Data Sheet 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx by Jingjing Zhou (179820)

“…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …”

Molecular hydrogen mitigates NEMP-induced male reproductive cells apoptosis via scavenging ROS by Long Ma (133810)

“…However, intervention with molecular hydrogen significantly mitigated this damage. Specifically, molecular hydrogen reduced the production of ROS and restored mitochondrial function, thereby alleviating oxidative stress and apoptosis. …”

Image3_Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.tif by Chao Bai (4428472)

“…Sensitivity analyses showed no significant heterogeneity or pleiotropy.</p>Conclusion<p>In summary, this research uncovered a genetic causal relationship between heightened MMP-16 levels and reduced MMP-2 concentrations, and DN risk. …”

Table1_Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.docx by Chao Bai (4428472)

“…Sensitivity analyses showed no significant heterogeneity or pleiotropy.</p>Conclusion<p>In summary, this research uncovered a genetic causal relationship between heightened MMP-16 levels and reduced MMP-2 concentrations, and DN risk. …”

Data Sheet 1_Beta tACS of varying intensities differentially affect resting-state and movement-related sensorimotor power.docx by Kym Wansbrough (19711762)

“…For the resting-state, none of the real stimulation intensities induced significant changes in beta power relative to sham. …”

Supplementary file 1_Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity.docx by Min-qiang Bao (21570074)

“…</p>Results<p>AF patients had significantly lower MoCA scores. PSD analysis showed increased δ and θ and decreased α and β activity. …”

Table 1_A cross-sectional survey about behavior of wearing condoms among college students who engage in sexual activity: the mediating role of attitudes of preventive behavior.docx by Li Qi (575782)

“…No significant correlation was detected between PIR and APB (p ≥ 0.05), while PBPB and APB were significantly positively and PDPB and APB significantly negatively correlated (p < 0.05). …”

Supplementary file 1_Persistent burden and health inequalities of disease in women of childbearing age attributable to Intimate Partner Violence, 1990–2021.docx by Yingda Song (15410321)

“…Aims<p>Intimate Partner Violence (IPV) presents a significant global public health issue, particularly affecting women of childbearing age (WBCA). …”

Table 1_Multi-omics analyses reveal altered gut microbial thiamine production in obesity.xlsx by Yu Xia (8822)

“…</p>Results<p>Metabolomic analysis identified significantly lower levels of fecal thiamine in individuals with obesity (P_Wilcoxon < 0.001). …”

Data Sheet 1_Multi-omics analyses reveal altered gut microbial thiamine production in obesity.pdf by Yu Xia (8822)

“…</p>Results<p>Metabolomic analysis identified significantly lower levels of fecal thiamine in individuals with obesity (P_Wilcoxon < 0.001). …”

ALKBH5 induces macrophage activation to promote renal fibrosis via Retnla by Long Zheng (694761)

“…Macrophage-specific ALKBH5 knockout could significantly alleviate renal fibrosis in UUO mice and decrease the infiltration of macrophages in the kidneys. …”

Clinical and Imaging Characteristics of Posterior Scleritis in Children by Ayala Katzir (20605679)

“…Retinal nerve fiber layer (RNFL) was thickened in all examined eyes (mean±SD 136.2 ± 28.4 µm) at presentation and it significantly decreased with treatment (109.8 ± 8.2 µm two months later). …”

Data Sheet 1_Genome-wide development of SSR molecular markers for modern sugarcane cultivars.docx by Yi Xu (131145)

“…Among different repeat types, the number of mononucleotide repeats (620, 901) and dinucleotide repeats (238, 261) was the largest, accounting for 81.45% of the total number of SSR loci, and the number of SSR decreases with the increase of the number of SSR repeat motifs. …”

<b>Triptolide alleviates </b><b>cognitive</b><b> impairment via </b><b>autophagy</b><b> and Akt/mTOR/p70S6K pathway in an APP/PS1 Alzheimer’s disease mouse model</b> by xinyao Qi (21686459)

“…Notably, TP treatment led to a reduction in hippocampal Aβ1-40 level, suggesting a decrease in Aβ neuropathology. At the molecular level, TP normalized autophagic activity, evidenced by reduced LC3 II/ LC3 I ratios and Beclin-1 expression. …”

Table 1_Photosynthetic characteristics of Paris polyphylla var. chinensis in response to different light intensities and soil water contents.xlsx by Yaling Zhang (1687540)

“…It was also observed that treatment with low soil water content (20%) significantly reduced Pn and LUE, while increasing stomatal conductance (gs) and water use efficiency (WUE). …”

Data Sheet 1_Yeast cell wall derivatives as a potential strategy for modulating oral microbiota and dental plaque biofilm.docx by Torsten P. M. Scheithauer (10950975)

“…</p>Conclusion<p>This study has demonstrated the potential of yeast cell wall derivatives to positively impact oral health by significantly reducing biofilm density, modulating the oral microbial composition, and decreasing the production of short-chain fatty acids. …”

Supplemental file for Training alters cytokine and soluble receptor responses by Jeremy Ducharme (20174820)

“…In the trained group, these cytokine changes were accompanied by a marked increase in the expression of soluble receptors known to inhibit cytokine-mediated signaling, such as sIL-1RII, sGP130, sTNFRI, sTNFRII, sVEGFR1, and sVEGFR2, indicating reduced cytokine bioavailability. …”

Exploring cardiac vector propagation in acute myocardial infarction: a spatial velocity perspective by Tania Ghosal (20445665)

“…Significant vector changes were found in the Y-Axis in IWMI (<i>p</i> = 0.005) and X-Axis in cases of AWMI (<i>p</i> = 0.02), as compared to controls. …”

Table 1_Microbial diversity and community assembly in heavy metal-contaminated soils: insights from selenium-impacted mining areas.xlsx by Zhiyong Wang (313131)

“…Our results showed that Se and other heavy metal contamination significantly altered microbial community composition, favoring metal-tolerant phyla such as Proteobacteria, Actinobacteriota and Firmicutes, while reducing the abundance of sensitive groups like Acidobacteriota and Chloroflexi. …”

Table 2_Microbial diversity and community assembly in heavy metal-contaminated soils: insights from selenium-impacted mining areas.docx by Zhiyong Wang (313131)

“…Our results showed that Se and other heavy metal contamination significantly altered microbial community composition, favoring metal-tolerant phyla such as Proteobacteria, Actinobacteriota and Firmicutes, while reducing the abundance of sensitive groups like Acidobacteriota and Chloroflexi. …”