3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations حسب Isra Marei (11312895)

"…Besides factors such as the increased cost of clinical trials and increases in the requirements and the complexity of the regulatory processes, there is also a gap between the currently existing pre-clinical screening methods and the clinical studies in humans. …"

Role of cytokines and platelet-activating factor in inflammatory bowel disease حسب Nassif, Anis

"…Cytokines are peptides that regulate and coordinate inflammatory and immunologic responses. Increased production of cytokines has been reported during Crohn's disease and ulcerative colitis and is correlated with disease activity. …"
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Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone حسب Abdoulaye Diane (14152749)

"…A similar increase in DNAJB3 mRNA was also observed in HepG2 cells. …"

Elucidating the Probiotic Potential of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A... حسب Sidra A Uzair (23124226)

"…The evidence indicates the potential of <i>Lactobacillus</i>- and <i>Bifidobacterium</i>-based probiotic interventions to beneficially influence glucose metabolism, inflammatory response, and gut microbial balance in GDM. Heterogeneity in probiotic formulations across studies, probiotic doses, and regional differences in diet and lifestyle underscore the need for more targeted and standardized research to fully understand the therapeutic potential of probiotics in GDM.…"

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…Using functional assays, we confirmed that atezolizumab increases MDA-MB-231 cell apoptosis/necrosis, and reduces their proliferation and viability. …"

Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis حسب Muneera Vakayil (12037693)

"…Therefore, understanding the cellular mechanisms responsible for adipogenesis, the conversion of preadipocytes to adipocytes, is critical for identifying anti-diabetic therapeutic targets. …"

Extramedullary haematopoiesis in patients with transfusion dependent β-thalassaemia (TDT): a systematic review حسب Eihab A. Subahi (12217761)

"…However, there are increasingly reported cases of EMH in BTM. The incidence of EMH in BTM is thought to be <1%. …"

Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter حسب Zalloua, P. A.

"…We have cloned a novel NF-κB-based reporter system (five tandem repeats of NF-κB responsive genomic element (NF; 14 bp each)) to drive the expression cassette for both a fusion between the yeast cytosine deaminase and uracil phosphoribosyltransferase (CU) as a therapeutic gene and the secreted Gaussia luciferase (Gluc) as a blood reporter, separated by an internal ribosomal entry site (NF-CU-IGluc). …"
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Arsenic: A double-edged sword حسب Nature Research (16552612)

"…Research shows that As₂O₃increases intracellular calcium ion concentration irreversibly. …"

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer حسب Adviti Naik (673163)

"…</p><h3>Conclusions</h3><p dir="ltr">Our findings suggest that targeting LDHC could enhance anti-tumor immune responses by modulating cytokine and chemokine secretion in addition to impairing immune checkpoint signaling. …"

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance حسب Gh Rasool Bhat (13038132)

"…This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. …"

DJ-1, a peten inhibitor, is a positive regulator of cancer cell motility. (c2014) حسب Yassine, Rawan M.

"…DJ-1 is a 20-KDa protein that was first identified as an oncogene product responsible for a subset of familial Parkinson’s disease; hence its name PARK 7. …"
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Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers حسب Olfa Khalifa (10914452)

"…<p>Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). It is increasingly becoming evident that NAFLD is a disease affecting numerous extrahepatic vital organs and regulatory pathways. …"

Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment حسب Mohammad A. I. Al-Hatamleh (11564929)

"…From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. …"

Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases حسب Nour K., Younis

"…A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. …"
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Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia حسب Hanan Ehtewish (17149825)

"…And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. …"

Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases حسب Nour K. Younis (14152512)

"…A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. …"

SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways حسب Yasser Majeed (9417974)

"…Supplementing preadipocytes with the NAD+ booster nicotinamide mononucleotide (NMN) during differentiation increased expression levels of leptin, SIRT1, and PGC-1α and its transcriptional targets, and reduced levels of pro-fibrotic collagens (Col6A1 and Col6A3) in a SIRT1-dependent manner. …"