Supplementary file 1_HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.doc by Chelimuge Gong (22563287)

“…This activation of STAT3 was accompanied by a significant increase in the anti-apoptotic protein Bcl-2 and a decrease in pro-apoptotic Bax, alongside the suppression of the maladaptive factor HIF-1α. …”

Data Sheet 1_Near-infrared fluorescent nanoprobe enables noninvasive, longitudinal monitoring of graft outcome in RPE transplantation.pdf by Guanzhou Di (21287414)

“…Immunofluorescence analysis revealed a significant temporal increase in the proportion of macrophages with nanoprobe-labeled cells following transplantation. …”

Image 1_Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectives... by Haixiao Jiang (12013904)

“…</p>Results<p>Our findings showed a significant decrease in the diversity and even distribution of microorganisms in the HE group when compared to the HC and NE groups. …”

Image 4_Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.pdf by Youyi Wu (20786402)

“…</p>Results<p>The results revealed significant correlations between CD8+ T cell-related genes and immune-related pathways. …”

Table 1_Assessing the impact of non-protein nitrogen or rumen undegradable protein supplementation on rumen bacterial diversity and ruminal fermentation in grazing steers during th... by Ana Veronica Lino Dias (3985688)

“…</p>Results<p>GLU supplementation significantly increased supplement intake (p < 0.05) and tended to decrease the intake of forage NDF. …”

Model of the consequences of Ctu1 deficiency in zebrafish, figured by Figdraw. by Yangziwei Yu (20460661)

“…Inactivation of the CTU complex leads to a thermosensitive decrease with aberrant development in the nematode and fission yeast [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0315854#pone.0315854.ref015" target="_blank">15</a>]. …”

Table 2_Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.docx by Yue Li (102191)

“…Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. …”

Data Sheet 2_Effects of therapeutic horsemanship on caregiver stress scores of children with autism.pdf by Danielle C. Barron (21634196)

“…</p>Results<p>We observed caregivers experienced a statistically significant decrease (p=0.03) in their stress levels over a single semester of TH participation demonstrated by a reduction in DASS-21 stress subcategory (pre intervention mean 12.77 (SD = 9.95), post-intervention mean 8.62 (SD = 10.98). …”

Image 4_Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials... by Virginie Piffaut (22399978)

“…</p>Results<p>While ascorbic acid did not exhibit any efficacy versus its vehicle in limiting skin hyperpigmentation induced by HEV, the use of 2-MNG (0.5 or 1%) led to an early significant decrease in HEV-induced pigmentation, which was sustained until the end of the study, as evidenced by colorimetry and significantly scored by visual assessment. …”

DataSheet1_OsPDIL1-5: dual role in promoting growth and development while modulating drought stress tolerance in rice (Oryza sativa L.).docx by Jilin Chen (19847928)

“…This discovery highlights the importance of GDDT as a pleiotropic gene with significant implications for both plant growth and drought resistance. …”

Supplementary information files for "Incorporating fluid-structure interactions for modelling of pyramidal hollow microneedles for transdermal drug delivery" by Rahul Nadda (19435999)

“…<p dir="ltr">Supplementary files for article "Incorporating fluid-structure interactions for modelling of pyramidal hollow microneedles for transdermal drug delivery"<br><br>ollow microneedles (HMNs) have gained significant attention as a potential alternative to traditional hypo?…”

Table 4_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…Ten and five of these upregulated genes were classified into two significantly enriched KEGG pathways: cell cycle and progesterone-mediated oocyte maturation (q-value <0.05), respectively. …”

Image 3_Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials... by Virginie Piffaut (22399978)

“…</p>Results<p>While ascorbic acid did not exhibit any efficacy versus its vehicle in limiting skin hyperpigmentation induced by HEV, the use of 2-MNG (0.5 or 1%) led to an early significant decrease in HEV-induced pigmentation, which was sustained until the end of the study, as evidenced by colorimetry and significantly scored by visual assessment. …”

Image 5_Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.pdf by Youyi Wu (20786402)

“…</p>Results<p>The results revealed significant correlations between CD8+ T cell-related genes and immune-related pathways. …”

Table 4_Is takeout culture associated with rising colorectal cancer in young Chinese adults? An ecological analysis of GBD and CHNS data.xlsx by Ling Yao (16961)

“…Among non-neoplastic digestive diseases, inflammatory bowel disease showed the most pronounced decrease. In contrast, the burden of colorectal cancer has increased annually across all age groups. …”

Table 2_Global patterns and health impact of unintentional injuries among children and adolescents, 1990–2021.docx by Wei Wei (21173)

“…Among the five socio-demographic index (SDI) regions, the low-middle SDI region exhibited the most significant decrease in injury incidence. Regionally, from 1990 to 2021, the Caribbean experienced the largest relative increase in injury incidence (EAPC 0.25, 95% CI: −0.60 to 1.11). …”

Table3_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table 1_Association between eating behavior patterns and the therapeutic efficacy of GLP-1 receptor agonists in individuals with type 2 diabetes: a multicenter prospective observat... by Yuya Koide (22261300)

“…</p>Results<p>GLP-1RA therapy significantly reduced HbA1c, body weight, and body fat percentage at 12 months. …”

Experiments (Crystal violet assay). by Takanori Kitagawa (20727226)

“…YCW-H demonstrated significant anti-proliferative effects on MCF7 cells, reducing cell growth by 58.7% ± 6.9 even when physically separated from the cells by a plastic wall. …”

Image 5_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”