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    Development of Potent and Selective Dual PPARδ/sEH Modulators from an AI-Designed Scaffold by Xiu Ge (13802019)

    Published 2025
    “…Systematic SAR exploration of the scaffold identified substructures driving PPARδ agonism or sEH inhibition and a combination of favored modifications provided potent dual modulators. The optimized dual ligands displayed balanced activity on both proteins of interest and selectivity over related targets including the PPARα/γ subtypes. …”
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