Showing 1 - 9 results of 9 for search '(( primary data dose optimization algorithm ) OR ( binary data joint optimization algorithm ))', query time: 0.67s Refine Results
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    Supplementary Material for: Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes by Yu Y. (3096192)

    Published 2022
    “…Introduction: Increasingly, logistic regression methods for genetic association studies of binary phenotypes must be able to accommodate data sparsity, which arises from unbalanced case-control ratios and/or rare genetic variants. …”
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    DataSheet_2_Optimising Treatment Outcomes for Children and Adults Through Rapid Genome Sequencing of Sepsis Pathogens. A Study Protocol for a Prospective, Multi-Centre Trial (DIREC... by Adam D. Irwin (11011752)

    Published 2021
    “…We set out to demonstrate the feasibility and diagnostic accuracy of pathogen sequencing direct from clinical samples, and estimate the impact of this approach on time to effective therapy when integrated with personalised software-guided antimicrobial dosing in children and adults on ICU with sepsis.</p>Methods<p>The DIRECT study is a pilot prospective, non-randomized multicentre trial of an integrated diagnostic and therapeutic algorithm combining rapid direct pathogen sequencing and software-guided, personalised antibiotic dosing in children and adults with sepsis on ICU.…”
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    DataSheet_1_Optimising Treatment Outcomes for Children and Adults Through Rapid Genome Sequencing of Sepsis Pathogens. A Study Protocol for a Prospective, Multi-Centre Trial (DIREC... by Adam D. Irwin (11011752)

    Published 2021
    “…We set out to demonstrate the feasibility and diagnostic accuracy of pathogen sequencing direct from clinical samples, and estimate the impact of this approach on time to effective therapy when integrated with personalised software-guided antimicrobial dosing in children and adults on ICU with sepsis.</p>Methods<p>The DIRECT study is a pilot prospective, non-randomized multicentre trial of an integrated diagnostic and therapeutic algorithm combining rapid direct pathogen sequencing and software-guided, personalised antibiotic dosing in children and adults with sepsis on ICU.…”
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    Variable Selection with Multiply-Imputed Datasets: Choosing Between Stacked and Grouped Methods by Jiacong Du (12035845)

    Published 2022
    “…Building on existing work, we (i) derive and implement efficient cyclic coordinate descent and majorization-minimization optimization algorithms for continuous and binary outcome data, (ii) incorporate adaptive shrinkage penalties, (iii) compare these methods through simulation, and (iv) develop an R package <i>miselect</i>. …”
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    Supplementary Material for: The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) Study: Trial Design and Baseline Characteristics by Wong M.G. (11640685)

    Published 2021
    “…By the time the excess of serious infections was observed, 262 participants had been randomized to the original full-dose treatment algorithm, and an interim analysis was reported in 2016. …”
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    Machine Learning-Ready Dataset for Cytotoxicity Prediction of Metal Oxide Nanoparticles by Soham Savarkar (21811825)

    Published 2025
    “…</p><p dir="ltr"><b>Applications and Model Compatibility:</b></p><p dir="ltr">The dataset is optimized for use in supervised learning workflows and has been tested with algorithms such as:</p><p dir="ltr">Gradient Boosting Machines (GBM),</p><p dir="ltr">Support Vector Machines (SVM-RBF),</p><p dir="ltr">Random Forests, and</p><p dir="ltr">Principal Component Analysis (PCA) for feature reduction.…”