CK8 knockdown and ROCK1 inhibitor suppressed rTsSPc-induced disruption of the Caco-2 monolayer and blocked rTsSPc-promoted IIL invasion. حسب Wen Wen Zheng (17721404)

Raw data of Figs 1–6 in this study. حسب Qi Qi Lu (17721401)

"…The results of qPCR and Western blot revealed that rTsSPc significantly up-regulated the expression of Caco-2 cell apoptosis-related proteins (Caspase 3, Caspase 9 and Caspase 8, Bax and Cytochrome c), activated the apoptosis pathway, and thereby induced Caco-2 apoptosis. rTsSPc bound and interacted with PGAM5 receptor in Caco-2 cells and induced apoptosis, reduced the tight junctions (TJs) expression levels and damaged the Caco-2 monolayer integrity and barrier function, and promoted larval invasion. …"

Data Sheet 1_Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway.pdf حسب figshare admin frontiersin (4545187)

"…Additionally, the Cyn intervention group showed significant improvements in both the intestinal barrier structure (elevated tight junction protein levels and proper localization) and function (reduced serum FD4 levels, increased intestinal TEER, and decreased bacterial translocation rates in mesenteric lymph nodes [MLNs] and livers). …"