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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
Published 2025“…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …”
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The Determinants of Cryptocurrency Adoption: An Integrated Framework for the UAE
Published 2025“…To address this gap, the research integrates the Uncertainty Framework, Perceived Risk Theory, and UTAUT2 to develop a holistic model examining how uncertainty, perceived risk, and technology acceptance shape consumer behaviour. …”
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The Integration of AI and ICT in the Learning Environment: Education Leaders’ Perception
Published 2021“…The current paper therefore, proposes the need for integration of AI and ICT into the learning environment at the current backdrop of a global pandemic to shape the forthcoming horizontal, teaching and learning paradigm that will prepare students for a competitive and increasingly pluralistic world.…”
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Male and Female Teacher Views and Opinions on Integration of SEN Students
Published 2018“…Lastly, different recommendations have been suggested in improving the current views and opinions of the teachers on the issue of integration. The recommendations include creating a comprehensive market awareness, a universal design for learning process, increasing funding in the inclusion process, focusing on specific areas of specialism and advocating for the need of having a gradual transition in the education system.…”
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Effect of technology integration in teaching quadratic functions .... (c2011)
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The Integration of AI Into Quality Management in Industries Like Automotive, Healthcare, and Defence
Published 2025“…The survey included ten closed-ended questions, while the interviews were guided by six open-ended prompts exploring the practical impact of AI integration in QM operations. The findings reveal that AI significantly enhances real-time monitoring, defect detection, and predictive maintenance, contributing to improved product quality and operational resilience. …”
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