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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
Published 2025“…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …”
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Religiosity & Work Dynamics: Understanding Links to Resilience & Productivity
Published 2025“…Three theoretical frameworks were relied on: Job Demands-Resources (JD-R) model, Conservation of Resources (COR) theory, and Attachment Theory; the study conceptualizes intrinsic religiosity as a personal resource that enhances coping and performance. Statistical analyses — including correlations, linear regressions, and moderator testing — revealed that intrinsic religiosity significantly predicts both resilience and productivity. …”
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Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain
Published 2018“…</p><p dir="ltr"><br></p><h3>Results</h3><p dir="ltr">The FTIR results revealed that in the lesioned gray matter the relative distribution of lipid, lipid acyl and protein contents decreased significantly. Also at this locus, there was a significant increase in aggregated protein as detected by high-levels Aβ1-42. …”
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Bio-oil from microalgae: Materials, production, technique, and future
Published 2023“…The most efficient route to bio-oil production can be identified by analysing both the biomass feedstock and the final product. …”
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Bio-oil from microalgae: Materials, production, technique, and future
Published 2023“…The most efficient route to bio-oil production can be identified by analysing both the biomass feedstock and the final product. …”
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Enhancing Tomato Yield in Hot Climates through QTL for Qatar’s Food Security
Published 2025“…<p dir="ltr">High-temperature stress is a major limiting factor affecting year-round tomato production in Qatar. In line with the Qatar National Vision 2030, which prioritizes self-sufficiency in domestic agricultural production, the development of elite tomato varieties adapted to local environmental conditions is essential. …”
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Exploring machine learning approaches for biohydrogen production through dark fermentation in wastewater
Published 2025“…Dark fermentation has emerged as a promising method for sustainable hydrogen production while simultaneously treating wastewater. …”
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The influence of religiously motivated consumer boycotts on brand image, loyalty and product judgment
Published 2014“…However, by and large, boycotting was found not to have any significant impact on product judgment.…”
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