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significant changes » significant challenge (Expand Search)
greatest decrease » treatment decreased (Expand Search), greater increase (Expand Search)
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10061
Table 1_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.xlsx
Published 2025“…The intervention also restored gut barrier function by upregulating mucins, goblet cell counts, and tight junction proteins (ZO-1, occludin, and claudin-1) in colonic tissue, along with reducing serum lipopolysaccharide (LPS) levels. Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”
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10062
Table 1_Weizmannia coagulans BC99 regulates oxidative stress and serum metabolic pathways to improve allergic rhinitis: a randomized, double-blind, placebo-controlled trial.docx
Published 2025“…Furthermore, BC99 supplementation significantly decreased serum IgA, complement C3, EOS, and MDA levels (p < 0.05) while enhancing antioxidant capacity (increased GSH, stabilized SOD). …”
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10063
Image 4_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif
Published 2025“…The intervention also restored gut barrier function by upregulating mucins, goblet cell counts, and tight junction proteins (ZO-1, occludin, and claudin-1) in colonic tissue, along with reducing serum lipopolysaccharide (LPS) levels. Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”
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10064
Rutin attenuates iron overload induced-ferroptosis in rats’ heart tissue
Published 2025“…After rutin treatment, our results revealed that TIBC, ferritin, transferrin, hepicidin, MDA&NO were significantly decreased, while GSH level and GPx&SOD activities were significantly increased. …”
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10065
Neurodevelopmental deposition of H2AK119ub within acetylated euchromatin.
Published 2025“…<b>(G)</b> Log<sub>2</sub>-log<sub>2</sub> plot comparing changes in H2AK119ub and H3K27ac within H3K27ac peak regions detected in the late cerebellum. …”
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10066
Table 1_Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease st...
Published 2025“…The disease burden attributable to insufficient fruit intake (51,210 deaths, 12,497,75 DALYs) was significantly higher than that from inadequate vegetable intake (17,176 deaths, 4,203,09 DALYs). …”
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10067
Table 1_LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis.docx
Published 2025“…NEAT1 knockdown inhibited cell migration, enhanced epithelial barrier integrity, and reversed EMT-associated cytoskeletal remodeling. E-cadherin levels increased, while N-cadherin and vimentin decreased. …”
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10068
Table 2_LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis.docx
Published 2025“…NEAT1 knockdown inhibited cell migration, enhanced epithelial barrier integrity, and reversed EMT-associated cytoskeletal remodeling. E-cadherin levels increased, while N-cadherin and vimentin decreased. …”
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10069
Image1_Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model.jpeg
Published 2024“…Furthermore, DEX treatment reduced the expression levels of a GABA-synthesizing enzyme (GAD67), Reelin, calcium-binding proteins (parvalbumin and calretinin) and neuropeptides co-expressed in GABAergic neurons (somatostatin, neuropeptide Y and vasoactive intestinal peptide) in the PFC were reduced after 21 days of DEX treatment; these reductions were accompanied by decreases in brain size and cerebral cortex thickness.…”
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10070
Table 4_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xlsx
Published 2025“…The analysis reveals that ESG performance significantly alleviates CEI. In addition, CPU weakens the efficiency of ESG initiatives in decreasing CEI due to regulatory unpredictability, while the digital economy’s expansion, although innovative, may exacerbate CEI in regions dependent on fossil fuels. …”
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10071
Table 6_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xlsx
Published 2025“…The analysis reveals that ESG performance significantly alleviates CEI. In addition, CPU weakens the efficiency of ESG initiatives in decreasing CEI due to regulatory unpredictability, while the digital economy’s expansion, although innovative, may exacerbate CEI in regions dependent on fossil fuels. …”
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10072
Table 5_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xlsx
Published 2025“…The analysis reveals that ESG performance significantly alleviates CEI. In addition, CPU weakens the efficiency of ESG initiatives in decreasing CEI due to regulatory unpredictability, while the digital economy’s expansion, although innovative, may exacerbate CEI in regions dependent on fossil fuels. …”
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10073
Table 2_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xls
Published 2025“…The analysis reveals that ESG performance significantly alleviates CEI. In addition, CPU weakens the efficiency of ESG initiatives in decreasing CEI due to regulatory unpredictability, while the digital economy’s expansion, although innovative, may exacerbate CEI in regions dependent on fossil fuels. …”
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10074
Table 3_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xlsx
Published 2025“…The analysis reveals that ESG performance significantly alleviates CEI. In addition, CPU weakens the efficiency of ESG initiatives in decreasing CEI due to regulatory unpredictability, while the digital economy’s expansion, although innovative, may exacerbate CEI in regions dependent on fossil fuels. …”
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10075
Table 1_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xls
Published 2025“…The analysis reveals that ESG performance significantly alleviates CEI. In addition, CPU weakens the efficiency of ESG initiatives in decreasing CEI due to regulatory unpredictability, while the digital economy’s expansion, although innovative, may exacerbate CEI in regions dependent on fossil fuels. …”
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10076
DataSheet1_The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner.docx
Published 2024“…</p>Results<p>Nebivolol treatment decreased IL-17A and IFN-γ secretion by activated memory Th cells and elevated IL-4 levels. …”
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10077
Additional data for optogenetic activation of dFB<sup>VGlutՈ84C10</sup> and dFB<sup>ChATՈ84C10</sup> neurons.
Published 2025“…Two-way repeated measures ANOVA followed by Sidak’s multiple comparisons test found that daytime sleep bout numbers are significantly increased in <i>VGlut-AD; 84C10-DBD>CsChrimson</i> and significantly decreased in <i>84C10-AD; ChAT-DBD>CsChrimson</i> female flies that are stimulated with 627 nm LEDs. n.s. = not significant, **<i>P</i> < 0.01, ****<i>P</i> < 0.0001. …”
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10078
Data Sheet 1_Global, regional, and national epidemiology of otitis media in children from 1990 to 2021.docx
Published 2025“…Key risk factors identified include secondhand smoke, particulate matter pollution, low birth weight, and short gestation. Additionally, a significant inverse association was found between the SDI and the burden of OM, with age-standardized DALY rates decreasing markedly as SDI increased.…”
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10079
Table 1_Association between higher estimated glucose disposal rate and reduced prevalence of hyperuricemia and gout.docx
Published 2025“…Compared to participants with eGDR < 4 mg/kg/min, those with eGDR levels of 4–6, 6–8, and > 8 mg/kg/min exhibited significantly lower OR values for both HUA and gout. …”
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10080
Data Sheet 1_Distinct gut microbiota and metabolomic profiles in HBV-related liver cirrhosis: insights into disease progression.pdf
Published 2025“…Metabolic analysis showed decreased levels of tocopherol and 21-hydroxypregnenolone, which were strongly linked to the reduced abundance of Alistipes and Lachnospira. …”