The global disease burden of <i><i>Klebsiella pneumoniae</i></i> associated LRI for both sexes in 204 countries and territories. (a) The number of DALYs in 2021; (b) The EAPC of DA... حسب Juanjuan Li (399633)

الموضوعات:

Global and national estimates of disability-adjusted life years (DALYs) due to <i>Klebsiella pneumoniae</i>-associated lower respiratory infections in 1990 and 2021. حسب Juanjuan Li (399633)

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DALYs rate and SDI across all regions between1990 and 2021 (a). DALYs rate across all countries in 2021 by SDI (b). DALYs disability-adjusted life years, SDI socio-demographic inde... حسب Juanjuan Li (399633)

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The number and ASR of deaths for <i>Klebsiella pneumoniae</i>-related LRI burden in 1990 and 2021, and its trends from 1990 to 2021. حسب Juanjuan Li (399633)

الموضوعات:

The global disease burden of <i><i>Klebsiella pneumoniae</i></i> associated LRI for both sexes in 204 countries and territories. (a) The number of deaths in 2021; (b) The EAPC of d... حسب Juanjuan Li (399633)

الموضوعات:

The number and ASR of DALYs for <i>Klebsiella pneumoniae</i>-related LRI burden in 1990 and 2021, and its trends from 1990 to 2021. حسب Juanjuan Li (399633)

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Raw data of Fig 2-Fig 13 in this study. حسب Wen Wen Zheng (17721404)

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DAS and Y27632 down-regulated the mRNA and protein expression of CK8-RhoA/ROCK1 pathway and up-regulated TJs expression in intestines of infected mice. حسب Wen Wen Zheng (17721404)

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qPCR analysis of CK8 knockdown affecting Clauding-1 mRNA expression. حسب Wen Wen Zheng (17721404)

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Molecular-docking simulation of the TsSPc–CK8 complex in Caco-2 cells. حسب Wen Wen Zheng (17721404)

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CK8 knockdown and ROCK1 inhibitor abolished rTsSPc-reduced TJs expression in Caco-2 monolayers by IFA. حسب Wen Wen Zheng (17721404)

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PAS staining of intestinal sections from <i>T. spiralis</i>-infected mice pretreated with DAS and Y27632. حسب Wen Wen Zheng (17721404)

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qPCR and Western blotting of CK8 knockdown blocking the rTsSPc-activated pathway and -reduced TJs expression. حسب Wen Wen Zheng (17721404)

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IFA, GST pull-down and Co-IP assay of specific binding between rTsSPc and CK8. حسب Wen Wen Zheng (17721404)

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Transcription and expression levels of CK8 in Caco-2 cells after CK8 gene was knocked down. حسب Wen Wen Zheng (17721404)

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qPCR and Western blotting of activation of CK8 receptor and RhoA/ROCK1 pathway proteins in Caco-2 cells treated with rTsSPc and IIL ES antigens. حسب Wen Wen Zheng (17721404)

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CK8 knockdown and ROCK1 inhibitor suppressed rTsSPc-induced disruption of the Caco-2 monolayer and blocked rTsSPc-promoted IIL invasion. حسب Wen Wen Zheng (17721404)

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Intraperitoneal injection protocol for inhibitors (A), inhibitors DAS and Y27632 reduced intestinal permeability (B) and intestinal adult worm burden (C) of infected mice. حسب Wen Wen Zheng (17721404)

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HE staining showed that DAS and Y27632 alleviated intestinal inflammation in <i>T. spiralis</i>-infected mice. حسب Wen Wen Zheng (17721404)

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The ROCK1 pathway inhibitor Y27632 prevented rTsSPc from activating the ROCK1 pathway and reducing TJs expression. حسب Wen Wen Zheng (17721404)

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