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    Single Amine or Guanidine Modification on Norvancomycin and Vancomycin to Overcome Multidrug-Resistance through Augmented Lipid II Binding and Increased Membrane Activity by Xiaolei Bian (20136470)

    Published 2024
    “…Many derivatives revitalized the activity in vitro, exhibiting a 4–128-fold or 2–16-fold enhancement against the acquired or intrinsic resistance with lower toxicity. Significantly, the optimal compound <b>4g</b> demonstrated greater pharmacokinetic and pharmacodynamic profiles. …”
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