FLEXI interactions with RNA-binding proteins. by Jun Yao (9646)

“…RNA-binding sites: I, within introns corresponding to FLEXIs; SS-I and SS-E, bimodally enriched across the 5’- and 3’ splice sites in unspliced pre-mRNAs with the midpoints in the intron or flanking exon (SS-I and SS-E, respectively; Figs <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.g004" target="_blank">4A</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s011" target="_blank">S11</a>). mRNA levels, RBPs whose knockdown resulted in significant difference in mRNA levels (increased or decreased, DESeq2 |LFC|≥1, adjusted p≤0.05) from host gene of FLEXIs with a binding site for that RBP compared to those genes whose transcripts lacked a binding site for the same RBPs based on ENCODE RBP-knockdown datasets (p≤0.05 calculated by Fisher’s exact test; <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s013" target="_blank">S13 Fig</a>). …”

Expression of <i>SHH</i> in the FEZ after RCAS-virus infection to induce overexpression and knockdown of <i>PBX1</i> and <i>PBX3.</i> by Chan Hee Mok (11247669)

“…Statistical significance was determined at P-value < 0.05; *, P < 0.05; **, P < 0.01; ****, P < 0.0001; ns, not significant.…”

Table 1_Weissella confusa alleviates experimental colitis in mice by regulating inflammatory pathways and gut microbiota.xlsx by Huijing Tang (19133347)

“…</p>Results<p>Compared with DSS group, W. confusa Wc1982 significantly improved the disease phenotypes of colitis mice including decreased DAI and pathological score and reduced colon shortening, decreased colonic IL-17, IL-6, and TNF-α levels and serum lipopolysaccharide (p < 0.05), and downregulated the expression of key genes of IL-17 pathway (Lcn2, Mmp3, Mmp13, Ptgs2; p < 0.05). …”

Supplementary file 1_Weissella confusa alleviates experimental colitis in mice by regulating inflammatory pathways and gut microbiota.docx by Huijing Tang (19133347)

“…</p>Results<p>Compared with DSS group, W. confusa Wc1982 significantly improved the disease phenotypes of colitis mice including decreased DAI and pathological score and reduced colon shortening, decreased colonic IL-17, IL-6, and TNF-α levels and serum lipopolysaccharide (p < 0.05), and downregulated the expression of key genes of IL-17 pathway (Lcn2, Mmp3, Mmp13, Ptgs2; p < 0.05). …”

Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC by Xikai Luo (21520875)

“…Rs2071029T promoter activity was significantly higher than that of rs2071029C promoter (<i>p</i> = 0.014). …”

Effect of Gasdermin-D inhibition on expression of phenotypic transition markers in CER treated VSMCs during Vascular Calcification. by Razia Rashid Rahil (22772495)

“…(B) Summarized bar graph showed DIS significantly decreased calcium deposition in CER treated P_i-induced VSMCs. …”

Effect of NLRP3 inhibition on expression of phenotypic transition markers in CER treated VSMCs during Vascular Calcification. by Razia Rashid Rahil (22772495)

“…(B) Summarized bar graph showed MCC950 significantly decreased calcium deposition in CER treated P_i-induced VSMCs. …”

Image 2_Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.jpeg by Caressa Hui (19676509)

“…Introduction<p>Volumetric modulated arc therapy (VMAT) total body irradiation (TBI) allows for greater organ sparing with improved target coverage compared to 2D-TBI. …”

Image 1_Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.jpeg by Caressa Hui (19676509)

“…Introduction<p>Volumetric modulated arc therapy (VMAT) total body irradiation (TBI) allows for greater organ sparing with improved target coverage compared to 2D-TBI. …”

Raw Data. by Hongfei Liu (1396348)

“…COS supplementation significantly increased serum superoxide dismutase activity and jejunal mucosal glutathione peroxidase activity, and significantly decreased serum malondialdehyde level (<i><i>P</i></i> < 0.05). …”

DataSheet1_Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD.doc by Hyun-ju Lee (7550741)

“…Furthermore, erlotinib-treated 5xFAD mice exhibited significant downregulation of astrocyte activation, and treating PACs from 5xFAD mice with erlotinib markedly reduced cxcl10 (reactive astrocyte marker) and gbp2 (A1 astrocyte marker) mRNA levels and proinflammatory cytokine mRNA and protein levels. …”

Image 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf by Yicheng Zhang (790286)

“…Our results demonstrated that under T1–T3, the germination rate, α-amylase activity, and soluble sugar and protein contents were significantly increased after priming treatments. The contents of reactive oxygen species (i.e., O₂⁻ and H₂O₂) and malondialdehyde (MDA) were decreased, while the activities of enzymatic antioxidants (i.e., superoxide dismutase, peroxidase, and catalase) and the K⁺/Na⁺ ratio of rice were significantly increased after the above seed priming treatments. …”

Table 1_Prior Trichinella spiralis infection protects against Schistosoma mansoni induced hepatic fibrosis.docx by Asmaa M. El-kady (16502930)

“…Furthermore, pre- infection with T. spiralis markedly reduced S. mansoni- induced hepatic fibrosis, as evidenced by decreased collagen deposition, low expression of α-SMA, and significantly reduced levels of IL-17, IL-1B, IL-6, TGF-B, IL-23, and TNF-α compared to mice infected with S. mansoni only.…”

Table 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf by Yicheng Zhang (790286)

“…Our results demonstrated that under T1–T3, the germination rate, α-amylase activity, and soluble sugar and protein contents were significantly increased after priming treatments. The contents of reactive oxygen species (i.e., O₂⁻ and H₂O₂) and malondialdehyde (MDA) were decreased, while the activities of enzymatic antioxidants (i.e., superoxide dismutase, peroxidase, and catalase) and the K⁺/Na⁺ ratio of rice were significantly increased after the above seed priming treatments. …”

Table 4_Global, region and country burden of osteoarthritis at different sites in middle-aged and elderly populations from 1990 to 2021: a systematic analysis of the 2021 global bu... by Guoxin Huang (5775458)

“…From 1990 to 2021, the inequality in overall OA burden between countries had decreased. The absolute inequality gap for hand OA had narrowed the most significantly (45.3%), which followed by knee OA (11.9%), while the inequality gap for hip OA has slightly increased.…”

Table 3_Global, region and country burden of osteoarthritis at different sites in middle-aged and elderly populations from 1990 to 2021: a systematic analysis of the 2021 global bu... by Guoxin Huang (5775458)

“…From 1990 to 2021, the inequality in overall OA burden between countries had decreased. The absolute inequality gap for hand OA had narrowed the most significantly (45.3%), which followed by knee OA (11.9%), while the inequality gap for hip OA has slightly increased.…”

Data Sheet 1_Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatic... by Yongjing Li (3821944)

“…Additionally, β-catenin knockdown led to an upregulation of CASP7 expression, whereas activation of the Wnt/β-catenin signaling pathway reduced CASP7 protein levels. ZZF decreases the activity of the Wnt/β-catenin signaling pathway by decreasing β-catenin transcription and nuclear localization.…”

Table 3_Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, ne... by Yongjing Li (3821944)

“…Additionally, β-catenin knockdown led to an upregulation of CASP7 expression, whereas activation of the Wnt/β-catenin signaling pathway reduced CASP7 protein levels. ZZF decreases the activity of the Wnt/β-catenin signaling pathway by decreasing β-catenin transcription and nuclear localization.…”

Table 1_Global, region and country burden of osteoarthritis at different sites in middle-aged and elderly populations from 1990 to 2021: a systematic analysis of the 2021 global bu... by Guoxin Huang (5775458)

“…From 1990 to 2021, the inequality in overall OA burden between countries had decreased. The absolute inequality gap for hand OA had narrowed the most significantly (45.3%), which followed by knee OA (11.9%), while the inequality gap for hip OA has slightly increased.…”

DataSheet1_Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats.docx by Xing Wang (154377)

“…Besides, DPDS not only improved dyslipidemia in STZ diabetic rats, but also enhanced the activities of antioxidant enzymes, decreased the level of MDA in serum and kidney, and regulated the expression of proteins related to the Nrf2/Keap1 signaling pathway in the kidney. …”