بدائل البحث:
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
clinical decrease » clinical case (توسيع البحث), linear decrease (توسيع البحث), clinical areas (توسيع البحث)
clinical disease » tropical disease (توسيع البحث), clinical cases (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
clinical decrease » clinical case (توسيع البحث), linear decrease (توسيع البحث), clinical areas (توسيع البحث)
clinical disease » tropical disease (توسيع البحث), clinical cases (توسيع البحث)
-
821
-
822
-
823
-
824
-
825
-
826
-
827
-
828
-
829
-
830
-
831
Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms
منشور في 2025"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"
-
832
Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms
منشور في 2025"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"
-
833
Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms
منشور في 2025"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"
-
834
-
835
Downregulation of <i>TcPiezo1</i> expression decreases Ca<sup>2+</sup> entry in <i>T. cruzi.</i>
منشور في 2025"…(B) Downregulation of <i>TcPiezo1</i> expression showed a significant decrease of intracellular Ca<sup>2+</sup> (+Tet). …"
-
836
-
837
-
838
-
839
-
840