Comparison between juvenile and adult demyelination. by Sara Hijazi (21656615)

“…<p><b>A–I</b>. Juvenile demyelination leads to impairment in PV interneuron maturation whereas adult demyelination induces a decrease in the excitability of PV interneurons. …”

Effect of AUT00201 (1 µM) on PV properties after adult demyelination. by Sara Hijazi (21656615)

Remyelination in adulthood leads to an incomplete restoration of PV interneuron properties. by Sara Hijazi (21656615)

“…<b>P</b>. Average action potential (AP) frequency in response to 0-650 pA current steps illustrating a significant decrease in PV interneuron firing frequency in remyelination (green) mice (<i>group x current two-way repeated measures: n = 25/19 cells from 8 mice per group: F(13,546) = 3.962, ***p < 0.001</i>). …”

Adult demyelination has no effect on PV interneuron’s firing rate or failures in autaptic responses. by Sara Hijazi (21656615)

AUT00201 (1 µM) can rescue AP width in cuprizone mice. by Sara Hijazi (21656615)

“…<p><b>A</b>. Bath application of AUT00201 1 µm decreased the rheobase of PV interneurons from cuprizone mice but not control mice (<i>group x AUT00201 two-way repeated measures: n = 12,13 cells from 4 mice per group: F(1,12) = 0.1816, p = 0.6775; AUT00201 effect: F(1,12) = 7.122, *p = 0.0205. …”

All data points from Fig 2. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 5. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 8. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 3. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 1. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 4. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 9. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 7. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

All data points from Fig 6. by Sara Hijazi (21656615)

“…<div><p>Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. …”

PRISMA flow chart of the screening process. by Mohamed R. Abdelraouf (21501468)

“…The analysis showed that pulsatile perfusion led to a significant decrease in creatinine level [MD = −0.14, 95% CI (−0.24, −.04), P < 0.004], lactate level [MD = −8.21, 95% CI (−13.16, −3.25), P < 0.001], hospital stay [MD = −1.38, 95% CI (−2.51, −0.25), P = 0.016], ICU stay [MD = −0.47, 95% CI (−0.82, −0.13), P = 0.007], intubation time [MD = −3.73, 95% CI (−5.42, −2.04), P < 0.001], and increase in creatinine clearance [MD = 10.08, 95% CI (3.36, 16.80), P < 0.003]. …”

Forest plot of liver function tests. by Mohamed R. Abdelraouf (21501468)

“…The analysis showed that pulsatile perfusion led to a significant decrease in creatinine level [MD = −0.14, 95% CI (−0.24, −.04), P < 0.004], lactate level [MD = −8.21, 95% CI (−13.16, −3.25), P < 0.001], hospital stay [MD = −1.38, 95% CI (−2.51, −0.25), P = 0.016], ICU stay [MD = −0.47, 95% CI (−0.82, −0.13), P = 0.007], intubation time [MD = −3.73, 95% CI (−5.42, −2.04), P < 0.001], and increase in creatinine clearance [MD = 10.08, 95% CI (3.36, 16.80), P < 0.003]. …”

Subgroup analysis of BUN based on pump type. by Mohamed R. Abdelraouf (21501468)

“…The analysis showed that pulsatile perfusion led to a significant decrease in creatinine level [MD = −0.14, 95% CI (−0.24, −.04), P < 0.004], lactate level [MD = −8.21, 95% CI (−13.16, −3.25), P < 0.001], hospital stay [MD = −1.38, 95% CI (−2.51, −0.25), P = 0.016], ICU stay [MD = −0.47, 95% CI (−0.82, −0.13), P = 0.007], intubation time [MD = −3.73, 95% CI (−5.42, −2.04), P < 0.001], and increase in creatinine clearance [MD = 10.08, 95% CI (3.36, 16.80), P < 0.003]. …”

Subgroup analysis of ICU Stay based on pump type. by Mohamed R. Abdelraouf (21501468)

“…The analysis showed that pulsatile perfusion led to a significant decrease in creatinine level [MD = −0.14, 95% CI (−0.24, −.04), P < 0.004], lactate level [MD = −8.21, 95% CI (−13.16, −3.25), P < 0.001], hospital stay [MD = −1.38, 95% CI (−2.51, −0.25), P = 0.016], ICU stay [MD = −0.47, 95% CI (−0.82, −0.13), P = 0.007], intubation time [MD = −3.73, 95% CI (−5.42, −2.04), P < 0.001], and increase in creatinine clearance [MD = 10.08, 95% CI (3.36, 16.80), P < 0.003]. …”

Subgroup analysis of eGFR based on pump type. by Mohamed R. Abdelraouf (21501468)

“…The analysis showed that pulsatile perfusion led to a significant decrease in creatinine level [MD = −0.14, 95% CI (−0.24, −.04), P < 0.004], lactate level [MD = −8.21, 95% CI (−13.16, −3.25), P < 0.001], hospital stay [MD = −1.38, 95% CI (−2.51, −0.25), P = 0.016], ICU stay [MD = −0.47, 95% CI (−0.82, −0.13), P = 0.007], intubation time [MD = −3.73, 95% CI (−5.42, −2.04), P < 0.001], and increase in creatinine clearance [MD = 10.08, 95% CI (3.36, 16.80), P < 0.003]. …”

GRADE evidence profile. by Mohamed R. Abdelraouf (21501468)

“…The analysis showed that pulsatile perfusion led to a significant decrease in creatinine level [MD = −0.14, 95% CI (−0.24, −.04), P < 0.004], lactate level [MD = −8.21, 95% CI (−13.16, −3.25), P < 0.001], hospital stay [MD = −1.38, 95% CI (−2.51, −0.25), P = 0.016], ICU stay [MD = −0.47, 95% CI (−0.82, −0.13), P = 0.007], intubation time [MD = −3.73, 95% CI (−5.42, −2.04), P < 0.001], and increase in creatinine clearance [MD = 10.08, 95% CI (3.36, 16.80), P < 0.003]. …”