GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”

Quantification of blood ACE levels in carriers of ACE mutations. by Olga V. Kryukova (19819428)

Differential gene sets associated with the transcriptional host response to SARS-CoV-2 infection across serially collected samples. by Vasanthi Avadhanula (259546)

Actuating neuronal activity of Ssdp-expressing neurons alters autism-associated behaviors. by Safa Salim (9186786)

“…(E) Habituation speed is significantly increased in Ssdp^[2082-G4] flies (<i>n</i> = 44, Cliff’s Δ = 0.60 [95 CI 0.376, 0.756], <i>p</i> < 0.0001); however, it is significantly decreased in Ssdp^[2082-G4]>UAS-Chrimson (<i>n</i> = 42–43, Cliff’s Δ = −0.26 [95 CI −0.487, −0.00886], <i>p</i> = 0.041) and Ssdp^[2082-G4] >UAS-GtACR1flies (<i>n</i> = 30–31, Cliff’s Δ = −0.31 [95 CI −0.563, −0.0043], <i>p</i> = 0.035) compared to their controls. …”

<i>Ssdp</i> knockdown in Ssdp-Gal4 labeled cells partially rescues autism-associated behaviors. by Safa Salim (9186786)

“…(C) Heterozygous Ssdp^[2082-G4] /+ flies show a significantly higher wall-following compared to controls (<i>n</i> = 49–57, Cliff’s Δ = 0.47 [95 CI 0.256, 0.651], <i>p</i> < 0.0001); however, Ssdp^[2082-G4]>UAS-Ssdp-RNAi flies show wall-following behavior similar to controls (<i>n</i> = 57–61, Cliff’s Δ = −0.031 [95 CI −0.246, 0.183], <i>p</i> = 0.78) and significantly decreased wall-following compared to Ssdp^[2082]/+ flies (<i>n</i> = 49–61, Cliff’s Δ = −0.62 [95 CI −0.768, −0.428], <i>p</i> < 0.0001). …”

Biochemical characterization of the endolysins of the lactococcal phages P008, c2, 1358, and P335. by Frank Oechslin (4825476)

“…<p>(<b>A)</b> The endolysin of phage P008 (LysP008) is composed of an amidase_2 CD that is known to hydrolyse the glycan–peptide linkage and a C-terminal region with homology to the CBD of the endolysin found in the <i>Enterococcus</i> phage IMEEF1 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001740#pbio.3001740.ref026" target="_blank">26</a>]. …”

Supplementary Material for: Effects of Low-Volume, High-Intensity Interval Training Compared with Continuous Training on Regional and Global Body Composition in Adults with Metabol... by Aristizabal J.C. (11527624)

Multiple homologs of 16p12.1 genes contribute to neurodevelopmental defects in <i>Drosophila melanogaster</i> and <i>X</i>. <i>laevis</i>. by Lucilla Pizzo (2735491)

“…Knockdown of <i>cdr2</i> (n = 54, two-tailed student’s t-test, *p = 7.75 ×10⁻⁴), <i>polr3e</i> (n = 37, *p = 1.97 ×10⁻¹³) and <i>mosmo</i> (n = 50, *p = 1.36 ×10⁻¹¹) led to decreased face width, while knockdown of <i>polr3e</i> (*p = 3.29 ×10⁻¹⁶) and <i>mosmo</i> (*p = 1.47 ×10⁻⁸) led to decreased orofacial area. …”

Table1_Changes in carotid artery texture by ultrasound and elastin features in a murine model.xlsx by Carol Mitchell (3525455)

Image 1_Ticagrelor vs. clopidogrel in dual antiplatelet therapy after coronary artery bypass surgery: a meta-analysis.tif by Liyuan Wang (795570)

“…</p>Results<p>4 randomized controlled trials and 3 observational studies (n = 2,424) were eligible for final analysis. A + T was associated with a decreased risk of all-cause mortality (OR = 0.47, 95% CI 0.31–0.70, p < 0.001, p heterogeneity = 0.80, I² = 0%) and cardiovascular mortality (OR = 0.50, 95% CI 0.31–0.82, p = 0.006, p heterogeneity = 0.71, I² = 0%), compared with A + C group. …”

Image 2_Ticagrelor vs. clopidogrel in dual antiplatelet therapy after coronary artery bypass surgery: a meta-analysis.tif by Liyuan Wang (795570)

“…</p>Results<p>4 randomized controlled trials and 3 observational studies (n = 2,424) were eligible for final analysis. A + T was associated with a decreased risk of all-cause mortality (OR = 0.47, 95% CI 0.31–0.70, p < 0.001, p heterogeneity = 0.80, I² = 0%) and cardiovascular mortality (OR = 0.50, 95% CI 0.31–0.82, p = 0.006, p heterogeneity = 0.71, I² = 0%), compared with A + C group. …”

Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analy... by L. Telisinghe (18706323)

Activation of deep SC neurons recapitulates delayed LER in <i>Setd5</i>^<i>+/−</i> animals. by Laura E. Burnett (18794525)

“…(<b>l</b>) Proportion of trials at different contrast looms that show an increase (white), decrease (black), or no change (grey) in speed upon light activation (20%: <i>p</i> = 0.698; 50%, <i>p</i> = 0.026; 98%, <i>p</i> = 0.021, X² test of independence). …”

Evaluation of ocular surface in children with attention deficit hyperactivity disorder with respect to methylphenidate treatment by Emre Aydemir (13106446)

“…However, Group B showed a significant decrease in tear film break-up time (10.50 ± 3.39 vs. 12.52 ± 2.46 s; p=0.005), tear meniscus height (307.40 ± 5.53 vs. 310.82 ± 7.30 µm; p=0.025), tear meniscus area (0.024 ± 0.0037 vs. 0.026 ± 0.0046 mm2; p=0.010) and Schirmer test (12.75 ± 3.96 vs. 15.41 ± 3.75 mm; p=0.004) results compared with Group A. …”

Dfos increases Rho1-GTP, the formin Diaphanous and actin at the cortex through Cher and TM4SF. by Vera Belyaeva (11914218)

“…Scale bar 10 μm in <b>(B-C, F-H)</b>, 50 μm in (<b>I, K</b>). The data underlying the graphs can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001494#pbio.3001494.s004" target="_blank">S1 Data</a>. …”

Supplementary Material for: Identification of risk factors associated with metabolic dysfunction-associated steatotic liver disease in psoriatic patients by Küçük K. (20178678)

“…We identified parameters which were more prevalent in patients with psoriasis having MASLD, specifically a high BMI, elevated triglycerides levels, decreased HDL levels and an elevate level of C-peptide. …”