Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas... حسب Basala, Sobhiya

"…MDA-MB-231 had the most significant uPAR expression, MCF-7 had a moderate level of expression, and UACC-2087 had negligible expression. …"
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Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment حسب Seán Fitzgerald (721911)

"…<h3>Background</h3><p dir="ltr">Stromal gene expression patterns predict patient outcomes in colorectal cancer. …"

The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells حسب Maram Hasan (6672440)

"…We noted that only the mRNA expression of Nrf2 was increased in cells treated with MSCs-CM (50%). …"

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice حسب Julie Decock (44558)

"…Throughout the 14 weeks of the model, tumor burden increased in homozygous Mmp8-null mice compared to Mmp8-wild-type and -heterozygote animals. …"

Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep حسب Abouantoun, Tamara

"…At 130 days of gestation, dexamethasone administered between 26 to 28 days of gestation (group DF; n8), resulted in an increased expression of angiotensinogen in hypothalamus (in arbitrary units: 2.5 0.3 versus 1.3 0.3 in the saline group [group SF], n10; P0.05). …"
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Editorial: Cancer testis antigens in cancer: Recent developments as cancer biomarkers and therapeutic targets حسب Adviti Naik (673163)

"…<p dir="ltr">Cancer testis antigens (CTAs) form a large family of proteins with highly restricted expression that is limited to male germ cells in the testis and trophoblast cells in the placenta. …"

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes حسب Radhakrishnan Vishnubalaji (3563306)

"…<p dir="ltr">Breast cancer (BC) is a heterogeneous disease, which is primarily classified according to hormone receptors and HER2 expression. Despite the many advances in BC diagnosis and management, the identification of novel actionable therapeutic targets expressed by cancerous cells has always been a daunting task due to the large heterogeneity of the disease and the presence of non-cancerous cells (i.e., immune cells and stromal cells) within the tumor microenvironment. …"

Indirect measurement of aneurysm wall thickness using digital stethoscope حسب Jou, Liang-Der

"…Aneurysms at 6 mm produced very low frequency sound. Wall thickness decreases with aneurysm size, and the decrease is more pronounced at 8 mm. …"
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Formation of Trihalomethanes during Seawater Chlorination حسب Ahmed Abdel-Wahab (1748986)

"…Rapid decrease of UV absorbance at 254 nm was also observed during seawater chlorination which is indicative of natural organic matter degradation into small organic molecules including THMs and other by-products. …"

Simulation Study of Thermal Effects of Vegetation Covered Sand dune mounds within the Landscape around Urban Structures in the UAE حسب Al-Yaqoob, Dana

"…Dubai is just one of many cities that have had a rapid growth in development, leading to the condition of urban heat island. …"
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Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro حسب Khalife, Rana

"…Both drugs induced apoptosis through a p53-independent mechanism, whereas the expression of p21 was only seen in thymoquinone treatment. …"
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Lead Nitrate Induces Inflammation and Apoptosis in Rat Lungs Through the Activation of NF-κB and AhR Signaling Pathways حسب Ibraheem M. Attafi (14151735)

"…Importantly, the Pb-induced lung inflammation and apoptosis were associated with a proportional increase in the expression of NF-κB and AhR mRNAs and proteins. …"

Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model حسب Kobeissy, Firas

"…Molecular analysis revealed that nephrin expression was significantly reduced in the S+MI group, whereas sodium-hydrogen exchanger-1 (NHE-1) was significantly increased, suggesting altered glomerular filtration and kidney functions. …"
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Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line حسب Toutounji, Mohamad

"…This was associated with an alteration in the expression levels of inflammatory factors in addition to an increase in the expression of the ER stress protein markers, namely immunoglobulin-binding protein (BiP), C/EBP homologous protein (CHOP), activation transcription factor 4 (ATF4), and X-box binding protein (XBP1). …"
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mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation حسب Georgess, Dan

"…In mice with mTORC1 loss of function, we found that Rho kinase (ROCK) signaling was constitutively activated, resulting in increased cytoskeletal tension and impaired cell-cell adhesion. …"
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The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase حسب Kthiri, Fatoum

"…YbbN specifically interacts with DnaK and GroEL, as shown by reverse purification. It increases 4-fold the rate of protein renaturation in vitro by the DnaK chaperone machine, suggesting that it cooperates with DnaK for the optimal expression of several cytoplasmic proteins.…"
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TRPV2: A Cancer Biomarker and Potential Therapeutic Target حسب Kodappully S. Siveen (4246150)

"…Another link was found between TRPV2 expression and either drug-induced cytotoxicity or stemness of liver cancer. …"

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells حسب Khoury, Oula

"…Knocking-down ASS1 reversed the ability of l-citrulline to rescue GBM cells, further illustrating the dependence of arginine auxotrophy on ASS1 expression. Inhibition of autophagy increased cell sensitivity to HuArgI (Co)-PEG5000 indicating that, following arginine deprivation, autophagy plays a protective role in GBM cells. …"
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Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro حسب Rizk, Sandra

"…With respect to the proteins studied, treatment with Urtica dioica extract significantly increased the expression of the pro-apoptotic protein Bax with concomitant decrease in the anti-apoptotic protein Bcl-2 expression. …"
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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 حسب Harshita Shailesh (14779408)

"…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …"