Supplementary Material for: Preoperative prediction of microvascular invasion in intrahepatic cholangiocarcinoma and its prognostic implications: A multicenter study by figshare admin karger (2628495)

“…Stratifying patients by MVI risk—low (no predictors), intermediate (1–3 predictors), and high (4 predictors)— revealed a significant decrease in both recurrence-free and overall survival rates (p<0.001), along with a corresponding increase in early recurrence rates (p<0.001) as the risk level increased. …”

Datasheet3_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Datasheet3_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Datasheet2_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Datasheet1_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Table3_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies.x... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Table3_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies.x... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Datasheet2_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Datasheet1_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…</p>Conclusions<p>PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. …”

Image 1_Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population.pdf by Zhanyi Yang (5142182)

“…Furthermore, MORC4 knockdown led to an increased expression of genes associated with cholesterol synthesis (HMGCR), varying levels of genes implicated in the uptake of fatty acids and cholesterol (PCSK9, PLTP, CD36), and a decrease in the levels of genes involved in triglyceride hydrolysis (APOC2, APOA4, LIPG, LIPA). …”

Table 1_Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population.xlsx by Zhanyi Yang (5142182)

“…Furthermore, MORC4 knockdown led to an increased expression of genes associated with cholesterol synthesis (HMGCR), varying levels of genes implicated in the uptake of fatty acids and cholesterol (PCSK9, PLTP, CD36), and a decrease in the levels of genes involved in triglyceride hydrolysis (APOC2, APOA4, LIPG, LIPA). …”

Table 1_Dual roles of methoprene-tolerant gene TaMet in male molting and female reproduction of the tomato leafminer, Tuta absoluta (meyrick).docx by Tingwei Zhang (5992331)

“…Moreover, the expression levels of wing development and chitin metabolism genes decreased significantly after knocking down TaMet. …”

Data Sheet 1_Global, regional and national burden of neck pain in children and adolescents: GBD 2021 systematic analysis.pdf by Chao Sun (139686)

“…The global incidence of NP among children and adolescents increased from 3.17 million cases in 1990 to 3.82 million in 2021, while the age-standardized incidence rate showed a minimal decrease (AAPC −0.02%). …”

Data Sheet 1_Global trends and future predictions of gastrointestinal ulcers in youth.pdf by Kun He (178646)

“…</p>Conclusion<p>In 2019, the global burden of gastrointestinal ulcers showed significant increases in prevalent and incident cases, DALYs, and deaths compared to 1990. …”

<b>Triptolide alleviates </b><b>cognitive</b><b> impairment via </b><b>autophagy</b><b> and Akt/mTOR/p70S6K pathway in an APP/PS1 Alzheimer’s disease mouse model</b> by xinyao Qi (21686459)

“…Notably, TP treatment led to a reduction in hippocampal Aβ1-40 level, suggesting a decrease in Aβ neuropathology. …”

Lepidine potentiates the antidiabetic effect of metformin in nicotinamide/streptozotocin-induced diabetic male rats by Ayman S. Soliman (20718514)

“…Both lepidine and metformin treated diabetic rats showed a significant decrease in fasting blood glucose (FBG), amelioration of serum lipid profile, increase in serum insulin, and C-peptide , and downregulation in the elevated serum tumour necrosis α (TNF-α) level in association with the improvement in the pancreatic islet integrity and function. …”

Data Sheet 1_The impact of social activity on cardiovascular disease risk among middle-aged and older adults in China: a nationwide cohort study based on the CHARLS database.pdf by Yingting Wu (12215218)

“…After adjusting for age, gender, residence, education, marital status, smoking and drinking habits, chronic disease burden, depression, and BMI, each 0.1 decrease in social activity level was associated with a 7.4% increased risk of cardiovascular events (aHR, 1.074; 95% CI: 1.069–1.079).…”

Low-frequency dependence of HC context and EC object representations. by Pengcheng Lv (7609706)

“…While there was no significant decrease of HC context representation after excluding 8–30 Hz or 30–150 Hz activity. …”

Presentation 4_Pediatric healthcare service utilization after the end of COVID-19 state of emergency in Northern Italy: a 6-year quasi-experimental study using interrupted time-ser... by Matteo Puntoni (4901191)

“…Notably, hospitalization rates in adolescent girls (12–17 years) increased almost 4-fold (level change, HRR 3.72, 95%CI 2.02–6.85, p < 0.001), whereas the increase was not significant for boys in the same age group (level change, HRR 1.42, 95%CI 0.65–3.11, p = 0.378). …”

Presentation 1_Pediatric healthcare service utilization after the end of COVID-19 state of emergency in Northern Italy: a 6-year quasi-experimental study using interrupted time-ser... by Matteo Puntoni (4901191)

“…Notably, hospitalization rates in adolescent girls (12–17 years) increased almost 4-fold (level change, HRR 3.72, 95%CI 2.02–6.85, p < 0.001), whereas the increase was not significant for boys in the same age group (level change, HRR 1.42, 95%CI 0.65–3.11, p = 0.378). …”