<b>Triptolide alleviates </b><b>cognitive</b><b> impairment via </b><b>autophagy</b><b> and Akt/mTOR/p70S6K pathway in an APP/PS1 Alzheimer’s disease mouse model</b> حسب xinyao Qi (21686459)

"…Notably, TP treatment led to a reduction in hippocampal Aβ1-40 level, suggesting a decrease in Aβ neuropathology. …"

PRISMA flow chart of study selection. حسب Tong-jie Yang (20939652)

"…</p><p> Conclusion </p><p>(1) HU can effectively contribute to the evaluation of bone and soft tissue densities in the proximal femur, and reflect local stress changes. (2) In ONFH patients, bone density does not decrease in the necrotic area of the femoral head before collapse. …"

Image 2_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff حسب M. Firoz Mian (10013314)

"…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …"

Image 3_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff حسب M. Firoz Mian (10013314)

"…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …"

Image 5_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff حسب M. Firoz Mian (10013314)

"…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …"

Image 4_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff حسب M. Firoz Mian (10013314)

"…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …"

Data Sheet 1_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf حسب Sadia Hamera (22524803)

"…<p>Ethylene plays a critical role in plant development and stress adaptation, with its biosynthesis tightly regulated by the stability of 1-aminocyclopropane-1-carboxylic acid synthase (ACS) proteins. …"

Data Sheet 1_Age-period-cohort analysis of global, regional, and national trends in laryngeal Cancer among older adults, 1990–2021: insights from the 2021 global burden of disease... حسب Zhe Sun (328682)

"…Background<p>Laryngeal cancer poses a significant health burden among older adults, with varying incidence, mortality, and disability-adjusted life years (DALYs) across regions. …"

Data Sheet 1_Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway.docx حسب Hailiang Li (740080)

"…Meanwhile, NADPH+ production and G6PDH enzyme activity significantly decreased. Further study validated that metformin inhibited the cell growth of GBM cell lines through up-regulating PER2 and inhibited SIRT2/G6PD signaling pathway, enhancing radiotherapy(RT) sensitivity. …"

Supplementary file 1_Restoration of antibiotic associated diarrhea induced gut microbiota disorder by using Dictyophora indusiata water-insoluble polysaccharides in C57BL/6J mice.d... حسب Yong Lai (4104235)

"…Also, compared with the NR group, DIPY increasing the relative abundance of Parasutterella and Blautia, increasing the production of acetic acid (p < 0.001), and decreasing the levels of LPS, MCP-1, TNF-α, and IL-6 (p < 0.05) which attenuating inflammatory responses.…"

Image 1_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno... حسب Shao-jun Xu (11633956)

"…The dynamic mortality risk rate revealed a double peak in the high-risk patients (12 and 48 months) and a single peak in the low–risk patients (24 months) and middle-risk patients (12 months), which gradually decreased over time.…"

Image 1_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.tif حسب Zhenzhen Gu (21488168)

"…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …"

Table 1_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.xlsx حسب Zhenzhen Gu (21488168)

"…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …"

Data Sheet 1_Replacement of fish oil with Schizochytrium-derived monoglycerides enriched in docosahexaenoic acid on the growth performance, lipid composition, and intestinal microb... حسب Wei Huang (36889)

"…It was noted that the addition of DHA-MGs significantly decreased the abundance of potentially pathogenic bacteria, manifesting that DHA-MGs could readjust the intestinal microecological balance for intestinal health. …"

Data Sheet 2_Assessing the impact of moxibustion on colonic mucosal integrity and gut microbiota in a rat model of cerebral ischemic stroke: insights from the “brain-gut axis” theo... حسب Yi-Xia Ding (20792930)

"…Furthermore, the moxibustion group demonstrated decreased inflammatory cell infiltration in colonic tissues, increased expression of Occludin and ZO-1 proteins in colonic tissues (p < 0.05), enhanced gut microbiota structure, and a decreased Simpson index (p < 0.05).…"

Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx حسب Jikai He (11888466)

"…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…"

Overall program sustainability assessment results. حسب Amanda Marr Chung (21696743)

Table 1_NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patie... حسب Xiaohui Zhang (81778)

"…During the 12-month follow-up of induction therapy, NLR and PLR showed a decreasing trend. Both baseline NLR and SII were positively correlated with baseline UTP and serum creatinine (SCr) levels (r = 0.112-0.148, p< 0.05 for all). …"

Table 1_Distribution and environmental drivers of macrofaunal nematode communities across gradients of methane seepage at cold seeps on Hikurangi Margin (New Zealand) and potential... حسب Daniel Leduc (9191783)

"…However, a consistent spatial pattern in nematode abundance was observed within all the seep areas on the Hikurangi Margin: abundance was highest at or near the seep centre, decreased steeply away from the centre and was low in the periphery. …"

Supplementary file 1_Burden of hypertensive heart disease attributed to metabolic factors from 1990 to 2021 at global, regional, and national levels: an analysis of the global burd... حسب Bo Peng (273834)

"…</p>Results<p>In 2021, deaths and DALYs due to HSBP and high BMI significantly increased compared to 1990. However, the ASMR for HSBP-related HHD [EAPC: −0.68; 95% confidence interval (CI): −0.77 to −0.58] and ASDR (EAPC: −0.90; 95% CI: −0.99 to −0.80) showed a decreasing trend, while the ASMR for BMI-related HHD (EAPC: 0.33; 95% CI: 0.27–0.39) and ASDR (EAPC: 0.15; 95% CI: 0.10–0.21) exhibited an increasing trend. …"