Table 6_CX3CR1 upregulation modulates microglial activation and preserves synapses in the hippocampus and frontal cortex of middle-aged mice.xlsx حسب Jinfeng Liu (32678)

"…Introduction<p>The aging brain shows alterations in microglial function, morphology, and phenotype, reflecting a state of chronic activation. CX3CR1 plays a critical role in regulating microglial chemotaxis, phagocytosis, and activation. …"

Data Sheet 1_HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1.pdf حسب Keita Tanigaki (13162449)

"…In HAX1-knockdown IHGE cells, significantly decreased levels of JAM1 were found. Additionally, cisplatin, a chemotherapeutic agent reported to inhibit HAX1, also led to decreased expression of both HAX1 and JAM1. …"

Deletion of glycosyltransferase <i>galE</i> impairs the InlB anchoring and pathogenicity of <i>Listeria monocytogenes</i> حسب Xiaowei Fang (696967)

"…In this study, we deleted the <i>galE</i> gene, which is involved in galactosylation, from <i>L. monocytogenes</i> strain ScottA. We found that <i>galE</i> deletion reduced InlB anchoring, weakened bacterial adhesion and invasion of Caco-2 cells (human colorectal adenocarcinoma cells) and MGC803 cells (human gastric carcinoma cells), increased phagocytosis but decreased proliferation in RAW264.7 cells (mouse mononuclear macrophage leukaemia cells), and decreased bacteria load, mortality, and tissue damage in infected mice. …"

Data Sheet 1_Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11.docx حسب Ling Li (38566)

"…Introduction<p>Bryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and cancer therapies. …"

DATA ALL PARTICIPANTS.xlsx حسب Angela Van Sickle (20441450)

"…For the 5 mL task, time to complete and area under the curve decreased as age increased. Across all ages, males required less time to consume and exhibited significantly less area under the curve when compared to females.…"

Supplementary file 1_Longitudinal assessment of oral and gut microbiome overlap in patients with Alcohol Use Disorder undergoing inpatient treatment.docx حسب Jennifer J. Barb (9153014)

"…Results indicated that the oral and gut microbiomes became less similar during the first week of treatment, with both the number of shared genera and Sorenson-Dice Index values decreasing significantly (p <.001). However, the Robust Aitchison Distance also decreased over time (p <.05), suggesting increased compositional similarity among the shared genera. …"

Table 2_Longitudinal assessment of oral and gut microbiome overlap in patients with Alcohol Use Disorder undergoing inpatient treatment.csv حسب Jennifer J. Barb (9153014)

"…Results indicated that the oral and gut microbiomes became less similar during the first week of treatment, with both the number of shared genera and Sorenson-Dice Index values decreasing significantly (p <.001). However, the Robust Aitchison Distance also decreased over time (p <.05), suggesting increased compositional similarity among the shared genera. …"

Data Sheet 1_Huoxue-Jiangtang decoction ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced rats.pdf حسب Maosheng Lee (13041531)

"…Moreover, the levels of glycogen synthetase (GS), hexokinase, superoxide dismutase (SOD), glycogen, and muscle glycogen in the HXJT group significantly increased relative to those in untreated T2DM group, while TNF-α levels decreased observably. …"

Table 1_Comparative analysis of soil properties before and after Morchella sextelata cultivation across various soil types.xlsx حسب Juan Zhao (109151)

"…In this study, our results reveals that cultivation significantly alters soil properties and microbial communities in a soil type-dependent manner. …"

Table 1_The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023.doc حسب Xiaohui Ji (711427)

"…Long duration outdoors work (≥4 h) decreased from 36.01, 30.93 to 24.53% (Z = −9.80, p < 0.01) and bicycling/walking decreased from 62.3, 27.9, to 9.7% (CMH value = 156.40, p < 0.01) significantly during the last three decades. …"

Data Sheet 1_Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway.pdf حسب Zulipikaer Wusiman (20852138)

"…In addition, transcriptome analysis indicated that GA likely acts through the mitogen-activated protein kinase (MAPK) signaling pathway. GA has a strong binding affinity for important targets.GA significantly increased the expression of genes such as mapk8b, mapk14a, mapk3, mitf, tyr, tyrp1b, tyrp1a, dct, and oca2, and decreased the expression of genes such as expression of genes such as raf1 and egfr. …"

DataSheet1_Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach.docx حسب Wen-Di Wang (20400446)

"…Further research revealed that Z-LIG/CGA treatment significantly increased IL-1R2 levels, significantly decreased IL-17RA levels, and inhibited the activation of p-STAT1, thereby alleviating cell apoptosis after MI. …"

Table 2_Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine... حسب Qi Sun (127)

"…Furthermore, IP ameliorated the cartilage extracellular matrix degradation, significantly increased Aggrecan and Col II expression and decreased the expression of MMP13 and ADAMTS-4. …"

Table 1_Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine... حسب Qi Sun (127)

"…Furthermore, IP ameliorated the cartilage extracellular matrix degradation, significantly increased Aggrecan and Col II expression and decreased the expression of MMP13 and ADAMTS-4. …"

Changes to the host transcriptome during infection. حسب Stefan Bresson (20623940)

"…The heatmap shows the most significantly decreased transcripts (by <i>p</i>-value). …"

Image 2_Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone.jpeg حسب Zetong Zheng (22069658)

"…LH, but not E2, significantly induced AQP2 expression in LGCs in a dose-dependent manner. …"

Data Sheet 1_Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway.docx حسب Tianyao Li (7388201)

"…It also decreased Aβ deposition and ameliorated neuronal apoptosis in the cerebral cortex. …"

Image 1_Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone.tif حسب Zetong Zheng (22069658)

"…LH, but not E2, significantly induced AQP2 expression in LGCs in a dose-dependent manner. …"

Table 1_Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone.docx حسب Zetong Zheng (22069658)

"…LH, but not E2, significantly induced AQP2 expression in LGCs in a dose-dependent manner. …"

The efficacy of metformin in counteracting olanzapine-induced hyperprolactinemia: an open-label prospective study حسب Kah Kheng Goh (4983368)

"…</p> <p>After eight weeks of metformin intervention, prolactin levels significantly decreased from 39.7 ± 20.0 ng/mL at baseline to 35.7 ± 15.7 ng/mL (<i>p</i> = 0.005) with a moderate effect size (Cohen’s <i>d</i> = 0.545). …"