Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

DataSheet1_The OsGAPC3 mutation significantly affects grain quality traits and improves the nutritional quality of rice.docx by Bo Peng (273834)

“…The number and volume of type-II protein bodies in the endosperm of the OsGAPC3 mutants, and GPC increase significantly. We report significant increases in chalkiness area and degree, and decreases for starch content, gel consistency, and taste value. …”

Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

“…</p>Objective<p>This study aims to elucidate the clinical implications of concurrent AICDA and IKBKB homozygous variants in a pediatric patient diagnosed with hyper-IgM syndrome.</p>Methods<p>We present immunological and genetic analysis of a Tunisian patient with two homozygous variants of uncertain significance (VUSs) in the IKBKB and AICDA genes, suspected of causing hyper-IgM and immune deficiency. …”

Data Sheet 1_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Data Sheet 2_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Data Sheet 3_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

ERI Thresholds Between Adjacent Zones. by Mingyue Sun (4638535)

“…The transition and desert zones decreased by 49.7% and 37.9%, respectively. The ERI decreased and was strongly correlated with the OLS. …”

Location of the study area. by Mingyue Sun (4638535)

“…The transition and desert zones decreased by 49.7% and 37.9%, respectively. The ERI decreased and was strongly correlated with the OLS. …”

Random Forest structure with cross-validation. by Mingyue Sun (4638535)

“…The transition and desert zones decreased by 49.7% and 37.9%, respectively. The ERI decreased and was strongly correlated with the OLS. …”

Land use change from 1990 to 2020. by Mingyue Sun (4638535)

“…The transition and desert zones decreased by 49.7% and 37.9%, respectively. The ERI decreased and was strongly correlated with the OLS. …”

Geographic data. by Mingyue Sun (4638535)

“…The transition and desert zones decreased by 49.7% and 37.9%, respectively. The ERI decreased and was strongly correlated with the OLS. …”

Classification accuracy. by Mingyue Sun (4638535)

“…The transition and desert zones decreased by 49.7% and 37.9%, respectively. The ERI decreased and was strongly correlated with the OLS. …”

Data. by Michael C. Payne (2664379)

“…Using a generalized estimating equation model that accounted for age, sex, bednet use, and sentinel site, we found no significant difference in the effectiveness of the two treatment approaches (p = 0.845 for Mf and p = 0.332 for CFA). …”

Prescription data. by Dainty Ei (22265317)

“…Despite less restrictive measures in the first stage of the pandemic, Sweden experienced significant mental health consequences and changes in psychotropic medication prescribing.…”

Comparison of absolute and relative errors. by Lahoucine Tadoummant (21647670)

“…A significant reduction in both error types is observed, with the relative error |<i>X</i>_<i>r</i>| decreasing from approximately 10⁻¹ to 10⁻⁸. …”

Rate of convergence for relative errors. by Lahoucine Tadoummant (21647670)

“…A significant reduction in both error types is observed, with the relative error |<i>X</i>_<i>r</i>| decreasing from approximately 10⁻¹ to 10⁻⁸. …”

Ultrafine Particulate Matter Exacerbates the Risk of Delayed Neural Differentiation: Modulation Role of METTL3-Mediated m⁶A Modification by Rui Wang (52434)

“…By employing <i>N</i>6-methyladenosine (m⁶A) methylated RNA immunoprecipitation sequencing and bioinformatics, we identified <i>Zic1</i> as a key target of PM_0.1-induced developmental disturbances. …”

Data. by Chao Zhang (51048)

“…However, the reported rate of urticaria decreased significantly in post-LAW period(P = 0.043). …”

Upper-crust thermal evolution of the Patagonian Precordillera basement (Argentina): insights from fission track, (U-Th)/He thermochronology and geodynamic significance by Paulo Marcos (7459064)

“…Results thus indicate that one of the most significant exhumation event recorded in basement rocks of the Patagonian Andean foreland took place during the late Early Cretaceous – Paleocene stage.…”