STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration حسب Ayat S. Hammad (9592374)

"…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …"

Outcomes of POCUS‐Guided Peripheral Intravenous Access in Difficult Venous Access Patients: A Systematic Review and Meta‐Analysis حسب Hany A. Zaki (17337673)

"…A systematic review of 15 studies with 1485 patients, sourced from five databases, including PubMed, Cochrane Library, MEDLINE, Web of Science, and Google Scholar, showed POCUS significantly improved success rates (OR: 4.25), first‐attempt success (OR: 5.31), reduced attempts (MD: −0.83), and decreased procedure time (MD: −9.75 min). …"

Pattern of Postoperative Mortality After Esophageal Cancer Resection According to Center Volume حسب Markar, Sheraz

"…Results The 30-day and in-hospital POM rates were 5.0 and 7.3 %, respectively. Pulmonary complications were the most common, affecting 38.1 % of patients, followed by surgical site infection (15.5 %), cardiovascular complications (11.2 %), and anastomotic leak (10.2 %). …"
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Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies حسب Qiman Gao (12107281)

"…Pilot RCTs revealed that high-pressure NFLJI caused a high risk of discomfort (60%) and paresthesia (20%); meanwhile, low-pressure NFLJI was less likely to cause complications (0%). The preliminary success rates of MINB from cadavers using NFLJIs and needles were 83.3% and 87.5%. …"

Fixing a heart valve حسب Nature Research (16552612)

"…All of these factors significantly increase the rate of complications following valve replacement, so valve repair is a more viable option in these parts of the world. …"

Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review حسب Arwa Saed Aldien (17302849)

"…<p dir="ltr">Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates of mortality. …"

Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis حسب Maria K. Smatti (4675852)

"…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations.</p><h3>Conclusion</h3><p dir="ltr">Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …"

The Role of Levosimendan in Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest حسب Rasha, Kaddoura

"…There was no difference between the groups in terms of survival to decannulation (27.8% vs 26.1%), survival to hospital discharge (27.8% vs 24.6%), length of intensive care unit stay (19.1 vs 18.2 days), length of hospital stay (51.1 days vs 53.4 days), or complications rates (eg, infection, bleeding, and arrhythmias). …"
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Perinatal factors impacting echocardiographic left ventricular measurement in small for gestational age infants: a prospective cohort study حسب Ibrahim Elmakaty (14614270)

"…<h2>Introduction</h2><p dir="ltr">Infants born small for gestational age (SGA) have an increased risk of developing various cardiovascular complications. While many influencing factors can be adjusted or adapt over time, congenital factors also have a significant role. …"

Linburg–Comstock variation and syndrome. A meta-analysis حسب Yammine, Kaissar

"…Methods A systematic literature search identified 14 studies, including 4132 forearms/hands, which met the inclusion criteria. Results While no significant difference was found for laterality, we found significantly higher Linburg–Comstock variation rate in females compared to males. …"
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The Role of Levosimendan in Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest حسب Rasha Kaddoura (12506936)

"…There was no difference between the groups in terms of survival to decannulation (27.8% vs 26.1%), survival to hospital discharge (27.8% vs 24.6%), length of <u>intensive care unit</u> stay (19.1 vs 18.2 days), length of hospital stay (51.1 days vs 53.4 days), or complications rates (eg, infection, <u>bleeding</u>, and arrhythmias). …"

Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats حسب Maisa Siddiq Abduh (16381125)

"…Furthermore, significant downregulation of IL1-β, TNF-α, TGF-β, and Caspas-3 genes, as well as significant upregulation of Bcl-2 and IL-10 expression were detected. …"

Automated Detection of Colorectal Polyp Utilizing Deep Learning Methods With Explainable AI حسب Md. Faysal Ahamed (21842396)

"…These polyps cause severe conditions in the colon or rectum, presenting a significant diagnostic challenge. Traditional manual detection through medical imaging is not only bulky and prone to errors but also incurs substantial costs, requiring expert endoscopist. …"

Optimizing outcome reporting after robotic flexible ureteroscopy for management of renal calculi: Introducing the concept of tetrafecta حسب Morshed Salah (17824244)

"…<p dir="ltr">Robotic flexible ureteroscopy (RFURS) has shown encouraging results in terms of stone free rate (SFR) and better ergonomics compared to conventional FURS. …"

''Effectiveness of Non-invasive Positive Pressure Ventilation in ELBW Infants: A Comparison of Successful and Failed Outcomes'' حسب Ratheesh Paramban (17046388)

"…Chest X-ray findings of severe RDS were significantly lower in the NIPPV-success group (2.5% vs 28.6%). …"

Orofacial Clefts حسب El Baba, Nada

"…Through whole genome sequencing, we identified three variant genes, ARHGEF18, CUL7, and EPDR1, that we could link to the cleft phenotype. …"
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... حسب Mohamed Yassin (4166515)

"…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …"

Risk Factors of Difficult Intubation in Patients with Severe Obesity Undergoing Bariatric Surgery: A Retrospective Cohort Study حسب Ayten Saracoglu (8075222)

"…</p><h3>Results</h3><p dir="ltr">None of the patients experienced any complications of interest. Video laryngoscope was used in 85 patients (3.5%), first-attempt intubation success rate was 95.4%, with more than one attempt required in 4.6% of cases. …"

Quality of diabetes care in patients with schizophrenia: a case-control study in Qatar حسب Mustafa Abdul Karim (14152431)

"…Furthermore, the lifespan of people with schizophrenia is shortened by approximately 15 years, partly due to long-term microvascular and macrovascular complications. High quality diabetes care can significantly reduce morbidity and mortality. …"

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response حسب Noura Al-Zeheimi (5177066)

"…From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor <i>SNAI1</i> before and after NAC were significantly different. …"