Safety and Immunomodulatory Effects of Three Probiotic Strains Isolated from the Feces of Breast-Fed Infants in Healthy Adults: SETOPROB Study by Julio Plaza-Diaz (477264)

“…Administration of <i>B. breve</i> CNCM I-4035 resulted in a significant increase in fecal secretory IgA content. …”

Table3_Role of symbiotic microbiota dysbiosis in the progression of chronic kidney disease accompanied with vascular calcification.XLSX by Mengying Sun (4744332)

“…Vascular calcification (VC) represents a significant risk factor for cardiovascular events in individuals with CKD. …”

Data_Sheet_1_Nasal High Flow at 25 L/min or Expiratory Resistive Load Do Not Improve Regional Lung Function in Patients With COPD: A Functional CT Imaging Study.docx by Julien G. Cohen (10951629)

“…</p>Results<p>ΔHU was: BL (median, IQR): 85 (67.2, 102.8); NHF: 90.7 (57.4, 97.6); ERL: 74.6 (46.4, 89.6) HU (p = 0.531); and LD: 27.8 (22.3, 39.3); 17.6 (15.4, 27.9); and 20.4 (16.6, 23.6) mm (p = 0.120) in the 3 conditions, respectively. No significant difference in trapping was observed. Respiratory rate significantly decreased with both treatments [BL: 17.3 (16.4, 18.9); NHF: 13.7; ERL: 11.4 (9.6, 13.2) bpm; and p < 0.001].…”

Data_Sheet_2_Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice.pdf by Jie Gao (10266)

“…There was a significant correlation between differential urinary metabolites and differential gut microbiota.…”

Table_8_Global, regional, and national burden of digestive diseases: findings from the global burden of disease study 2019.docx by Fang Wang (105926)

“…The estimated annual percentage changes were significantly associated with the baseline ASIR, ASDR, and ASDALYs for the overall digestive diseases, and the negative correlations between ASDR, ASDALYs, and human development index both in 1990 (R = −0.68, R = −0.69) and 2019 (R = −0.71, R = −0.73) were noticed.…”

Table4_α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis.XLSX by Tian-Tian Jiang (11857058)

“…<p>A previously validated anti-rheumatic compound α-mangostin (MAN) shows significant metabolism regulatory effects. The current study aimed to clarify whether this property contributed to its inhibition on synovial angiogenesis. …”

Transcriptomics of Desiccation Tolerance in the Streptophyte Green Alga <i>Klebsormidium</i> Reveal a Land Plant-Like Defense Reaction by Andreas Holzinger (153856)

“…<div><p>Background</p><p>Water loss has significant effects on physiological performance and survival rates of algae. …”

Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study by Patricia Hafner (479961)

“…These changes were associated with improved clinical scores. …”

Image_1_Effects of Intranasal Oxytocin on Pup Deprivation-Evoked Aberrant Maternal Behavior and Hypogalactia in Rat Dams and the Underlying Mechanisms.jpg by Xiao Yu Liu (1264464)

“…IAO partially improved these changes in rat dams, which was not as significant as IAO effects on control dams. …”

Table 3_A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impair... by Ulrike Gimsa (9730208)

“…<p>In both humans and mice, obesity is often associated with peripheral and central inflammation, which can lead to diabetes, dysregulation of the stress response, changes in affective behavior, and memory impairment. …”

Image_7_Smp38 MAP Kinase Regulation in Schistosoma mansoni: Roles in Survival, Oviposition, and Protection Against Oxidative Stress.TIF by Lívia das Graças Amaral Avelar (6257927)

“…We propose to assess the role of Smp38 MAPK signaling pathway in Schistosoma mansoni development and protection against oxidative stress, parasite survival, and also to elucidate which target genes have their expression regulated by Smp38 MAPK. After a significant reduction of up to 84% in the transcription level by Smp38 MAPK gene knockdown, no visible phenotypic changes were reported in schistosomula in culture. …”

Image_5_Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial.jpeg by Asmaa M. N. Fatani (16474596)

“…</p>Results<p>Intake of PHF contributed an additional 9 g/d of dietary fiber to the subjects’ diet due to compliance. No significant changes from baseline were observed in serum PCS, IS, PAG, or TMAO, or for the relative quantification of Akkermansia muciniphila, Faecalibacterium prausnitzii, Bifidobacterium, or Roseburia, taxa considered health-enhancing. …”

Image_2_Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients.tif by Wenwu Sun (9936699)

“…Even though there seems a declining trend in mortality, no significant association is found after adjustment for potential confounders. …”

Image3_The 5HT4R agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in PrP-SCA7-92Q transgenic mice.JPEG by Yongqiang Liu (651861)

“…</p>Results<p>Analysis of SCA7 Tg mice showed tissue damage and alterations, mucosal abnormalities, and ulcers in the distal small intestine and proximal colon. Morphological changes were associated with significant neuronal loss, as shown by decreased staining of pan-neuronal markers, and with accumulation of ataxin-7-positive inclusions in cholinergic neurons. …”

Table_4_Clostridium butyricum potentially improves inflammation and immunity through alteration of the microbiota and metabolism of gastric cancer patients after gastrectomy.xlsx by Wenjie Cao (780652)

“…In addition, the use of the C. butyricum greatly enriched the relative abundance of beneficial bacteria Bacteroides, Faecalibacterium and Gemmiger, while the abundance of pathogenic Streptococcus, Desulfovibrio and Actinomyces were markedly decreased at genus level. We also observed significant up-regulation of SCFAs, including acetic acid, propionic acid, butyric acid and isobutyric acid, after C. butyricum administration in patients receiving gastrectomy.…”

Image2_The 5HT4R agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in PrP-SCA7-92Q transgenic mice.JPEG by Yongqiang Liu (651861)

“…</p>Results<p>Analysis of SCA7 Tg mice showed tissue damage and alterations, mucosal abnormalities, and ulcers in the distal small intestine and proximal colon. Morphological changes were associated with significant neuronal loss, as shown by decreased staining of pan-neuronal markers, and with accumulation of ataxin-7-positive inclusions in cholinergic neurons. …”

Data_Sheet_1_Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis.docx by Bartosz Pilecki (3091188)

“…SP-D deficiency influenced local pro-inflammatory cytokine levels, with increased CCL3 and interleukin-6 but decreased CXCL1. Furthermore, CS exposure caused significant upregulation of pro-inflammatory ceramides and related ceramide synthase gene transcripts in SP-D-deficient mice compared to wildtype littermates. …”

Image_10_Smp38 MAP Kinase Regulation in Schistosoma mansoni: Roles in Survival, Oviposition, and Protection Against Oxidative Stress.TIF by Lívia das Graças Amaral Avelar (6257927)

“…We propose to assess the role of Smp38 MAPK signaling pathway in Schistosoma mansoni development and protection against oxidative stress, parasite survival, and also to elucidate which target genes have their expression regulated by Smp38 MAPK. After a significant reduction of up to 84% in the transcription level by Smp38 MAPK gene knockdown, no visible phenotypic changes were reported in schistosomula in culture. …”

Image_4_Smp38 MAP Kinase Regulation in Schistosoma mansoni: Roles in Survival, Oviposition, and Protection Against Oxidative Stress.TIF by Lívia das Graças Amaral Avelar (6257927)

“…We propose to assess the role of Smp38 MAPK signaling pathway in Schistosoma mansoni development and protection against oxidative stress, parasite survival, and also to elucidate which target genes have their expression regulated by Smp38 MAPK. After a significant reduction of up to 84% in the transcription level by Smp38 MAPK gene knockdown, no visible phenotypic changes were reported in schistosomula in culture. …”

Table4_Role of symbiotic microbiota dysbiosis in the progression of chronic kidney disease accompanied with vascular calcification.XLSX by Mengying Sun (4744332)

“…Vascular calcification (VC) represents a significant risk factor for cardiovascular events in individuals with CKD. …”