Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes. by Michelle So (400874)

“…Beta2 score, derived from fasting glucose, C-peptide, HbA1c and insulin dose at 12 weeks, was optimal for predicting QRS>0 following one year of treatment with baricitinib and the other immunotherapies (areas under receiver-operator curve 0.864 and 0.765 respectively). A 6.2% decrease in Beta2 score at week 12 predicted significant improvement in HbA1c (-0.6% or -6 mmol/mol) and insulin use (-0.26 units/kg/day) in combined data from the rituximab, abatacept and anti-thymocyte globulin trials.…”

Image 1_Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectives... by Haixiao Jiang (12013904)

“…</p>Results<p>Our findings showed a significant decrease in the diversity and even distribution of microorganisms in the HE group when compared to the HC and NE groups. …”

Model of the consequences of Ctu1 deficiency in zebrafish, figured by Figdraw. by Yangziwei Yu (20460661)

“…Inactivation of the CTU complex leads to a thermosensitive decrease with aberrant development in the nematode and fission yeast [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0315854#pone.0315854.ref015" target="_blank">15</a>]. …”

DataSheet1_OsPDIL1-5: dual role in promoting growth and development while modulating drought stress tolerance in rice (Oryza sativa L.).docx by Jilin Chen (19847928)

“…This discovery highlights the importance of GDDT as a pleiotropic gene with significant implications for both plant growth and drought resistance. …”

Table 4_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…Ten and five of these upregulated genes were classified into two significantly enriched KEGG pathways: cell cycle and progesterone-mediated oocyte maturation (q-value <0.05), respectively. …”

Table 4_Is takeout culture associated with rising colorectal cancer in young Chinese adults? An ecological analysis of GBD and CHNS data.xlsx by Ling Yao (16961)

“…Among non-neoplastic digestive diseases, inflammatory bowel disease showed the most pronounced decrease. In contrast, the burden of colorectal cancer has increased annually across all age groups. …”

Table 2_Global patterns and health impact of unintentional injuries among children and adolescents, 1990–2021.docx by Wei Wei (21173)

“…Among the five socio-demographic index (SDI) regions, the low-middle SDI region exhibited the most significant decrease in injury incidence. Regionally, from 1990 to 2021, the Caribbean experienced the largest relative increase in injury incidence (EAPC 0.25, 95% CI: −0.60 to 1.11). …”

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Table 1_Association between eating behavior patterns and the therapeutic efficacy of GLP-1 receptor agonists in individuals with type 2 diabetes: a multicenter prospective observat... by Yuya Koide (22261300)

“…</p>Results<p>GLP-1RA therapy significantly reduced HbA1c, body weight, and body fat percentage at 12 months. …”

Table 3_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…Ten and five of these upregulated genes were classified into two significantly enriched KEGG pathways: cell cycle and progesterone-mediated oocyte maturation (q-value <0.05), respectively. …”

Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration by Xinyi Zhang (36040)

“…Multifunctional composite wound dressings hold significant promise for diabetic wound healing. However, the detrimental role of the advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding wound repair remains underexplored. …”

Table 4_Analysis of global, regional, and national burdens of neonatal encephalopathy from 1990 to 2021: insights from the Global Burden of Disease Study 2021.doc by Shujun Tan (20011518)

“…</p>Results<p>The global burden of NE has significantly declined over the past three decades. Between 1990 and 2021, the global ASIR decreased from 20.22 to 17.16, while the number of cases fell from 1,295,891.1 to 1,061,448.15, reflecting an 18.09% reduction. …”

Electrophysiological characterization of <i>C. elegans</i> body-wall muscles. by Xuexing Du (20624042)

“…The top section of each column illustrates the currents in different mutants, while the bottom section depicts the ionic currents obtained by subtracting the corresponding mutant currents from the total wild type (WT) currents, highlighting a significant decrease in <i>shk-1(lf)</i> and a slight reduction in <i>slo-2(lf)</i> mutants. …”

Presentation 1_Burden of falls in China, 1992–2021 and projections to 2030: a systematic analysis for the global burden of disease study 2021.pdf by Liang Sui (20912441)

“…DALYs and years of life lost (YLLs) rates generally decreased, with intervals of stabilization and minor increases, while years lived with disability (YLDs) showed significant fluctuations. …”

Data Sheet 1_Characterization of vaginal microbiota across female reproductive phases.zip by Qingzhi Zhai (21265412)

“…</p>Results<p>Microbial communities show significant variations across the different reproductive phases. …”

Table 4_Global patterns and health impact of unintentional injuries among children and adolescents, 1990–2021.docx by Wei Wei (21173)

“…Among the five socio-demographic index (SDI) regions, the low-middle SDI region exhibited the most significant decrease in injury incidence. Regionally, from 1990 to 2021, the Caribbean experienced the largest relative increase in injury incidence (EAPC 0.25, 95% CI: −0.60 to 1.11). …”

Image3_Fine-root and leaf acquisitive traits decoupled from chloride accumulation in reflecting the differential salinity tolerance among Prunus hybrids.jpeg by Shuangxi Zhou (199545)

“…No hybrid showed concurrent significant decrease of SLA and specific root surface area (SRA) under salt treatment. …”

Image 1_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.pdf by Ana Virseda-Berdices (9638081)

“…Ten and five of these upregulated genes were classified into two significantly enriched KEGG pathways: cell cycle and progesterone-mediated oocyte maturation (q-value <0.05), respectively. …”

Table 3_Analysis of global, regional, and national burdens of neonatal encephalopathy from 1990 to 2021: insights from the Global Burden of Disease Study 2021.doc by Shujun Tan (20011518)

“…</p>Results<p>The global burden of NE has significantly declined over the past three decades. Between 1990 and 2021, the global ASIR decreased from 20.22 to 17.16, while the number of cases fell from 1,295,891.1 to 1,061,448.15, reflecting an 18.09% reduction. …”

Image 2_One-year post lockdown trajectories of mental health and impact of COVID-19 lockdown-related factors.jpeg by Mathilde Mongeau (20864315)

“…</p>Results<p>Our analysis revealed a significant decrease in the proportion of individuals experiencing poor mental health (elevated GAD-7 or PHQ-9 > 4) from lockdown period to 1 month and 6 months post-lockdown. …”