The level of miRNA 221 in the myocardium of MIRI mice was decreased. by Hongyu Li (1332669)

The heart rate was similar among the groups. by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

S1 File - by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

Primer sequences for RT-qPCR. by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

Altered expression of genes related to Ca²⁺ cycling or myocardial contraction. by Hongyu Li (1332669)

PLB is a target gene of miRNA 221. by Hongyu Li (1332669)

miRNA 221 improved left ventricular contractile function in MIRI mice. by Hongyu Li (1332669)

miRNA 221 alleviated calcium overload in myocardium and inhibited the expression of apoptosis-related genes in MIRI mice. by Hongyu Li (1332669)

miRNA 221 alleviated myocardial injury and inhibited apoptosis and necrosis of cardiac cells in MIRI mice. by Hongyu Li (1332669)

(a) M-K test of annual average water level in Caspian Sea (unformatted fit (UF) and underidentification bias (UB) is positive and reverse order in the time series respectively; ɑ i... by Zihao Duan (17403792)

Linear covariate analysis of prognostically significant metabolites. Presenting the effect sizes of metabolites that showed significant differences among prognostic groups in ICU-t... by Emir Matpan (21655811)

(a) Surface area and volume change with water level; (b) Topographic changes in the Caspian Sea. by Zihao Duan (17403792)

Water level changes in the foresight scenarios. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Water level changes in the Caspian Sea. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Methods used to extract shoreline changes. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Average of % peptides counts for different classes of proteins at different germination time points and significant p-value indicated as compared to soaked sample (*p< 0.05, **p<0.... by Indrani Bera (804948)

Coastal area changes during the period 1985–2023. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Average % peptides counts for different classes of proteins at different germination time points and significant p-value indicated as compared to soaked sample (*p< 0.05, **p<0.01,... by Indrani Bera (804948)

Average of % peptides counts for different classes of proteins at different germination time points and significant p-value indicated as compared to soaked sample (*p< 0.05, **p<0.... by Indrani Bera (804948)

(a) Change rates were calculated for each transect along the coastlines from 1985 to 2023; (b) Coastline change rates of the Caspian Sea based on the EPR and LRR. by Zihao Duan (17403792)