Supplementary Material for: Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance حسب figshare admin karger (2628495)

"…Results: Analysis of the GSE196656 dataset revealed significant upregulation of TIMP4 in heart failure. …"

Image 1_BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.tif حسب Man Zhao (314232)

"…Furthermore, silencing BNIP3 leads to a significant reduction in mitochondrial damage and mtROS production. …"

Data Sheet 4_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf حسب Meizhi Liu (21898892)

"…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …"

Data Sheet 1_Thermophilic microbial agents promote the fermentation progression of spent mushroom compost and pig manure.docx حسب Hongbo Du (1270113)

"…Notably, the co-addition of thermophilic microbial agents and SMC reduced persistent ARGs by lg0.45–3.73, significantly decreased the abundances of HPB such as Bacteroides and Treponema, and reduced the enrichment of related metabolic pathways, greatly improving compost quality. …"

Table 1_Near-infrared prediction of total phosphorus in leaves content in korla fragrant pear with growth period specificity via spectral modeling.docx حسب Mingyang Yu (7456358)

"…Results The study showed that LTP content exhibited a significant differential distribution across different growing stage. …"

Data Sheet 1_Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database.docx حسب Peiyang Cao (10808613)

"…</p>Conclusion<p>While tolvaptan provides therapeutic benefits, it poses a risk of significant adverse reactions. Clinicians should closely monitor the occurrence of events related to hepatobiliary disorders, renal and urinary disorders, metabolic and nutritional disorders, as well as benign, malignant, and indeterminate tumors during its clinical use.…"

Data Sheet 1_Does chlorhexidine improve periodontal health and bacterial profiles in patients with special health care needs? A systematic review and meta-analysis.docx حسب Deepak Sharma (131639)

"…Gingival inflammation also decreased significantly across studies (mean difference = −0.214; 95% CI: −0.306 to −0.121; P < .001), with 0.2% CHX formulations demonstrating the most consistent improvement.…"

Table_1_Construction of a risk screening and visualization system for pulmonary nodule in physical examination population based on feature self-recognition machine learning model.X... حسب Fang Tian (360682)

"…</p>Results<p>Multivariable analysis identified older age, smoking or passive smoking, high psychological stress within the past year, occupational exposure (e.g., air pollution at the workplace), presence of chronic lung diseases, and elevated carcinoembryonic antigen levels as significant risk factors for pulmonary nodules. The feature self-recognition machine learning model further highlighted age, smoking or passive smoking, high psychological stress, occupational exposure, chronic lung diseases, family history of lung cancer, decreased albumin levels, and elevated carcinoembryonic antigen as key predictors for early pulmonary nodule risk, demonstrating superior performance.…"

Table 1_Clinical outcomes and psychosomatic correlates of integrative inpatient care based on Traditional Korean Medicine for acute neck and low back pain following traffic acciden... حسب Yohwan Kim (5482454)

"…Greater reductions in axial pain, as measured by Numeric Rating Scale scores, were significantly associated with decreases in scores on the Beck Anxiety Inventory, Fatigue Severity Scale, Patient Health Questionnaire-9, and Insomnia Severity Index in regression analyses adjusted for clinical and demographic covariates. …"

Effects of task optimization on pareidolia representations in CNNs. حسب Pranjul Gupta (20623949)

"…Conversely, in CNNs lacking object categorization training (Panels B, C), this similarity was weak, only reaching significance at early layers, and decreased across layers. …"

Table 3_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.doc حسب Meizhi Liu (21898892)

"…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …"

DataSheet2_Screening of active components of melastoma dodecandrum lour. against diabetic osteoporosis using cell membrane chromatography-mass spectrometry.pdf حسب Xiaoqin Zhang (517854)

"…Cell experiments further validated the activity of the characteristic component isovitexin.</p>Results<p>MD significantly improved cell viability in AGEs-damaged osteoblasts, enhanced ALP, SOD, CAT, and GPx activities, reduced MDA levels, increased OCN and RUNX2 protein expression, and decreased TNF-α mRNA and RAGE protein expression. …"

Image 6_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.tiff حسب Tien Le (634791)

"…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…"

Table 3_Apoptosis and autophagy promote Babesia microti infection in tick midguts: insights from transcriptomic and functional RNAi studies.docx حسب Songqin Chen (9625886)

"…Functional assays demonstrated that RNA interference (RNAi)-mediated knockdown of caspase-7, caspase-9, and ATG5 significantly reduced the burden of B. microti. Conversely, pharmacological induction of autophagy using rapamycin increased B. microti load, whereas inhibition with 3-methyladenine (3-MA) decreased B. microti load.…"

Data Sheet 2_Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels.pdf حسب Shuang Li (146392)

"…At the national level, ASRs consistently decreased with higher SDI.</p>Conclusion<p>This study highlights the substantial burden of NRLC at global, regional, and national levels. …"

Supplementary Material for: Dorsal Column Spinal Cord Stimulation Attenuates Brain-Spine Connectivity through Locomotion and Visuospatial-Specific Area Activation in Progressive Fr... حسب Zemmar A. (11259339)

"…Introduction: Freezing of gait (FOG) is a clinical phenomenon with major life impairments and significant reduction in quality of life for affected patients. …"

Data Sheet 1_Divergent profiles of rhizosphere soil carbon and nitrogen cycling in Pinus massoniana provenances with different types of carbon storage.docx حسب Zichen Huang (6587885)

"…</p>Results<p>Our findings revealed a significant increase in the relative abundance of Acidobacteriota and Ascomycota by 23 and 61%, respectively, whereas Basidiomycota significantly decreased by 8% in the rhizosphere of P. massoniana provenances with high carbon storage compared with those with low carbon storage. …"

Supplementary file 1_Dynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms.docx حسب Safiya Al Yazeedi (22075034)

"…<p>Mechanical strain plays a significant role in lung pathophysiology. Current two-dimensional (2D) in vitro models fail to capture the lung's dynamic mechanical environment. …"

Table 2_Changes in symptom pattern in Meniere's disease by duration: the need for comprehensive management.docx حسب Ilmari Pyykkö (2855153)

"…The frequency and duration of vertigo attacks generally decreased over time, with attacks becoming shorter and less severe as the disease progressed. …"

Image2_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG حسب Jacob Raiten (20021262)

"…In vivo, these preconditioned MuSCs led to decreased infiltration of CD4⁺ and CD8⁺ T cells in implanted limb muscles of mouse models. …"