Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy by Taki, Fatima

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Editorial: Engineered immune cells in cancer immunotherapy (EICCI) by Francisco Martin (26407)

Immunoprofile of childhood diabetes by Meritxell Espino-Guarch (15430868)

“…Associated with these findings, anti-inflammatory Treg cytokines including IL-10 were decreased in T2D patients and elevated plasma levels of IL-17, which contributes to the insulin resistance and inflammation were observed.…”

Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies by Sabah Nisar (12561961)

The Human Microbiome in Chronic Kidney Disease: A Double-Edged Sword by Eman Wehedy (13275305)

DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation by Abdelilah Arredouani (10914455)

“…Using JNK1- and IKKβ-dependent luciferase reporters, we show a marked decrease in luciferase activity by DNAJB3 in response to PMA and TNF-α that was consistent with a decrease in the translocation of p65/NF-κB to the nucleus in response to LPS. …”

Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in... by Eleftheria Lefkou (17052414)

“…Wire myography was used to identify the mechanisms underpinning the protective effects of the triple therapy in the mouse model of OAPS.</p><h3>Results</h3><p dir="ltr">The triple therapy increased serum NO levels, diminished uteroplacental vessels resistance improving placental function and prolonged pregnancies compared to conventional treatment LMWH + LDA, leading to live births in women with OAPS. …”

Dissecting bloodstream infections in febrile neutropenic patients with hematological malignancies, a decade-long single center retrospective observational study (2009–2019) by Halima El Omri (14778790)

“…Conclusion Decision pertaining to the usage of antimicrobials for HM-FN-BSI patients is a critical task that relies on the latest pattern of prevalence, treatment resistance, and clinical outcomes. Analysis of the antibiogram of HM-FN-BSI patients in Qatar calls for a reconsideration of currently followed empirical antibiotic therapy towards better infection control and antimicrobial stewardship.…”

Beyond genetics: Exploring the role of epigenetic alterations in breast cancer by Kirti S. Prabhu (4246144)

“…Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing to less-than-ideal patient outcomes. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…This study was designed to confirm the human studies in a mouse model of dietary obesity-induced insulin resistance, and, if validated, to understand the underlying mechanisms. …”

Prediction of Multiple Clinical Complications in Cancer Patients to Ensure Hospital Preparedness and Improved Cancer Care by Regina Padmanabhan (14231606)

“…Myelosuppression due to treatment increases the risk of sepsis and mortality in hematological cancer patients with febrile neutropenia. …”

Dicarbonyl stress, protein glycation and the unfolded protein response by Naila Rabbani (291722)

“…<p>The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. …”

Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment by Matli, Kamal

“…Therefore, understanding the effect of antiplatelet and anticoagulation therapy in the context of COVID-19 treatment is important. …”
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Oxandrolone Treatment in Adults with Severe Thermal Injury by Btaiche, Imad F.

“…During the rehabilitation period, oxandrolone therapy with adequate nutrition and exercise improved lean body mass, increased muscle strength, and restored body weight. …”
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Reply to Comments by Kakkar and Dahiya by Chahine, Elias B.

“…Initial reports describing the use of bedaquiline in patients with MDR-TB and extensively drug-resistant TB are promising.3,4 Fortunately, the World Health Organization (WHO) has recently issued an interim policy guidance recommending that bedaquiline may be added to a WHO-recommended regimen in adult patients with MDR-TB when an effective regimen containing 4 second-line drugs in addition to pyrazinamide cannot be designed, and when there is documented evidence of resistance to any fluoroquinolone in addition to multidrug resistance.5 Similarly, the Centers for Disease Control and Prevention (CDC) has also issued provisional guidelines recommending that bedaquiline may be used for 24 weeks in adults with laboratory-confirmed pulmonary MDR-TB when an effective regimen cannot otherwise be provided; on a case-by-case basis in children, persons with HIV, pregnant women, persons with extrapulmonary MDR-TB, and patients with comorbidties when effective regimen cannot otherwise be provided; and on a case-by-case basis for durations longer than 24 weeks when an effective regimen cannot be provided.6 Both WHO and CDC emphasize the need for careful monitoring of patients on bedaquiline therapy for safety concerns.5,6 Until further data become available, the authors believe that patients who meet eligible criteria according to current guidelines may benefit from bedaquiline therapy with careful monitoring for potential side effects and drug interactions.…”
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FoxP3⁺ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets by Reem Saleh (3513056)

“…Despite the success of immunotherapy, including the use of immune checkpoint inhibitors, a significant proportion of patients show low response rates as a result of primary or acquired resistance against therapy. Some of the mechanisms which underlie the development of therapy resistance are associated with Treg suppressive function. …”

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors by Naila Rabbani (291722)

“…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …”

Altered Regulation of the Glucose Transporter GLUT3 in PRDX1 Null Cells Caused Hypersensitivity to Arsenite by Reem Ali (9913494)

“…In the absence of PRDX1, GLUT3 mRNA and protein expression levels are low, but they are increased upon arsenite treatment, correlating with an increased uptake of glucose. …”

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy by Ajaz A. Bhat (12984701)

“…We also discuss cytokine-chemokine oncogenic potential by contributing to the Epithelial-Mesenchymal Transition (EMT), angiogenesis, immunosuppression, metastatic niche, and therapeutic resistance development. In addition, it discusses the wide range of changes and intracellular signaling pathways that occur in the TME. …”

Emtricitabine/rilpivirine/tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults by Kabbara, Wissam K.

“…Rilpivirine showed cross resistance to efavirenz and etravirine. Efavirenz, on the other hand, did not demonstrate cross resistance to rilpivirine and etravirine, leaving the latter drugs as options for use in case of virological failure with efavirenz. …”
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