Image 2_Human beta defensin-2 protects the epithelial barrier during methicillin-resistant Staphylococcus aureus infection in chronic rhinosinusitis with nasal polyps.tif by Tengfei Tian (1793545)

“…The presence of hBD-2 significantly reduced the invasive ability of MRSA in HNECs. …”

S1 File - by Shi-jie Wang (18569781)

“…The results showed that muscle TOR knockdown and endurance exercise significantly increased the climbing speed, climbing endurance, the expression of autophagy related gene 2(ATG2), silent information regulator 2(SIR2), and pparγ coactivator 1(PGC-1α) genes, and superoxide dismutases(SOD) activity, but it decreased the expression of the TOR gene and reactive oxygen species(ROS) level, and it protected the myofibrillar fibers and mitochondria of skeletal muscle in Drosophila on a high-salt diet. …”

YOLOv8n structure diagram. by Yaojun Zhang (389482)

“…Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…</p>Results<p>Alirocumab significantly improved spatial working memory, restored hippocampal long-term potentiation, and normalized synaptophysin expression. …”

Supplementary file 1_The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice.docx by You Yu (2102071)

“…Furthermore, the decreased levels of IPA in brain contributed to the attenuated aryl hydrocarbon receptor (AhR) signaling characterized by increased expression of downstream elements, including glutamate transporters and GABA receptors. …”

DataSheet_1_RETRACTED: Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 following ventilator associated pneumonia.docx by Youfeng Zhu (2460811)

“…Depletion of macrophages protected against lung epithelial cells and significantly decreased MMP9, MMP19, FTH, and FTL expression levels and increased GPX4 expression levels, while partially reversing the changes in macrophage. …”

Geometric model of the binocular system. by Yaojun Zhang (389482)

“…Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …”

Enhanced dataset sample images. by Yaojun Zhang (389482)

“…Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …”

Table 1_Evaluation of degree centrality and neurological outcomes in patients with herpes simplex encephalitis.docx by Dongzhi Liu (2747134)

“…In the HSE group, DC values were increased in the right thalamus, the left lingual gyrus, and the right hippocampus, while they were decreased in the left insula (all p < 0.001). …”

Data Sheet 1_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx by Alexia Giovanazzi (16816139)

“…At 12 months, the median change in HbA1c levels did not differ significantly between groups. Regarding app usage, data entries decreased significantly from the first quarter to the second quarter but subsequently stabilised (p = 0.001). …”

Table 2_Quercetin exhibits multi-target anti-allergic effects in animal models: a systematic review and meta-analysis of preclinical studies.docx by Zeyi Lv (19344178)

“…</p>Results<p>The meta-analysis showed that quercetin significantly decreased the expression of total IgE, OVA-specific IgE, and histamine, and suppressed the infiltration of eosinophils, macrophages, and lymphocytes. …”

Supplementary file 1_Assessing pteropod shell dissolution to advance ocean monitoring techniques: a methods comparison of SEM, CT, and light microscopy.zip by Bryce E. Koester (21473132)

“…<p>Pteropods are marine planktonic snails that are used as bioindicators of ocean acidification due to their thin, aragonitic shells, and ubiquity throughout the world’s oceans; their responses include decreased size, reduced shell thickness, and increased shell dissolution. …”

Data Sheet 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…Furthermore, the critical molecules PADI4, HMGB1, TLR4, and MYD88 were significantly upregulated in peripheral blood neutrophils from LN patients, and their expression levels in the kidneys of MRL/lpr mice increased in a time-dependent manner.…”

Image 4_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.tif by Si-Ting Huang (5591432)

“…In Nlrp3^-/- mice, IL-18 expression was downregulated, whereas markers of type 2 immunity, such as IL-4 and thymic stromal lymphopoietin (TSLP), were significantly upregulated in the skin. Furthermore, TRPA1 and its colocalization with the IL-4 receptor were increased in the DRG. …”

Table 5_Quercetin exhibits multi-target anti-allergic effects in animal models: a systematic review and meta-analysis of preclinical studies.docx by Zeyi Lv (19344178)

“…</p>Results<p>The meta-analysis showed that quercetin significantly decreased the expression of total IgE, OVA-specific IgE, and histamine, and suppressed the infiltration of eosinophils, macrophages, and lymphocytes. …”

Table 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…Furthermore, the critical molecules PADI4, HMGB1, TLR4, and MYD88 were significantly upregulated in peripheral blood neutrophils from LN patients, and their expression levels in the kidneys of MRL/lpr mice increased in a time-dependent manner.…”

Table 1_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.docx by Si-Ting Huang (5591432)

“…In Nlrp3^-/- mice, IL-18 expression was downregulated, whereas markers of type 2 immunity, such as IL-4 and thymic stromal lymphopoietin (TSLP), were significantly upregulated in the skin. Furthermore, TRPA1 and its colocalization with the IL-4 receptor were increased in the DRG. …”

Data Sheet 2_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx by Alexia Giovanazzi (16816139)

“…At 12 months, the median change in HbA1c levels did not differ significantly between groups. Regarding app usage, data entries decreased significantly from the first quarter to the second quarter but subsequently stabilised (p = 0.001). …”

Table 12_Quercetin exhibits multi-target anti-allergic effects in animal models: a systematic review and meta-analysis of preclinical studies.docx by Zeyi Lv (19344178)

“…</p>Results<p>The meta-analysis showed that quercetin significantly decreased the expression of total IgE, OVA-specific IgE, and histamine, and suppressed the infiltration of eosinophils, macrophages, and lymphocytes. …”

Supplementary file 1_Bibliometrics-guided cyberpharmacology and transcriptomics for multidimensional analysis of the antihepatic fibrosis mechanism of kaempferol.docx by Jiali Liu (327739)

“…Introduction<p>Hepatic Fibrosis (HF), a pathological remodeling process triggered by persistent liver damage, is marked by the excessive buildup of extracellular matrix (ECM), leading to a gradual deterioration of liver function and an increased likelihood of advancing to cirrhosis and liver failure.…”