Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…Here, we proposed the concept of “nonbioavailable substructures”, referring to substructures that are unfavorable to bioavailability. A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

mGluR5 biases different intracellular pathways in iSPNs and dSPNs to regulate DLS t-LTD. by Vincent Paget-Blanc (21807763)

Effect of <i>CrBV3-31</i> interference on the performance of <i>Cotesia ruficrus</i> offspring. by Xian Li (201841)

Concentrations of 5-HT and 5-HIAA in brain tissue. by Thibault Renoir (348572)

“…Both 5-HT and 5-HIAA concentrations were decreased in the hippocampus (A/B), the cortex (C/D) and the striatum (E/F) in female HD mice when compared to WT animals. …”

Descriptive statistics and bivariate correlations. by Betty Henderson-Matthews (21539999)

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology by Laurence J. Howe (5579186)

“…Where evidence was found of genetic overlap, we used bidirectional Mendelian randomization (MR) to test the hypothesis that genetic liability to nsCL/P is causally related to implicated facial phenotypes. Across 5,804 individuals of European ancestry from two studies, we found strong evidence, using PRS, of genetic overlap between nsCL/P and philtrum width; a 1 S.D. increase in nsCL/P PRS was associated with a 0.10 mm decrease in philtrum width (95% C.I. 0.054, 0.146; P = 2x10^-5). …”

Marker expression and fluorescence intensity in oral epithelium biopsies. by Zahra Abdalla (4669927)

Summary of hierarchical linear regression model with spirituality predicting symptoms of anxiety. by Betty Henderson-Matthews (21539999)

Summary of hierarchical linear regression model with spirituality predicting loneliness. by Betty Henderson-Matthews (21539999)

Summary of hierarchical linear regression model with spirituality predicting symptoms of depression. by Betty Henderson-Matthews (21539999)

VEGF overexpression in OU culture increased OU size and altered stem/progenitor cell gene expression. by Christopher R. Schlieve (3179439)

“…(C) Significant increase in Bmi1 and Atoh1 expression and decrease in EphB2 expression was observed in doxycycline-treated VEGF OU compared to controls at 5 days (*p<0.05). …”

(a) Schematic of the sample preparation, (b) developed GFRPs samples modified, (c) samples for impact strength tests, (d) samples for compressive strength tests. by Shaban Gul (14309526)

Comparison of marker expression in abnormal tissue compared to normal epithelium. by Zahra Abdalla (4669927)

Determination of cellular localisation and fluorescence intensity of marker expression in oral epithelium biopsies. by Zahra Abdalla (4669927)

sFlt-1 mutant mice demonstrated increased lysozyme-positive cells per hemicrypt. by Christopher R. Schlieve (3179439)

VEGF mutant duodenum displayed longer villi compared to littermates. by Christopher R. Schlieve (3179439)

sFlt-1 mutant duodenum displayed shorter villi, increased crypt depth and fewer crypts per length measured. by Christopher R. Schlieve (3179439)

Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development by Christopher R. Schlieve (3179439)

“…<div><p>Background</p><p>Vascular endothelial growth factor (VEGF) is a highly conserved, master regulatory molecule required for endothelial cell proliferation, organization, migration and branching morphogenesis. …”

Liability threshold model for nsCL/P. by Laurence J. Howe (5579186)

VEGF mutant villi demonstrated increased angiogenesis and vascular permeability. by Christopher R. Schlieve (3179439)