Showing 7,161 - 7,180 results of 9,384 for search '(( significant ((changes decrease) OR (largest decrease)) ) OR ( significant genes decrease ))', query time: 0.59s Refine Results
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    N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance by Lin-na Li (20442989)

    Published 2024
    “…Combined analysis of RNA-seq and MeRIP-seq showed 81 hypermethylated and up-regulated genes. Among the six candidate genes in the PI3K-signaling pathway, THBS1 was the most significantly differentially expressed and hypermethylated. …”
  8. 7168

    Analyses of directed phase lag index (dPLI [44]) for excitatory/inhibitory (E/I) ratios with respect to pyramidal (Pyr) and parvalbumin (PV) populations (<i>A</i>) and Pyr and soma... by Nobuhiko Wagatsuma (494052)

    Published 2025
    “…A change in E/I ratios caused by changing between specific subtypes of inhibitory and Pyr populations modulated the dominant direction of flows between PV and Pyr populations. …”
  9. 7169

    Supplementary Material for: Efficacy and safety of finerenone in Asian patients with type 2 diabetes and chronic kidney disease: A FIDELITY analysis by figshare admin karger (2628495)

    Published 2025
    “…Change in urine albumin-to-creatinine ratio (UACR) from baseline to month 4 and eGFR slopes were also assessed. …”
  10. 7170

    DataSheet1_Morinda officinalis iridoid glycosides, as an inhibitor of GSK-3β, alleviates rheumatoid arthritis through inhibition of NF-κB and JAK2/STAT3 pathway.docx by Yi Shen (152956)

    Published 2024
    “…Interestingly, the plant metabolites in MOIG had a good affinity with GSK-3β, and inhibition of GSK-3β attenuated the effects of MOIG on FLSs. Knockdown GSK-3β gene could inhibit the paw swelling and inflammatory indicators, decrease the arthritis score and synovial hyperplasia, reduce the phosphorylation of p65 and STAT3 in AA mice, thereby suppressing the NF-κB and STAT3 signaling activation, and MOIG treatment had no significant effects on AA mice with si-GSK-3β.…”
  11. 7171

    Metabolic flux analysis revealed key roles of ArcB in ADI pathway and IlvC in BCAA biosynthesis during <i>streptococcus suis</i> anaerobic growth and infection by Hao Tang (44155)

    Published 2025
    “…Transcriptomic analysis found a significant suppression of many central metabolic genes during anaerobic growth of <i>S. suis</i>. …”
  12. 7172

    <b>Metabolic flux analysis revealed </b><b>key roles of </b><b>ArcB</b><b> in ADI pathway and IlvC in BCAA </b><b>biosynthesis </b><b>during </b><b><i>Streptococcus suis</i></b><b>... by Hao Tang (21218903)

    Published 2025
    “…Transcriptome analysis found a significant suppression of many central metabolic genes during anaerobic growth of <i>S. suis</i>. …”
  13. 7173

    Data Sheet 1_Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis.zip by Dongmei Yuan (291583)

    Published 2025
    “…In the GPL metabolism and AA metabolism pathways, the transcription levels of genes such as phospholipase A2 (PLA2) family enzymes, cyclooxygenase-2 (Cox-2), arachidonate 5-lipoxygenase (Alox5), and hematopoietic prostaglandin D synthase (Hpgds), all of which regulate phospholipid hydrolysis and lipid mediator production, were significantly increased. …”
  14. 7174

    Supplementary file 1_Mechanism of soil microbial community degradation under long-term tomato monoculture in greenhouse.docx by Menglu Li (4458208)

    Published 2025
    “…PLS-PM model identified the accumulation of soil organic matter (SOM), nitrogen (N), and phosphorus (P) as key drivers of microbial community restructuring. Functional gene predictions based on 16S rRNA sequencing indicated that the expression of genes related to carbon (tktA/tktB, accA, acsB, cooS/acsA, ppc) and nitrogen (pmoA-amoA, nxrA, hao, nasA, nasB, gdh, ureC, narG, nirB, nirK, norB, nosZ) transformation were decreased. …”
  15. 7175

    Supplementary Material for: Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis by figshare admin karger (2628495)

    Published 2025
    “…RNA sequencing identified 905 DEGs in IgAN patients, with significant enrichment in neutrophil and NETosis pathways. …”
  16. 7176

    Data Sheet 1_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.docx by Jingjing Chen (293564)

    Published 2025
    “…Finally, qRT-PCR confirmed the differential expression of key genes in clinical samples.</p>Results<p>We identified 25 ribosome biogenesis-related differentially expressed genes, which were significantly enriched in RNA degradation and rRNA processing. …”
  17. 7177

    Presentation 1_Gender and age differences in the global burden of peptic ulcers: an analysis based on GBD data from 1990 to 2021.zip by Ruirui Tan (21188585)

    Published 2025
    “…In terms of future trends, the global incidence of PU is projected to continue decreasing over the next 15 years. The global prevalence is expected to improve, while PU-related mortality is likely to plateau without significant increases or decreases.…”
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    Table_1_Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy.docx by Federica Cagnasso (19834890)

    Published 2024
    “…In iPLE dogs, oleic acid (p = 0.044), stearic acid (p = 0.013), erucic acid (p = 0.018) and nervonic acid (p = 0.002) were significantly decreased at T1. At T0, cholesterol and lathosterol (p < 0.0001) were significantly higher in iPLE dogs compared to healthy dogs, while total measured phytosterols were significantly lower (p = 0.001). …”
  19. 7179

    Table_2_Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy.xlsx by Federica Cagnasso (19834890)

    Published 2024
    “…In iPLE dogs, oleic acid (p = 0.044), stearic acid (p = 0.013), erucic acid (p = 0.018) and nervonic acid (p = 0.002) were significantly decreased at T1. At T0, cholesterol and lathosterol (p < 0.0001) were significantly higher in iPLE dogs compared to healthy dogs, while total measured phytosterols were significantly lower (p = 0.001). …”
  20. 7180

    Table2_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease... by Juan Tang (437969)

    Published 2024
    “…Additionally, we calculated annual percentage changes spanning ages 15 - 19 to 95 + years, denoted as local drifts. …”