PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer حسب Caroline Spasojevic (3619418)

"…PKD1 has been previously shown to be a prognostic factor in ERα+ tamoxifen-resistant breast tumors and PKD1 overexpression confers estrogen independence to ERα+ MCF7 cells. In the present study, our goal was to determine whether PKD1 is a prognostic factor and/or a relevant therapeutic target in breast cancer. …"

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death حسب Tohme, Sara

"…In this study, we showed for the first time that arginine deprivation using a recombinant human arginase induces ferroptosis, an autophagy-mediated type of cell death in AML cells. Acute Myeloid Leukemia (AML) poses significant challenges due to its unfavorable prognosis and limited treatment options, particularly in elderly patients. …"
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An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - Are your sorted cells getting SICS? حسب Gerald Pfister (17075275)

"…However, majority of available cell sorters are pressurized, droplet-based systems, which apply significant environmental pressure and shear stress to cells during sorting. …"

Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression حسب Reem Saleh (3513056)

"…Aberrant expression of immune checkpoints (ICs), including programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene 3 (LAG-3) and T cell immunoreceptor with Ig and ITIM domains (TIGIT), can create an immune-subversive environment, which helps tumor cells to evade immune destruction. …"

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy حسب Ajaz A. Bhat (12984701)

"…The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. …"

Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents حسب Sheema Hashem (14150961)

"…<p>Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. …"

Targeting the Folate Receptor: Effects of Conjugating Folic Acid to DOX Loaded Polymeric Micelles حسب Elkhodiry, Mohamed A.

"…Results show an 80% increase in the accumulation of the antineoplastic agent in the FR+ cell line, when compared to the FR- cell line, thus providing evidence that the efficacy of Pluronic micelles, as drug delivery vehicles, can be enhanced via folic acid targeting.…"
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Tumor-Infiltrating Lymphoid Cells in Colorectal Cancer Patients with Varying Disease Stages and Microsatellite Instability-High/Stable Tumors حسب Salman M. Toor (8854751)

"…We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4+ and CD4+CD8+ double positive T cells were higher, while CD8+ T cells and CD4−CD8− double negative T cells were significantly lower in CRC tumors. …"

p53 Inhibition in Pancreatic Progenitors Enhances the Differentiation of Human Pluripotent Stem Cells into Pancreatic β-Cells حسب Idil I. Aigha (14913774)

"…Further differentiation of MPCs treated with PFT-μ into pancreatic β-cells showed that PFT-μ treatment did not significantly change the number of C-Peptide+ cells; however, the number of C-PEP+ cells co-expressing glucagon (polyhormonal) was significantly reduced in the PFT-μ treated cells. …"

Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers حسب Husseini, Ghaleb

"…Such an association constant indicates that at the concentrations of FA used in targeted drug delivery systems, a significant concentration of Dox exists as FA-Dox complexes with a quenched fluorescence. …"
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Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity حسب Mohamed Abu-Farha (18535590)

"…Elucidating the molecular mechanisms underlying these chronic conditions is of relevant importance as it might lead to the identification of novel anti-obesity targets. The purpose of the current study is to investigate differentially expressed proteins between lean and obese subjects through a shot-gun quantitative proteomics approach using peripheral blood mononuclear cells (PBMCs) extracts as well as potential modulation of those proteins by physical exercise. …"

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…We found a significant increase in the levels of CD4⁺FoxP3⁺Helios⁺ T cells, which represent potentially highly immunosuppressive Tregs, in the CRC TME. …"

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... حسب Masri, Oussama Samer

"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
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Beyond genetics: Exploring the role of epigenetic alterations in breast cancer حسب Kirti S. Prabhu (4246144)

"…Central to the progression of breast cancer are epigenetic aberrations, which significantly contribute to drug resistance and the emergence of cancer stem cell traits. …"

Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment حسب Nada Aakel (18877111)

"…These vesicles activate oncogenic pathways and can serve as biomarkers or therapeutic targets due to their role in disease modulation.</p><h3>Conclusion</h3><p dir="ltr">Exosomes play a pivotal role in solid cancer progression and offer significant potential in advancing our understanding of tumor biology. …"

Mutational landscape of aggressive cutaneous squamous cell carcinoma حسب Saade, Rami E.

"…Experimental Design: Whole exome sequencing was performed on 39 cases of aggressive cSCC to identify driver genes and novel therapeutic targets. Significantly mutated genes were identified with MutSig or complementary methods developed to specifically identify candidate tumor suppressors based upon their inactivating mutation bias. …"
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Myeloid Cells in Circulation and Tumor Microenvironment of Colorectal Cancer Patients with Early and Advanced Disease Stages حسب Salman M. Toor (8854751)

"…We found high levels of granulocytic myeloid cells (GMCs) in whole blood, but their levels were significantly lower in PBMCs. …"

Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabri... حسب Abdul Q. Khan (14153247)

"…Considering the crucial role of metabolic reprogramming in cancer‐cell growth and proliferation, target identification and the development of novel and multi‐targeting agents are imperative. …"

Encapsulation and Release of Calcein from Herceptin-conjugated eLiposomes حسب Zafar, Mah Noor

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Myeloid cells in circulation and tumor microenvironment of breast cancer patients حسب Salman M. Toor (8854751)

"…These findings are important for developing therapeutic modalities to target mechanisms employed by immunosuppressive cells that generate an immune-permissive environment for the progression of cancer.…"