Search alternatives:
significant hits » significant units (Expand Search), significant bias (Expand Search), significant anti (Expand Search)
sizes decrease » size increase (Expand Search), scores decreased (Expand Search)
hits increased » units increased (Expand Search), hifu increased (Expand Search), costs increased (Expand Search)
set decrease » step decrease (Expand Search), we decrease (Expand Search), mean decrease (Expand Search)
significant hits » significant units (Expand Search), significant bias (Expand Search), significant anti (Expand Search)
sizes decrease » size increase (Expand Search), scores decreased (Expand Search)
hits increased » units increased (Expand Search), hifu increased (Expand Search), costs increased (Expand Search)
set decrease » step decrease (Expand Search), we decrease (Expand Search), mean decrease (Expand Search)
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Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen.
Published 2023“…Compound 206 (1μM) significantly increased spheroid size relative to DMSO + CSE 3% control bronchospheres. …”
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Spheroid size changes due to primary mucus reduction hits and mucus changes due to primary swell hits.
Published 2023“…Compounds 56 (1μM), 85 (10μM), and 294 (1 and 10μM) significantly increased MUC5AC ratio compared to DMSO + CSE 3% control and were therefore filtered out of swell hit selection. …”
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