Dissecting the signaling pathways regulating the vascular endothelial growth factor (VEGF) in brain tumor cells. (c2017) حسب Nicolas, Samer Michel

"…Moreover, when the astrocytoma cells were subjected to hypoxia at different times, we detected a significant increase in pERK. …"
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The anti-neoplastic activity of novel platinum II and IV complexes against A549 lung cancer cells حسب Al Sayegh, Rouba

"…Data revealed a significant drop in procaspase 3 and a significant increase in Bax/Bcl2 ratio, Cytochrome c, Parp and procaspase 8. …"
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Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells حسب Sara Al Tamimi (9692615)

"…Furthermore, we observed the cell death pathway by the apoptosis marker Annexin-V which showed non-significant results, while the exposure of AgCu-NP in MCF-7 cells leads to toxicity and also caused significant increase in MMP-9 level, which suggests the cell death may be associated with other pathways such as autophagy and oxidative stress related.…"

Performance evaluation of interrupted and hybrid channel heat sinks for a triple junction high concentrator photovoltaic cell حسب Muhammad Usman Sajid (14778232)

"…The results reveal that the hybrid channel design (Geometry F) significantly reduces the maximum solar cell temperature from 82 °C to 78 °C at CR = 1500 and Re = 400, achieving up to a 39.5 % increase in the Nusselt number compared to the conventional straight channel design (Geometry A). …"

Targeting acute myeloid leukemia cells with novel photosensitive ruthenium-based metal-organic compounds. (c2015) حسب Azar, Daniel Fadi

"…Of the four final complexes Ru-II3, Ru-II2-III, Ru-II-III2 and Ru-III3, only Ru-II3 and Ru-II2-III have shown significant activity against all tested cell lines in the dark, whereas photo-activation against ML2 has shown a marked increase of potency of all four complexes, even those shown to be biologically inert in the dark, reaching IC50 values in the nM range. …"
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Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59 حسب Ramada R. Khaswaneh (22224544)

"…Preserving the level of Factor H and CD59 in MSCs has significant clinical implication to increase their retention rate in hypoxic conditions and prolong their survival.…"

Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway حسب Shilpa Kuttikrishnan (3520079)

"…Overall, our findings demonstrated that NSP‐B induces caspase‐dependent apoptosis, increases cell damage, and suppresses MM cell proliferation while improving the cytotoxic impact of BTZ. …"

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes حسب Colleen A. Lopez (18520071)

"…In EHT, FAO was significantly higher than in monolayer cells or those on static scaffolds and could be further increased by culture with oleate and WY-14643. …"

<i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells حسب Nouralhuda Alateyah (21363215)

"…TI significantly suppressed BC cell growth, inhibited migration and invasion and induced apoptosis. …"

Modulation of Human Valve Interstitial Cell Phenotype and Function Using a Fibroblast Growth Factor 2 Formulation حسب Najma Latif (250130)

"…Some VICs and some valve endothelial cells expressed FGF2 in valve tissue and this expression was increased in calcified valves. …"

Development of a Flexible Framework Multi-Design Optimization Scheme for a Hand Launched Fuel Cell-Powered UAV حسب Al Rayes, Zaid

"…This paper presents different methods for the design of a hand-launchable, fixed wing, fuel cell-powered unmanned aerial vehicle (UAV) to maximize flight endurance during steady level flight missions. …"
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Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line حسب Toutounji, Mohamad

"…DSS treatment significantly reduced the transepithelial electric resistance (TEER) and increased the epithelial permeability of Caco-2 cells, without affecting their viability. …"
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer حسب El Mais, Nour

"…Finally, we looked at the effect of HuArgI (Co)-PEG5000 on 3D motility of the ovarian cancer cell line, using a collagen based assay. It showed that SKOV3 cell line does not show significant invasiveness to collagen. …"
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Investigation of Groundwater Depletion in the State of Qatar and Its Implication to Energy Water and Food Nexus حسب Hazrat Bilal (7367477)

"…Long-term temperature data indicates that the annual mean temperature increased significantly by 1.02 °C between 1987 and 2016, while total rainfall exhibited a slight decreasing trend. …"

12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase حسب Amira Othman (380131)

"…ROS generation and NOX2 expression were also measured in mice retinas. 12- and 15- HETE significantly increased permeability and reduced TER and ZO-1expression in REC. …"

Introducing a Novel Figure of Merit for Evaluating Stability of Perovskite Solar Cells: Utilizing Long Short-Term Memory Neural Networks حسب Zahraa Ismail (22457644)

"…The comparative analysis of model complexity confirmed that increasing the sophistication of the LSTM model significantly enhances predictive accuracy and generalization capabilities. …"

Immunoprofile of childhood diabetes حسب Meritxell Espino-Guarch (15430868)

"…In all clinical phenotypes (obese, Pre-diab, T2D and T1D) CD4+ Treg cells showed increased expression of CD49d in comparison to controls, whereas in Tcon cells differences only were observed in the T2D group. …"

Novel Platinum II and Platinum IV Complexes Exhibit An Anti-Neoplastic Potential Against A549 Cancer Cell Line حسب Baz, Joy

"…Treatment with Pt II and Pt IV also showed significant amounts of free radical production and increased DNA damage. …"
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The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma حسب Sarah A. Elkourashy (21632903)

"…<h3>Background</h3><p dir="ltr">Gut microbiota has emerged as a critical mediator of immune homeostasis and cancer biology. Increasing evidence suggests that gut dysbiosis may play a significant role in the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the most common and aggressive subtype of non-Hodgkin lymphoma (NHL). …"

Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro حسب Khalife, Rana

"…The reduction in proliferation was significantly dose- and time-dependent. After determining the best combination (40 µM thymoquinone and 0.6 µM topotecan), cell proteins were extracted after treatment, and the expression levels of B-cell lymphoma 2 and of its associated X protein, proteins p53 and p21, and caspase-9, caspase-3, and caspase-8 were studied by Western blot. …"
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