Search alternatives:
largest decrease » larger decrease (Expand Search)
marked decrease » marked increase (Expand Search)
step decrease » sizes decrease (Expand Search), teer decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
largest decrease » larger decrease (Expand Search)
marked decrease » marked increase (Expand Search)
step decrease » sizes decrease (Expand Search), teer decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
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<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b>
Published 2025“…The majority of functional beta cell mass is typically lost within months to years of disease diagnosis, but the timing and nature of this loss, particularly in early disease stages, remain unclear. We developed a whole-slide scanned image (WSI) analysis pipeline for semi-automated quantitation of endocrine areas, islet frequencies, inter-islet distances, and endocrine object size distribution in 145 human pancreata from 60 non-diabetic (ND), 19 single autoantibody positive (sAAb+), 10 multiple autoantibody positive (mAAb+), 16 recent-onset (0-1 year duration), 23 medium-duration (1-7 years), and 17 long-duration type 1 diabetes (7+ years) donors. …”
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S1 File -
Published 2025“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”
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Knockdown of ATP2C1 results in a minor decrease of [Ca<sup>2+</sup>] in WPB.
Published 2025Subjects: -
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