Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1‑OH···Nucleophile in Transition State Stabilization in Arabidopsis thaliana Cell-Wall Invertase 1 by Wijitra Jitonnom (22410515)

“…Here, quantum mechanical/molecular mechanical (QM/MM) free-energy simulations were carried out to clarify the origin of the observed decreased rates in Asp239Ala, Asp239Asn, and Asp239Phe in AtCWIN1 compared to the wild type and delineate the role of Asp239 in catalysis. …”

Effect of ibuprofen (IBU) on HIF-1α transcriptional activity and protein level. by Katarina Grossmannova (7543517)

“…(D) Detection of HIF-1 target proteins PDHK1 and LDHA in HCT116 and FaDu cells treated with IBU in hypoxia revealed decreased levels of all proteins under 1 mM IBU treatment. …”

FK506 significantly potentiates caspofungin activity against tolerant <i>C. tropicalis</i> strains, reversing tolerance phenotypes in both <i>in vitro</i> and <i>in vivo</i> models... by Yongqin Wu (272012)

“…(F) FK506 substantially decreases the fungal load in <i>G. mellonella</i> larvae infected with tolerant strains and treated with caspofungin. …”

Community consumption of J01 antibiotics at national and state levels expressed as DDD per 1000 inhabitants and per day (DID), Brazil, 2014−2020. by Tatiana de Jesus Nascimento Ferreira (21492903)

“…³Trend- indicates that the change in consumption (↑ increase or ↓ decrease) was statistically significant (p-value ≤ 0.05%). …”

Marginal epistasis tests identify single nucleotide polymorphisms (SNPs) that have epistatic interactions with others and are associated with the changes in viral copies. by Ke Li (106849)

Community consumption of systemic antibiotics, according to Therapeutic Subgroup ATC 3^rd level, expressed as DDD per 1000 inhabitants and per day (DID) and relative cons... by Tatiana de Jesus Nascimento Ferreira (21492903)

“…³ Indicates ↑ increase or ↓ decrease in consumption statistically significant (p-value ≤ 0.05%). …”

LPS treatment increases the expression of NF-κB-related inflammatory factors, hTERT and cell apoptosis in KGN cell and correlation between NF-κB-related inflammatory factors, TERT... by Haoxuan Xue (19949764)

Apoptosis is increased in the ovary of PCOS rats, and there is a correlation between NF-κB-related inflammatory factors, TERT and apoptosis factors. by Haoxuan Xue (19949764)

scRNA seq revealed the host immune transcriptomic signatures in individual myeloid cells during <i>C</i>. <i>auris</i> skin infection. by Abishek Balakumar (20189865)

Protective effect of SMND-309 against liver injury in acute liver injury model mice. by Yao Dong (3308124)

scRNA seq revealed the transcriptomic signatures in fibroblast and other non-immune cells during <i>C</i>. <i>auris</i> skin infection. by Abishek Balakumar (20189865)

Flow chart of the literature search. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

ATPase activity of Pns10 does not contribute to mitochondrial energy impairment or ROS accumulation in Sf9 cells. by Lianshun Zheng (22086585)

Funnel plot for scar thickness. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

Network plot for VSS score. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

Network plot for scar thickness. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

Funnel plot for VSS score. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

Characteristics of the included trials (n = 17). by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

Risk of bias graph. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”

Network plot for VAS score. by Xiaojuan Yang (794374)

“…The treatment ranking revealed that massage therapy demonstrated the most significant efficacy in reducing Vancouver Scar Scale score (surface under the cumulative ranking curve [SUCRA] = 89.0%), CO₂ laser therapy exhibited the highest efficacy in decreasing scar thickness (SUCRA = 96.8%), and extracorporeal shock wave therapy + routine treatment showed the most significant efficacy in reducing Visual Analogue Scale score (SUCRA = 58.6%).…”