Global and national estimates of disability-adjusted life years (DALYs) due to <i>Klebsiella pneumoniae</i>-associated lower respiratory infections in 1990 and 2021. by Juanjuan Li (399633)

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DALYs rate and SDI across all regions between1990 and 2021 (a). DALYs rate across all countries in 2021 by SDI (b). DALYs disability-adjusted life years, SDI socio-demographic inde... by Juanjuan Li (399633)

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The number and ASR of deaths for <i>Klebsiella pneumoniae</i>-related LRI burden in 1990 and 2021, and its trends from 1990 to 2021. by Juanjuan Li (399633)

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The global disease burden of <i><i>Klebsiella pneumoniae</i></i> associated LRI for both sexes in 204 countries and territories. (a) The number of deaths in 2021; (b) The EAPC of d... by Juanjuan Li (399633)

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The number and ASR of DALYs for <i>Klebsiella pneumoniae</i>-related LRI burden in 1990 and 2021, and its trends from 1990 to 2021. by Juanjuan Li (399633)

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Table 1_Subjective spatial orientation discomfort is associated with decreased real-world spatial performance and lower cognitive function.docx by Johannes Gerb (10287758)

Raw data of Fig 2-Fig 13 in this study. by Wen Wen Zheng (17721404)

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DAS and Y27632 down-regulated the mRNA and protein expression of CK8-RhoA/ROCK1 pathway and up-regulated TJs expression in intestines of infected mice. by Wen Wen Zheng (17721404)

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qPCR analysis of CK8 knockdown affecting Clauding-1 mRNA expression. by Wen Wen Zheng (17721404)

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Molecular-docking simulation of the TsSPc–CK8 complex in Caco-2 cells. by Wen Wen Zheng (17721404)

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CK8 knockdown and ROCK1 inhibitor abolished rTsSPc-reduced TJs expression in Caco-2 monolayers by IFA. by Wen Wen Zheng (17721404)

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PAS staining of intestinal sections from <i>T. spiralis</i>-infected mice pretreated with DAS and Y27632. by Wen Wen Zheng (17721404)

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qPCR and Western blotting of CK8 knockdown blocking the rTsSPc-activated pathway and -reduced TJs expression. by Wen Wen Zheng (17721404)

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IFA, GST pull-down and Co-IP assay of specific binding between rTsSPc and CK8. by Wen Wen Zheng (17721404)

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Transcription and expression levels of CK8 in Caco-2 cells after CK8 gene was knocked down. by Wen Wen Zheng (17721404)

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qPCR and Western blotting of activation of CK8 receptor and RhoA/ROCK1 pathway proteins in Caco-2 cells treated with rTsSPc and IIL ES antigens. by Wen Wen Zheng (17721404)

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HE staining showed that DAS and Y27632 alleviated intestinal inflammation in <i>T. spiralis</i>-infected mice. by Wen Wen Zheng (17721404)

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The ROCK1 pathway inhibitor Y27632 prevented rTsSPc from activating the ROCK1 pathway and reducing TJs expression. by Wen Wen Zheng (17721404)

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qPCR (A-D) and ELISA (E-H) detection of inflammatory cytokines in intestine of <i>T. spiralis</i>-infected mice. by Wen Wen Zheng (17721404)

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Presentation 1_Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.pptx by Juan Chen (61123)

“…</p>Conclusion<p>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA Bdnf-as.…”