Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria حسب Al-Sadeq, Duaa W.

"…This reduced activity is consistent with both in vitro and in silico evidence, which indicates that the L230Q mutation significantly decreases the overall protein’s stability, which in turn, may represent the underlying cause of its pathogenicity.…"
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Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy حسب Bhat, A.A.

"…Overall, this is a relatively unexplored field that could provide crucial insights into tumor immunology and encourage the effective application of modulatory cytokine-chemokine therapy to EC.…"
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Kappa-Distributed Electrons in Solar Outflows: Beam-Plasma Instabilities and Radio Emissions حسب Lazar, M.

"…Particle-in-cell (PIC) simulations confirm the inhibiting effects of (initially) Kappa-distributed electrons, but these minor effects in the linear and quasi-linear phases unexpectedly lead to significant decreases in the wave energy levels of the (primary) ES fluctuations near the plasma frequency and higher harmonics. …"
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Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) حسب Hamad, Anas

"…Background: In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …"
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function حسب Da'as, Sahar I.

"…We recently showed that four arrhythmogenic CaM mutations (N98I, D132E, D134H, and Q136P) significantly reduce the binding of CaM to RyR2. Herein, we investigate in vivo functional effects of these CaM mutations on the normal zebrafish embryonic heart function by microinjecting complementary RNA corresponding to CaMN98I, CaMD132E, CaMD134H, and CaMQ136P mutants. …"
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Screening of Qatari Microalgae and Cyanobacteria for Application in CO2 Utilization حسب Schipper, Kira

"…In Qatar, the prospect of using microalgae is very promising: high solar irradiance, large areas of non-arable land, and large amounts of CO2 sources make it an ideal place for algae cultivation. …"
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Gender Prespecified Sampling for Cost Control حسب Trung Le1, Kien

"…Without accounting for these contextual factors, survey designers risk decreasing the representativeness of the sample through sampling and nonresponse errors. …"
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Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study حسب Rajesh, Sharma

"…Tracheal, bronchus, and lung cancer (both sexes), breast cancer (among females), colon and rectum cancer (both sexes), stomach cancer (both sexes) and prostate cancer (among males) were among top-5 cancers in most Asian countries in terms of ASIR and ASMR in 2019 and cancers of liver, stomach, hodgkin lymphoma and esophageal cancer posted the most significant decreases in age-standardized rates between 1990 and 2019. …"
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling حسب Ghantous, Crystal M.

"…Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production. …"
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Glucose and transferrin liganded PLGA nanoparticles internalization in non-small cell lung cancer cells حسب Benammar, Sarra

"…Results: The results pointed to a significantly improved internalization rate of the liganded compared to PLGA NPs. …"
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Reduced vasorin enhances angiotensin II signaling within the aging arterial wall حسب Pintus, Gianfranco

"…The physical interaction between vasorin and TGF-β1 was significantly decreased in old vs. young VSMCs. Further, exposing young VSMCs to Ang II increased the levels of matrix metalloproteinase type II (MMP-2) activation and TGF-β1 downstream molecules p-SMAD-2/3 and collagen type I production up to the levels of old untreated VSMCs, and these effects were substantially inhibited by overexpressing vasorin. …"
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Novel electroless deposited corrosion — resistant and anti-bacterial NiP–TiNi nanocomposite coatings حسب Fayyad E.M.

"…Below and above this concentration as well as after the heat treatment, the improvement in the corrosion protection of the composite coatings slightly decreases. Besides, the NiP–TiNi NCCs have effective antibacterial properties as the cell viability of Escherichia coli decreases from 100 to 19%.…"
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Novel Electroless Deposited Corrosion - Resistant and Anti-Bacterial NiP-TiNi Nanocomposite Coatings حسب Fayyad, Eman

"…Below and beyond this concentration as well as after heat treatment, the improvement in the corrosion protection of the composite coatings slightly decreases. Besides, the NiP-TiNi NCCs have effective antibacterial properties as it decreased the cell viability of Escherichia coli from 100 to 19%.…"
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Silicon Enhances Morpho–Physio–Biochemical Responses in Arsenic Stressed Spinach (Spinacia oleracea L.) by Minimizing Its Uptake حسب Saleem, Muhammad Hamzah

"…Addition of Si into the soil significantly alleviated As toxicity effects on S. oleracea by improving photosynthetic capacity and ultimately plant growth. …"
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Network analysis of anxiety and depressive symptoms among quarantined individuals: Cross-sectional study حسب Abdul Karim, Mustafa

"…Results Participants with COVID-19 were significantly older and had a significantly higher proportion of males. …"
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Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway حسب Anwar, M. Akhtar

"…Here we determined the effects of an ethanolic extract of SF leaves on rings of isolated thoracic aorta from Sprague-Dawley rats. …"
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An exploratory social media intervention for perception and behavior on eating away from home: A cluster randomized trial in Chongqing, China حسب Tingting, Wu

"…The proportion of participants in the high-level knowledge and attitude group in the intervention group increased by 13% and 8.5% compared with the control group (p < 0.05). The effects of the intervention on the outcomes significantly changed over time, as demonstrated by the achieved statistical significance for knowledge and attitude score (p for group and time interaction <0.001) in the interaction between time and randomization groups. …"
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Electrochemical Investigation of C-Steel Corrosion Inhibition, In Silico, and Sulfate-Reducing Bacteria Investigations Using Pyrazole Derivatives حسب Shaban, Mahmoud M.

"…The current research shows important developments in producing highly effective anticorrosion and antimicrobial pyrazole derivatives.…"
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The Gender-Pay Gap and the Family in the Gulf: Root Causes, Implications and Policy Response حسب Al-Ahmadi, Hala

"…According to evidence it decreases family incomes and increases poverty. Although, women contribute significantly to the family's economic well-being, they continue to earn less than their male colleagues. …"
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High-intensity exercise training does not influence body weight but improves lipid oxidation in obese adults: A 6-week RCT حسب Jabbour, Georges

"…Moreover, for the training group, the homoeostasis model assessment of insulin resistance (HOMA-IR) index decreased significantly from the baseline value (p<0.01) and the control group value (p<0.01). …"
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