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Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy
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iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion
Published 2022“…Therefore, in this study, we aimed to investigate the genetic perturbations associated with insulin resistance (IR) in the offspring of T2D parents using patient-specific iPSCs.…”
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Published 2024“…Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. …”
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Emerging therapies in multiple myeloma
Published 2015“…However, despite the increased effectiveness of the first-line agents, the majority of patients will eventually relapse and become drug resistant. …”
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Natural products as chemo-radiation therapy sensitizers in cancers
Published 2022“…Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for most advanced tumors. …”
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Prophylactic and therapeutic antibiotic patterns of lebanese dentists for the management of dentoalveolar abscesses
Published 2016“…The main prescribed antibiotic was amoxicillin.This study showed that dentists often did not follow the current prophylactic and therapeutic antibiotic prescription guidelines.Antibiotics prescriptions in dentistry will be more pertinent, leading to a decrease in inadequacy of prescriptions, microbial resistance, and the development of multiresistant germs against antibiotics…”
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Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway
Published 2018“…A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. …”
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The changing landscape in the treatment of metastatic castration-resistant prostate cancer
Published 2012“…The past few years have brought increasing advances in the therapeutic management of metastatic castration-resistant prostate cancer with the approval of several agents, including vaccine therapy with sipuleucel-T, second-line chemotherapy with cabazitaxel, the bone-targeted pharmaceutical denosumab, and the novel antiandrogen therapy abiraterone acetate. …”
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Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation
Published 2019“…Challenging lung airway epithelial cells (AECs) with LBCs decreased (by more than 50%) transepithelial resistance (TER) denoting barrier function alteration. …”
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Integrated transcriptional‐phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients
Published 2021“…<h3>Background</h3><p dir="ltr">The combination of immune checkpoint blockade (ICB) with standard therapies is becoming a common approach for overcoming resistance to cancer immunotherapy in most human malignancies including metastatic renal cell carcinoma (mRCC). …”
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Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting
Published 2020“…<h3>Background</h3><p dir="ltr">Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. …”
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
Published 2017“…Normal cells, on the other hand, were resistant to HuArgI (Co)-PEG5000-induced arginine deprivation. …”
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Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018)
Published 2018“…Glioblastoma multiforme (GBM) is a highly aggressive glioma arising in the central nervous system accounting for more than 70% of all brain tumors. Due to the resistance and complexity of the tumor itself, it is characterized by a low survival rate and decreased prognosis. …”
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Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells
Published 2021“…Western blot analysis showed significant decrease in stem cell markers SOX-2 and Oct-4, and tumorigenic protein HMGA1, whereas it showed significant increase in apoptotic markers cleaved PARP and cleaved caspase-3. …”
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Molecular characterization of extended-spectrum beta-lactamase producing escherichia coli. (c2014)
Published 2016“…These results agree with previously published studies in Lebanon and worldwide and highlight the increasing incidence and dissemination of these pathogens in the hospital and community setting and draws attention to the broadening of resistance among ESBLs whereby therapy alternatives are becoming scarce.…”
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