Showing 1 - 20 results of 451 for search '(( lead optimization decrease ) OR ( ct ((largest decrease) OR (marked decrease)) ))', query time: 0.63s Refine Results
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. 8
  9. 9
  10. 10

    The existence of GPs’ optimal solution. by Xuejing Cao (2447455)

    Published 2025
    “…Moreover, the introduction of telemedicine could lead to higher social welfare as it improves the accessibility of services to patients, especially in rural areas. …”
  11. 11
  12. 12
  13. 13
  14. 14
  15. 15

    Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models by Samantha M. Meyer (14070275)

    Published 2025
    “…Increasing linker length from two polyethylene glycol units to eight increased RiboTAC potency, while longer linker lengths decreased potency. The optimized RiboTAC reduced the abundance of oncogenic <i>LGALS1</i> transcripts in THP-1 leukemia cells (∼95%) and in MDA-MB-231 triple negative breast cancer cells (∼70%), leading to a subsequent decrease of galectin-1 protein and induction of apoptosis. …”
  16. 16

    Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models by Samantha M. Meyer (14070275)

    Published 2025
    “…Increasing linker length from two polyethylene glycol units to eight increased RiboTAC potency, while longer linker lengths decreased potency. The optimized RiboTAC reduced the abundance of oncogenic <i>LGALS1</i> transcripts in THP-1 leukemia cells (∼95%) and in MDA-MB-231 triple negative breast cancer cells (∼70%), leading to a subsequent decrease of galectin-1 protein and induction of apoptosis. …”
  17. 17

    Fluorine-Induced Anomalous Optical Stability and Pressure-Enhanced Emission Property of 0D Lead Perovskite Derivatives by Congcong Chen (796149)

    Published 2025
    “…Here, we report two highly luminescent 0D lead bromides, (BPP)<sub>2</sub>PbBr<sub>4</sub> and (BPPF)<sub>2</sub>PbBr<sub>4</sub>·2H<sub>2</sub>O, abbreviated as BPP-0D and BPPF-0D (BPP = benzyltriphenylphosphonium, BPPF = (4-fluorobenzyl)triphenylphosphonium). …”
  18. 18

    Fluorine-Induced Anomalous Optical Stability and Pressure-Enhanced Emission Property of 0D Lead Perovskite Derivatives by Congcong Chen (796149)

    Published 2025
    “…Here, we report two highly luminescent 0D lead bromides, (BPP)<sub>2</sub>PbBr<sub>4</sub> and (BPPF)<sub>2</sub>PbBr<sub>4</sub>·2H<sub>2</sub>O, abbreviated as BPP-0D and BPPF-0D (BPP = benzyltriphenylphosphonium, BPPF = (4-fluorobenzyl)triphenylphosphonium). …”
  19. 19
  20. 20