Table 5_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx by Jiayin Gong (18594817)

“…In contrast, Gamma-proteobacteria and Oxalobacter demonstrated bidirectional mediation: via glutamine conjugate of C₆H₁₀O₂(2) and cerotoylcarnitine (C₂₆) (P = 0.026 and P = 0.033, respectively); while these pathways were protective in mediation, higher abundances were associated with increased risk of generalized epilepsy. Notably, no significant mediators were identified for epilepsy or focal epilepsy. …”

Table 1_Emerging cardiovascular toxicity associated with CDK4/6 inhibitors: real-world insights from the FDA adverse event reporting system.xlsx by Wensheng Liu (205723)

“…Disproportionality analysis revealed that Abemaciclib was significantly increased signal of venous thromboembolism (ROR = 2.57 [2.24-2.96]), whereas cardiac arrhythmia (ROR = 2.51 [2.13-2.96]) and torsade de pointes/QT prolongation (ROR = 5.7 [5-6.5]) were showed significantly disproportionate for ribociclib. …”

Table 4_Emerging cardiovascular toxicity associated with CDK4/6 inhibitors: real-world insights from the FDA adverse event reporting system.xlsx by Wensheng Liu (205723)

“…Disproportionality analysis revealed that Abemaciclib was significantly increased signal of venous thromboembolism (ROR = 2.57 [2.24-2.96]), whereas cardiac arrhythmia (ROR = 2.51 [2.13-2.96]) and torsade de pointes/QT prolongation (ROR = 5.7 [5-6.5]) were showed significantly disproportionate for ribociclib. …”

Table 3_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx by Jiayin Gong (18594817)

“…In contrast, Gamma-proteobacteria and Oxalobacter demonstrated bidirectional mediation: via glutamine conjugate of C₆H₁₀O₂(2) and cerotoylcarnitine (C₂₆) (P = 0.026 and P = 0.033, respectively); while these pathways were protective in mediation, higher abundances were associated with increased risk of generalized epilepsy. Notably, no significant mediators were identified for epilepsy or focal epilepsy. …”

Table 1_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx by Jiayin Gong (18594817)

“…In contrast, Gamma-proteobacteria and Oxalobacter demonstrated bidirectional mediation: via glutamine conjugate of C₆H₁₀O₂(2) and cerotoylcarnitine (C₂₆) (P = 0.026 and P = 0.033, respectively); while these pathways were protective in mediation, higher abundances were associated with increased risk of generalized epilepsy. Notably, no significant mediators were identified for epilepsy or focal epilepsy. …”

Table 3_Emerging cardiovascular toxicity associated with CDK4/6 inhibitors: real-world insights from the FDA adverse event reporting system.xlsx by Wensheng Liu (205723)

“…Disproportionality analysis revealed that Abemaciclib was significantly increased signal of venous thromboembolism (ROR = 2.57 [2.24-2.96]), whereas cardiac arrhythmia (ROR = 2.51 [2.13-2.96]) and torsade de pointes/QT prolongation (ROR = 5.7 [5-6.5]) were showed significantly disproportionate for ribociclib. …”

Table 2_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx by Jiayin Gong (18594817)

“…In contrast, Gamma-proteobacteria and Oxalobacter demonstrated bidirectional mediation: via glutamine conjugate of C₆H₁₀O₂(2) and cerotoylcarnitine (C₂₆) (P = 0.026 and P = 0.033, respectively); while these pathways were protective in mediation, higher abundances were associated with increased risk of generalized epilepsy. Notably, no significant mediators were identified for epilepsy or focal epilepsy. …”

Table 1_Impact of individualized tidal volume strategies on intraoperative lung protection and inflammatory markers in laparoscopic cholecystectomy: a randomized controlled trial.d... by Xin Wang (91924)

“…However, the increases in these inflammatory markers were significantly greater in Group C than in Group T (p < 0.05). …”

Data Sheet 1_Level of discharge readiness and influencing factors in ischaemic stroke patients: a descriptive, cross-sectional study.doc by Xiaolu Bai (11543595)

“…Statistical analyses were performed using SPSS 26.0, with significant results visualised in GraphPad Prism 9.0. …”

Table 6_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx by Jiayin Gong (18594817)

“…In contrast, Gamma-proteobacteria and Oxalobacter demonstrated bidirectional mediation: via glutamine conjugate of C₆H₁₀O₂(2) and cerotoylcarnitine (C₂₆) (P = 0.026 and P = 0.033, respectively); while these pathways were protective in mediation, higher abundances were associated with increased risk of generalized epilepsy. Notably, no significant mediators were identified for epilepsy or focal epilepsy. …”

Table 4_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx by Jiayin Gong (18594817)

“…In contrast, Gamma-proteobacteria and Oxalobacter demonstrated bidirectional mediation: via glutamine conjugate of C₆H₁₀O₂(2) and cerotoylcarnitine (C₂₆) (P = 0.026 and P = 0.033, respectively); while these pathways were protective in mediation, higher abundances were associated with increased risk of generalized epilepsy. Notably, no significant mediators were identified for epilepsy or focal epilepsy. …”

Data Sheet 1_Disproportionality analysis of adverse events associated with pacritinib: a real-world study based on FDA Adverse Event Reporting System (FAERS) database.docx by Huiling Zhang (396342)

“…Common preferred terms were identified, including diarrhea, fatigue, death, nausea, platelet count decreased, and hemoglobin decreased. Notably, 26 off­-label AEs were also identified.…”

Opportunistic analysis of clinically actionable DPYD gene variants in a germline testing cohort in India by Rajdeep Raha (22056304)

“…</p> <p>A total of 95 individuals (5.3%) carried at least one decreased or no function DPYD variant, indicating a significant prevalence of clinically actionable genotypes in this Indian cohort. …”

Data Sheet 1_Peers are as persuasive as experts in reducing willingness to pay for sugary foods.pdf by Nina Arzumanyan (22759610)

“…</p>Results<p>All audio interventions significantly decreased participants’ WTP for sugar-containing products compared to sugar-free products. …”

<b>Keystone taxa and microbial network complexity, rather than diversity, sustain soil multifunctionality along an elevational gradient in a subtropical karst mountain</b> by Weixue Luo (6070040)

“…Notably, the positive effects of network complexity and keystone taxa abundance on soil EMF decreased with increasing threshold levels of EMF, yet keystone taxa abundance retained a significant positive effect even at the highest threshold (75%). …”

Supplementary Material for: Status of inpatients with pediatric epilepsy in children’s hospitals in China (2016–2021) by Wang J. (3112815)

“…The root-mean-square-error between the Inter-Provincial Visits Indexes decreased from 1.70 to 0.90, decreasing significantly (R2=0.8306). …”

DMSO reduction in response to high irradiance exposure from simulated vertical mixing. by Brandon J. McNabb (19337538)

“…Significance is determined by two-tailed Student’s t-tests (*: p < 0.05, **: p < 0.01, n.s.: non-significant). …”

Image 3_CS Ratio is an immune-related prognostic biomarker for cervical cancer.tiff by Peiqin Shi (22130170)

“…The CS Ratio significantly decreased with advancing FIGO stage (P < 0.05). …”

Image 2_CS Ratio is an immune-related prognostic biomarker for cervical cancer.tiff by Peiqin Shi (22130170)

“…The CS Ratio significantly decreased with advancing FIGO stage (P < 0.05). …”

Image 1_CS Ratio is an immune-related prognostic biomarker for cervical cancer.tiff by Peiqin Shi (22130170)

“…The CS Ratio significantly decreased with advancing FIGO stage (P < 0.05). …”