PowerPoint Slides for: 2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial by Thadhani R. (3363803)

Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design by Gergő Dargó (3138048)

“…The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on p<i>K</i>_a shifts using UV-pH titration. …”

Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design by Gergő Dargó (3138048)

“…The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on p<i>K</i>_a shifts using UV-pH titration. …”

data_sheet_1.docx by Wenting He (2547607)

“…We aimed to examine the proinflammatory and antibacterial effect of VB5 in macrophages infected with Mycobacterium tuberculosis (MTB) strain H37Rv and the therapeutic potential of VB5 in vivo with tuberculosis. …”

Significantly more biological pathways are altered in wild type mice than in <i>bid</i>-deficient mice following DEN treatment. by Changshun Yu (2794015)

“…Genes showing significantly altered expressions in DEN-treated wild type (WT) and <i>bid</i>-deficient (KO) liver were subjected to DAVID analysis coupled with KEGG Pathway analysis. …”

S1 Fig - by Marco Checa (2549590)

“…<p><b>A) Effect of CSE exposure on cell viability.</b> Cell viability was measured using trypan blue staining (0.4%, Invitrogen, T10282) in A549 after one week of exposure with 5% and 10% CSE. …”

E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy by Jennifer L. Major (3639472)

“…However, E2F6 induced a 40-fold increase of the <i>Bdh1</i> transcript and 890% increase in its protein levels in hearts from Tg pups implying a potential impact on ketolysis. …”

³¹P NMR spectroscopy indicates an energy deficit in 6-week-old <i>mdx</i> mice. by Christopher R. Heier (410734)

“…A) Representative ³¹P NMR spectra illustrating the peaks of several energy metabolites in one wild-type (left) and one <i>mdx</i> (right) mouse, from weeks 6 through 12. …”

BMP signaling is required between 27 and 37 hpf for <i>runx2b</i> expression and head cartilage development. by Julia Dalcq (116948)

“…Dorsomorphin treatment of wt embryos and heat shock treatment of <i>(hsp70l:dnBmpr-GFP)w30</i> between 27 hpf and 37 hpf decreases <i>runx2b</i> expression in pharyngeal cartilage, but not in the cleithrum. …”

Demographic and ocular features. by Mingxi Shao (10066570)

“…The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.</p><p>Conclusion</p><p>The decrease in TAS levels and the increase in H₂O₂ and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.…”

Machine learning model to diagnose PCG. by Mingxi Shao (10066570)

“…The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.</p><p>Conclusion</p><p>The decrease in TAS levels and the increase in H₂O₂ and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.…”

ROC curves of TAS + SOD + MDA to diagnose PCG. by Mingxi Shao (10066570)

“…The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.</p><p>Conclusion</p><p>The decrease in TAS levels and the increase in H₂O₂ and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.…”

A Porphodimethene Chemical Inhibitor of Uroporphyrinogen Decarboxylase by Kenneth W. Yip (257594)

“…Because there is no known chemical UROD inhibitor suitable for use in translational studies, we aimed to design, synthesize, and characterize such a compound. …”

Declining seroprevalence of hepatitis A in Vojvodina, Serbia by Snežana Medić (4911829)

“…<div><p>To assess the current hepatitis A virus (HAV) endemicity in the Autonomous Province of Vojvodina, Serbia, we examined the seroprevalence and susceptibility profiles of the general population. …”

Effect of double mutants of GG(D/E)EF or EAL domain proteins on invasion of <i>S. typhimurium</i> into HT-29 cells. by Irfan Ahmad (194014)

“…WT = wild type <i>S. typhimurium</i> UMR1. Bars show mean ± standard deviation from at least 5 independent biological experiments performed in two technical replicates. …”

Table_1_IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren’s Syndrome Patients.doc by Jing Luo (146659)

“…In vitro IL-2 treatment-induced STAT5 competed with STAT3 binding in human Il17a locus, leading to decreased Th17 differentiation, which was associated with the reduced transcription activation marker H3K4me3.…”

Table_1_The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro.docx by Roberta Dal Magro (5474120)

“…The results showed that discoidal HDL displayed a superior capability to promote Aβ efflux in vitro (9 × 10^-5 cm/min), when compared to apoA-I in other lipidation states. …”

CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with <i>Plasmodium berghei</i> by Ifeanyi U. Anidi (446498)

“…To define the role that the scavenger receptor CD36 may play in mediating this response, C57BL/6J (WT) and CD36−/− mice were infected with <i>P. berghei</i> ANKA and monitored for changes in pulmonary endothelial barrier function employing an isolated perfused lung system. …”

Western blot analysis of VP40 in NHP plasma with longitudinal collections. by Qingbo Shu (1555585)

“…Well 1–5 represent for a two-fold decrease of VP40 loading starting from 870 nanogram. …”

DataSheet1_One-dimensional modeling of heterogeneous catalytic chemical looping steam methane reforming in an adiabatic packed bed reactor.pdf by Haris Qayyum (17415264)

“…At the optimum temperature (950 K), pressure (1 bar), and steam-to-carbon molar ratio (3/1), with an increase in particle diameter from 0.7 to 1 mm, an 18% decrease in methane conversion and a 9.5% increase in hydrogen yield were observed. …”