Intratumoral FoxP3⁺Helios⁺ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer حسب Azharuddin Sajid Syed Khaja (19720114)

"…Levels of CD4⁺FoxP3⁺Helios⁺ Tregs were significantly increased in the TME. Furthermore, we observed increased levels of PD-1/CTLA-4 and PD-1/CD39 co-expressing cells within FoxP3⁺Helios⁺ and FoxP3⁺Helios⁻ Treg subsets, indicative of their potent immunosuppressive potential. …"

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

"…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …"

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans حسب Kirti S. Prabhu (4246144)

"…We also found that BTZ exerted its antitumor effects by generating reactive oxygen species (ROS), as blocking ROS production significantly reduced BTZ-induced apoptotic cell death. …"

The anticancer effect of β-2 himachalen-6-ol from Lebanese wild carrot on human acute myeloid leukemia cells. (c2016) حسب Boulos, Joelle C.

"…Cell cycle analysis using flow cytometry revealed an increase in the sub-G1 population. …"
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Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound حسب Ben-Daya, Mohamed

"…HA conjugation to the liposomes resulted in a significant increase in calcein uptake by the breast cancer cell line MDA-MB-231 known for its CD44 (HA receptor) overexpression, while such an effect was not recorded with NIH-3T3, an embryonic mouse fibroblast, with low levels of CD44 expression. …"
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... حسب Abou-Ghazal, Mohamed

"…Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-β, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …"
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Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…Furthermore, confocal microscopy analysis of BODIPY-stained untreated, steatotic, and Ex-4-treated steatotic cells showed that Ex-4 significantly decreases the number of lipid droplets. …"

STARD 13 in prostate cancer. (c2018) حسب Saab, Sahar S.

"…Knocking down StarD13 by siRNA led to an increase in cell proliferation and adhesion yet a decrease in cell motility and cell speed in prostate cancer. …"
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Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response حسب Majdalawieh, Amin

"…The secretion of key pro-inflammatory mediators (IL-6, TNFα, and nitric oxide) by primary macrophages was significantly inhibited by Sesamum indicum. Moreover, Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor cells. …"
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Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma حسب El Soussi, Sarra

"…The protein expression of Sox-2, Oct-4, FABP5 and HMGA1 was significantly reduced whereas cleaved PARP1 and caspase-3 and p-H2AX was increased 48 h after drug treatment in the MYCN-amplified IMR-32 cell line. …"
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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…These results reiterate the decisive role of 5-Aza-CdR in lung cancer treatment since it induces the epigenetic regulation of NY-ESO-1 antigen, inhibits cell proliferation, increases apoptosis, and decreases invasiveness.…"

Characterization of the Urinary Metagenome and Virome in Healthy Children حسب Eman Wehedy (13275305)

The Paget's disease of bone risk gene <i>PML</i> is a negative regulator of osteoclast differentiation and bone resorption حسب Sachin Wani (11704868)

"…The differentiation, survival and resorptive activity of osteoclasts prepared from Pml−/− mice was increased compared with wild type. Furthermore, the inhibitory effect of IFN-γ on osteoclast formation from Pml−/− was significantly blunted compared with wild type. …"

Genotypic and phenotypic characterization of candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin. (c2018) حسب Toutounji, Maggie Nazih

"…Our results demonstrate an inverse correlation between resistance and virulence whereby resistance is due to thickening of the cell wall preventing the cell from gaining virulence attributes, while a more susceptible cell wall increases susceptibility to drugs but allows increased virulence.…"
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Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (<i>Dicentrarchus Labrax</i>) حسب Albandari Bin-Ammar (16381128)

"…A noticeable decrease (P<0.05) in malondialdehyde (MDA) and considerable upregulation of hepatic insulin-like growth factor 1 (IGF1) and interleukin-1beta (IL-1β) mRNA levels were found in CURNPs-supplemented fish in a dose-dependent manner. …"

Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla حسب Parul Singh (191877)

Comprehensive analysis of circulating miRNA expression profiles in insulin resistance and type 2 diabetes in Qatari population حسب Khaoula Errafii (10914446)

Designing a Flexible and Reconfigurable Manufacturing System Considering a Circular Shaped Layout حسب AlDuaij, Awrad Khalid

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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien... حسب Shayista Akbar (14442117)

Hydrogen bonding: a mechanism for tuning electronic and optical properties of hybrid organic–inorganic frameworks حسب Fedwa El-Mellouhi (2011099)