يعرض 821 - 840 نتائج من 36,983 نتيجة بحث عن '(( significant ((clinical decrease) OR (clinical disease)) ) OR ( significant decrease decrease ))', وقت الاستعلام: 0.69s تنقيح النتائج
  1. 821
  2. 822
  3. 823
  4. 824
  5. 825
  6. 826
  7. 827
  8. 828
  9. 829
  10. 830
  11. 831

    Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

    منشور في 2025
    "…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"
  12. 832

    Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

    منشور في 2025
    "…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"
  13. 833

    Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

    منشور في 2025
    "…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"
  14. 834
  15. 835

    Downregulation of <i>TcPiezo1</i> expression decreases Ca<sup>2+</sup> entry in <i>T. cruzi.</i> حسب Guozhong Huang (673424)

    منشور في 2025
    "…(B) Downregulation of <i>TcPiezo1</i> expression showed a significant decrease of intracellular Ca<sup>2+</sup> (+Tet). …"
  16. 836
  17. 837
  18. 838
  19. 839
  20. 840