Table 3_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx حسب Tien Le (634791)

"…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…"

Image1_Neutrophil extracellular traps as immunofibrotic mediators in RA-ILD; pilot evaluation of the nintedanib therapy.tif حسب Aliki I. Venetsanopoulou (12197432)

"…On the other hand, nintedanib treatment decreased NETs and sC5b-9 levels in RA-ILD patients.…"

Data Sheet 2_Dietary composition and fasting regimens differentially impact the gut microbiome and short-chain fatty acid profile in a Pakistani cohort.xlsx حسب Farzana Gul (7119200)

"…Ramadan fasting also led to a significant increase in SCFAs including C7, iC4, and iC6, accounting for variability in microbial composition and phylogeny, respectively. …"

Table 2_Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018.docx حسب Huang Yu (5882174)

"…</p>Results<p>Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. …"

Image 7_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.tiff حسب Tien Le (634791)

"…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…"

Table 1_Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway.docx حسب Yuru Pang (20944667)

"…</p>Results<p>The results demonstrated that Ir-1 exhibited significant radiosensitizing effects on lung cancer cells. …"

Image 3_Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus.pdf حسب Guanfei Zhao (3815596)

"…</p>Results<p>Patients with SLE exhibited significantly decreased MMP-Low in some peripheral lymphocyte subsets. …"

Framework synthesis of zinc scale-up programs. حسب Keith Beam (20700854)

"…Our findings demonstrate the long-term success of the SUZY project and provide insights into best practices for impactful zinc scale-up programs including significant pre-launch implementation research addressing key knowledge gaps and partnering with research organizations. …"

Table 1_Apoptosis and autophagy promote Babesia microti infection in tick midguts: insights from transcriptomic and functional RNAi studies.docx حسب Songqin Chen (9625886)

"…Functional assays demonstrated that RNA interference (RNAi)-mediated knockdown of caspase-7, caspase-9, and ATG5 significantly reduced the burden of B. microti. Conversely, pharmacological induction of autophagy using rapamycin increased B. microti load, whereas inhibition with 3-methyladenine (3-MA) decreased B. microti load.…"

Figure 7 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain حسب Stamatia C. Vorri (19563842)

"…<p>Single-chain proximal IL7Rα CAR-T cells have decreased <i>in vivo</i> antileukemia activity. <b>A,</b> Schematic of the xenograft model. …"

Table 1_Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and interventio... حسب Giulia Marafioti (21163931)

"…Dynamic functional connectivity studies report reduced brain activity efficiency, while graph theory analyses show decreased network integration. Advanced neuroimaging techniques and machine learning (ML) approaches demonstrate significant promise in detecting subtle neural changes in SCD, with applications for early diagnosis and monitoring disease progression.…"

Data Sheet 1_Adjunctive esketamine in propofol-based sedation for gastrointestinal endoscopy: a systematic review and meta-analysis of randomized trials.docx حسب Jiazheng Qi (22679312)

"…No significant differences were found for hypertension, arrhythmias, PONV, recovery time or dizziness.…"

Supplementary file 1_Spatiotemporal monitoring in beidagang wetland using Landsat time-series images and Google Earth Engine during 2000–2022.docx حسب Xinyue Zhang (271120)

"…Frequent type conversions occurred between adjacent classes, with the most significant changes in Guanqi Lake. Despite declining wetland water volumes due to rising temperatures and reduced precipitation, ecological compensation measures, including functional zoning, water replenishment, and phragmites restoration, have continuously improved the wetland environment. …"

Table 1_Serum neurotransmitter analysis of motor and non-motor symptoms in Parkinson’s patients.docx حسب Yichun Fan (14295492)

"…Analysis of neurotransmitter metabolism revealed significant changes in the tryptophan (Trp) metabolic pathway in PD patients. …"

Data Sheet 1_BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.docx حسب Man Zhao (314232)

"…Furthermore, silencing BNIP3 leads to a significant reduction in mitochondrial damage and mtROS production. …"

Table 6_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.xls حسب Meizhi Liu (21898892)

"…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …"

Supplementary file 1_Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study.docx حسب Shuhan Zheng (18614305)

"…Background<p>The resurgence of pertussis has emerged as a significant global public health threat. Severe pertussis primarily affects infants and children and is often associated with serious complications or death.…"

Image 2_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis... حسب Yuchan Zhong (22518395)

"…The results showed that antioxidant supplementation significantly alleviated pelvic pain (continuous outcomes: SMD = −2.68; p < 0.00001; binary outcomes: RR = 9.31; p < 0.0001), dysmenorrhea (SMD = −1.77; p = 0.01; RR = 2.39; p = 0.03), and dyspareunia (SMD = −2.33; p = 0.01; RR = 5.40; p = 0.003), and significantly decreased peripheral blood malondialdehyde (MDA) levels (SMD = −7.58; p = 0.001). …"

Data_Sheet_1_Depression and health literacy among adolescents and adults in Germany: findings from two representative samples.pdf حسب Lars König (3440474)

"…Introduction<p>Depressive disorders constitute a significant public health challenge. Health literacy might be an important factor to consider in prevention strategies for depressive disorders, which is why this study aimed at exploring the association between depressive symptom levels and severity and health literacy, along with additional sociodemographic factors.…"

Data Sheet 1_RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking.pdf حسب Ye Li (290115)

"…ARL5B expression was significantly downregulated in treated Y79 and Weri-RB1 cells. …"