يعرض 20,061 - 20,080 نتائج من 23,503 نتيجة بحث عن '(( significant ((challenges decrease) OR (challenges case)) ) OR ( significant decrease decrease ))', وقت الاستعلام: 0.62s تنقيح النتائج
  1. 20061

    DataSheet1_Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, ran... حسب Yangfan Hou (8043884)

    منشور في 2024
    "…From baseline to day 91, mean difference between groups (MDBG) in the reduction of TNSS was -1.1 (-2.2, -0.1) (P = 0.04); MDBG in the increment of TNF-α was 7.1 pg/ml (95% CI: 0.8, 13.4, P = 0.03); the INF-γ level was significantly increased (P = 0.01), whereas that of IL-17 (P = 0.005) was significantly decreased in the test group, whilst mean difference within groups was not statistically significant in the placebo group; MDBG in the increment of acetate was 12.4% (95% CI: 7.1%, 17.6%, P <0.001). …"
  2. 20062

    Table 1_Evaluating the Implementation of fan-beam CT-guided online adaptive re-planning in definitive cervical cancer radiotherapy.docx حسب Shuai Sun (775057)

    منشور في 2025
    "…This approach has shown significant improvements in dose distribution and the potential to provide clinical benefits by reducing acute toxicity.…"
  3. 20063

    Experimental protocol and behavioral evidence of perceptual learning. حسب Sarit F.A. Szpiro (21094755)

    منشور في 2025
    "…The shaded area represents the standard error of the mean. Significant clusters for the main effect of PRE/post training, as determined by cluster mass permutation two-tailed tests, are indicated with rectangles (p < 0.05 and p < 0.1). …"
  4. 20064

    Data Sheet 2_Cellular effects of splenectomy on liver regeneration after 70% resection.pdf حسب Andrey Elchaninov (3122742)

    منشور في 2025
    "…Splenectomy also correlated with decreased rates of Ly6C+ monocyte and Ly6G+ leukocyte migration. …"
  5. 20065

    Genetic and structural factors contributing to the dominance and persistence of goose astrovirus type 2 حسب Peng Jiang (16544)

    منشور في 2025
    "…<p>Goose astrovirus (GoAstV) has emerged as a significant pathogen affecting the goose industry in China, with GoAstV-2 becoming the dominant genotype since 2017. …"
  6. 20066

    Care quality. حسب Youssef Hbid (18803761)

    منشور في 2025
    "…<div><p>Background and aim</p><p>The COVID-19 pandemic imposed significant pressures on healthcare services such as stroke care. …"
  7. 20067
  8. 20068

    Glucagon-like peptide 1 receptor agonists modestly reduced low-density lipoprotein cholesterol and total cholesterol levels independent of weight reduction: a meta-analysis and met... حسب Frederick Berro Rivera (12679463)

    منشور في 2024
    "…</p> <p>GLP-1RA treatment modestly decreased LDL-C and TC but did not significantly affect triglycerides, VLDL-C, or HDL-C.…"
  9. 20069

    Image 1_Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity.tiff حسب Matthew C. Austin (20633168)

    منشور في 2025
    "…Gene ontology analysis revealed a significant upregulation of pathways involved in inflammatory processes, response to ER stress, and the ER-associated degradation pathway. …"
  10. 20070

    Data Sheet 1_Cellular effects of splenectomy on liver regeneration after 70% resection.pdf حسب Andrey Elchaninov (3122742)

    منشور في 2025
    "…Splenectomy also correlated with decreased rates of Ly6C+ monocyte and Ly6G+ leukocyte migration. …"
  11. 20071

    Image 1_Kidney sparing surgery versus radical nephroureterectomy in upper tract urothelial carcinoma: a meta-analysis and systematic review.tif حسب Leqing Zhou (20981021)

    منشور في 2025
    "…In the comparison between the endoscopic management (EM) and RNU groups, EM was associated with worse overall survival outcomes (HR,1.40; 95%CI,1.08-1.82; P=0.01) based on multivariable Cox regression analysis, and the upper tract recurrence rate (OR,39.06; 95%CI, 14.55-104.85; P<0.00001) was significantly higher in the EM group. On the other hand, in patients treated with KSS, postoperative renal function as measured by eGFR increased by 0.4ml/min/1.73 m<sup>2</sup>, while it decreased by 11.4ml/min/1.73 m<sup>2</sup> in the RNU group (WMD, 11.81 ml/min/1.73 m<sup>2</sup>; 95%CI,9.06-14.56; P<0.0001).…"
  12. 20072

    Data Sheet 1_The impact of immune checkpoint inhibitors on prognosis in unresectable hepatocellular carcinoma treated with TACE and lenvatinib: a meta-analysis.zip حسب Wei Zhang (405)

    منشور في 2025
    "…The TACE+L+I group had a significantly higher incidence of hypothyroidism compared to the TACE+L group (RR = 1.81, 95%CI:1.20, 2.71, p<0.05), but there was no significant difference in other adverse events, such as hypertension, diarrhea, hand-foot syndrome, fatigue, elevated AST, elevated ALT, decreased appetite, hypothyroidism, abdominal pain, thrombocytopenia, rash, and nausea.…"
  13. 20073

    Outcomes at discharge. حسب Youssef Hbid (18803761)

    منشور في 2025
    "…<div><p>Background and aim</p><p>The COVID-19 pandemic imposed significant pressures on healthcare services such as stroke care. …"
  14. 20074

    Data Sheet 1_Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.docx حسب Omkar B. Ijare (22274167)

    منشور في 2025
    "…The CE-to-cholesterol ratio of 0.44 in the recurrent tumor suggests significant cholesterol esterification during malignant progression.…"
  15. 20075

    Table10_Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization.xlsx حسب Yifang He (18126257)

    منشور في 2024
    "…</p>Conclusions<p>Our bioinformatics combined with MR analysis revealed that CD93, CYBB, DOCK8, IRF1, MBOAT1, MYO1F, NLRP1, NOD2, PIK3R1 increase the risk of PCOS, while PTER decreases the risk of PCOS. This discovery has implications for clinical decision-making in terms of disease diagnosis, prognosis, treatment strategies, and opens up novel avenues for drug development.…"
  16. 20076

    Data Sheet 2_Effect of thyme-ivy syrup on antiviral immune response in patients with mild COVID-19: a prospective, open-label, randomized pilot study.docx حسب Stephanie Dauth (13274397)

    منشور في 2025
    "…Significant between-group differences were observed for changes in some parameters at day 4 (e.g., IL-10) and day 14. …"
  17. 20077

    Image 1_Association between daily variations in the levels of atmospheric O3, PM2.5, and NO2 and the frequency of hospital visits due to respiratory diseases and hypertension in Me... حسب Elizabeth Vega (13793101)

    منشور في 2025
    "…Background<p>Environmental pollution is a significant public health issue in Mexico City. Patients with respiratory or cardiovascular diseases such as asthma or hypertension often experience exacerbations triggered by environmental factors. …"
  18. 20078

    Table1_Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization.xlsx حسب Yifang He (18126257)

    منشور في 2024
    "…</p>Conclusions<p>Our bioinformatics combined with MR analysis revealed that CD93, CYBB, DOCK8, IRF1, MBOAT1, MYO1F, NLRP1, NOD2, PIK3R1 increase the risk of PCOS, while PTER decreases the risk of PCOS. This discovery has implications for clinical decision-making in terms of disease diagnosis, prognosis, treatment strategies, and opens up novel avenues for drug development.…"
  19. 20079

    Data Sheet 1_Efgartigimod for generalized myasthenia gravis in the extreme elderly (≥80 years): a multicenter retrospective real-world study.pdf حسب Ye Hong (2580841)

    منشور في 2025
    "…At week 4 (1week after the final infusion), the study showed significant reductions in all efficacy measurements: MG-ADL scores decreased by 52.2% ± 30.8% (from 10.9 ± 2.7 to 3.6 ± 2.1), QMG scores by 36.6% ± 28.4% (from 18.2 ± 7.0 to 11.7 ± 8.3), MGC scores by 48.2% ± 33.4% (from 17.8 ± 7.5 to 9.0 ± 8.6). …"
  20. 20080

    Data sources and descriptions. حسب Zeduo Zou (21672789)

    منشور في 2025
    "…As the results show, during the study period: (1) Temporal Trends: annual PM2.5 concentrations exhibited significant declines, with BTH decreasing from 1004.71 μg/m<sup>3</sup> (2006) to 528 μg/m<sup>3</sup> (2020), YRD from 1434.81 μg/m<sup>3</sup> (2008) to 621 μg/m<sup>3</sup>, and PRD from 405.02 μg/m<sup>3</sup> (2007) to 292 μg/m<sup>3</sup>. …"