The level of miRNA 221 in the myocardium of MIRI mice was decreased. by Hongyu Li (1332669)

The heart rate was similar among the groups. by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

S1 File - by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

Primer sequences for RT-qPCR. by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

Altered expression of genes related to Ca²⁺ cycling or myocardial contraction. by Hongyu Li (1332669)

PLB is a target gene of miRNA 221. by Hongyu Li (1332669)

miRNA 221 improved left ventricular contractile function in MIRI mice. by Hongyu Li (1332669)

miRNA 221 alleviated calcium overload in myocardium and inhibited the expression of apoptosis-related genes in MIRI mice. by Hongyu Li (1332669)

miRNA 221 alleviated myocardial injury and inhibited apoptosis and necrosis of cardiac cells in MIRI mice. by Hongyu Li (1332669)

Inhibition of LDHA leads to decreased ATP, reduced AKT phosphorylation, and enhanced chemotherapy sensitivity to LBP in A549 and NCL-H1975 cells. by Siyu Yuan (7425719)

Overview of the parameters used in the model. by Albertus Constantijn Sloof (20405090)

“…</p><p>Conclusions</p><p>The findings highlight the critical role of timely vaccination interventions in outbreak settings, demonstrating that even modest coverage levels can markedly decrease the spread of CHIKV. This study underscores the importance of preparedness, early detection and adaptive response capabilities to manage emerging infectious diseases in urban centres, advocating for strategic vaccine stockpiling and rapid deployment mechanisms to enhance public health outcomes.…”

Mortality rates per lifecycle stage [28]. by Albertus Constantijn Sloof (20405090)

“…</p><p>Conclusions</p><p>The findings highlight the critical role of timely vaccination interventions in outbreak settings, demonstrating that even modest coverage levels can markedly decrease the spread of CHIKV. This study underscores the importance of preparedness, early detection and adaptive response capabilities to manage emerging infectious diseases in urban centres, advocating for strategic vaccine stockpiling and rapid deployment mechanisms to enhance public health outcomes.…”

Schematic representation of the study protocol. by Neng Pan (5262032)

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Baseline characteristics. by Neng Pan (5262032)

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Comparison within groups. by Neng Pan (5262032)

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Comparison before and after the experiment in each group. by Neng Pan (5262032)

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Data ste. by Neng Pan (5262032)

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Comparison of data after the experiment. by Neng Pan (5262032)

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Correlation diagram of each parameter in each group. by Neng Pan (5262032)

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Recruitment process. by Neng Pan (5262032)

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