariectomized mice receive daily subcutaneous injections (s.c.) of 17β-estradiol (E2, 0.1 µg/kg) until 5 weeks after birth. …”

Loss of function mutations in essential genes cause embryonic lethality in pigs by Martijn F. L. Derks (5348063)

“…The lethal haplotypes have a large effect on carrier-by-carrier matings, decreasing litter sizes by 15.1 to 21.6%. …”

NASH scoring criteria. by Winston T. Stauffer (18086483)

“…We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease in mice under the western-diet and carbon tetrachloride (CCl₄) non-alcoholic steatohepatitis (NASH) model. …”

Simulation results for a network with leftward shifted STDP. by Baktash Babadi (359969)

“…</b> The steady-state mean synaptic weight as a function of the initial rate. …”

A Polymorphism (rs2295080) in <i>mTOR</i> Promoter Region and Its Association with Gastric Cancer in a Chinese Population by Ming Xu (151206)

“…Meanwhile, GC patients carrying TG/GG genotype also displayed a decreased mRNA level of <i>mTOR</i> (<i>P</i> = 0.004). …”

Putative PPT1 substrates are enriched at the synapse and display persistent palmitoylation. by Erica L. Gorenberg (12329728)

“…A total of 11 proteins are significantly differentially expressed (1 decrease (PPT1); 10 increase; 1.5-fold, <i>p</i> < 0.05; blue lines; <b><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001590#pbio.3001590.s001" target="_blank">S1 Data</a></b>). …”

Image_1_Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington’s disease.tif by Emanuela Paldino (499905)

“…We found that activated SHP-1 was present in microglia and neurons of WT mice at 5 and 13 weeks, increasing with time; while in R6/2 it was not localized in neurons but only in microglia, where it decreases with time. …”

Image_2_Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington’s disease.tif by Emanuela Paldino (499905)

“…We found that activated SHP-1 was present in microglia and neurons of WT mice at 5 and 13 weeks, increasing with time; while in R6/2 it was not localized in neurons but only in microglia, where it decreases with time. …”

Video_1_Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma.MOV by Thomas Mignan (14805745)

“…<p>A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink. …”

Deconvolution shows a strong effect of cell subtype proportions on gene expression variation in a study of blood leukocytes from asthmatics. by Yu Kong (487122)

“…(c) Looking into why the cell subtypes were so influential in altering gene expression, we find the proportions of two cell types to be significantly different in patients with severe asthma, an increased proportion of neutrophils (p = 0.021, Mann-Whitney test) and a decreased proportion of CD8+ T cells (p = 0.072, Mann-Whitney test). …”

KChIP2 knock down attenuates <i>I</i>_<i>Na</i> density. by Drew M. Nassal (845780)

“…Right panel shows the average fold change from KChIP2 KD treated cardiomyocytes from control, which resulted in significantly decreased expression following KChIP2 KD (n = 3). Data presented as mean ± SEM; <i>*P</i> < 0.05 two-tailed Student’s <i>t</i>-test performed for I/V plot, paired two-tailed Student’s <i>t</i>-test performed for Western blot.…”

A sequence of photographs documenting I/R-induced injury in the microcirculation of a control hamster in the baseline condition (a), within 30 min of ischemia (b), 10 min (c) and 3... by Silva Bertuglia (54760)