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progress decrease » progressive decrease (Expand Search), problems decreased (Expand Search)
largest decrease » marked decrease (Expand Search)
larger decrease » marked decrease (Expand Search)
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2721
Image 2_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”
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2722
Data Sheet 1_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.pdf
Published 2024“…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …”
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2723
Image 14_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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2724
Table 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”
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2725
Image 12_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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2726
Image 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”
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2727
Image 4_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”
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2728
Table 1_Spontaneous neural activity alterations in medication-naïve primary blepharospasm: a resting-state functional magnetic resonance imaging study.docx
Published 2025“…</p>Results<p>Compared to healthy controls, medication-naïve patients with BSP exhibited significantly increased ALFF in the bilateral putamen and left premotor cortex and decreased ALFF in the bilateral thalamus (p < 0.05, threshold-free cluster enhancement with family-wise error correction for multiple comparisons). …”
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2729
Table1_Inhibition of CISD2 enhances sensitivity to doxorubicin in diffuse large B-cell lymphoma by regulating ferroptosis and ferritinophagy.docx
Published 2024“…Background<p>CDGSH iron-sulfur domain 2 (CISD2), an iron-sulfur protein with a [2Fe-2S] cluster, plays a pivotal role in the progression of various cancers, including Diffuse Large B-cell Lymphoma (DLBCL). …”
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2730
Data Sheet 1_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.docx
Published 2025“…</p>Results<p>Low-dose, but not high-dose, tofacitinib significantly increased survival and delayed weight loss. …”
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2731
Table 2_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.xlsx
Published 2025“…</p>Results<p>Low-dose, but not high-dose, tofacitinib significantly increased survival and delayed weight loss. …”
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2732
Image1_Inhibition of CISD2 enhances sensitivity to doxorubicin in diffuse large B-cell lymphoma by regulating ferroptosis and ferritinophagy.JPEG
Published 2024“…Background<p>CDGSH iron-sulfur domain 2 (CISD2), an iron-sulfur protein with a [2Fe-2S] cluster, plays a pivotal role in the progression of various cancers, including Diffuse Large B-cell Lymphoma (DLBCL). …”
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2733
Image2_Inhibition of CISD2 enhances sensitivity to doxorubicin in diffuse large B-cell lymphoma by regulating ferroptosis and ferritinophagy.JPEG
Published 2024“…Background<p>CDGSH iron-sulfur domain 2 (CISD2), an iron-sulfur protein with a [2Fe-2S] cluster, plays a pivotal role in the progression of various cancers, including Diffuse Large B-cell Lymphoma (DLBCL). …”
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2734
Table 1_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.xlsx
Published 2025“…</p>Results<p>Low-dose, but not high-dose, tofacitinib significantly increased survival and delayed weight loss. …”
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2735
Data Sheet 1_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx
Published 2025“…At 12 months, the median change in HbA1c levels did not differ significantly between groups. Regarding app usage, data entries decreased significantly from the first quarter to the second quarter but subsequently stabilised (p = 0.001). …”
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2736
Data Sheet 2_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx
Published 2025“…At 12 months, the median change in HbA1c levels did not differ significantly between groups. Regarding app usage, data entries decreased significantly from the first quarter to the second quarter but subsequently stabilised (p = 0.001). …”
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2737
Supplementary file 1_Bibliometrics-guided cyberpharmacology and transcriptomics for multidimensional analysis of the antihepatic fibrosis mechanism of kaempferol.docx
Published 2025“…Pharmacodynamic evaluations, including pathological section analyses, demonstrated that KA effectively mitigated the fibrotic process and decreased collagen deposition. Further corroborated by ELISA experiments, kaempferol exhibited pronounced anti-fibrotic effects, inhibited inflammatory responses, restored liver function indices, and ameliorated the progression of liver fibrosis. …”
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2738
Supplementary Material for: Downregulation of Signal Transducer and Activator of Transcription 4 (STAT4) contributes to impaired osteogenic differentiation of human bone marrow ste...
Published 2025“…Results: STAT4 expression progressively decreases during the in vitro expansion of hBMSCs, concomitant with the loss of osteogenic differentiation potential. …”
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2739
Data Sheet 3_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf
Published 2025“…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …”
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2740
Data Sheet 1_Case Report: Late diagnosis of McCune-Albright with severe kyphoscoliosis, acromegaly and tertiary hyperparathyroidism.pdf
Published 2025“…We present a case of a 40-year-old woman who was admitted to the Pulmonary Unit due to progressive pulmonary insufficiency secondary to severe scoliosis. …”