Supplemental Figures حسب Danielle A. Jeffrey (21187329)

"…FXR1 has seven isoforms, including isoforms mostly expressed in skeletal and cardiac tissue, and play a significant role in heart development and function. …"

Image 2_A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma.jpeg حسب Yue Fu (64387)

"…</p>Results<p>The MTS and colony formation assays demonstrated that SMCl significantly decreased the viability of HCC cells. Western blot analysis demonstrated that SMCl effectively suppressed hepatocellular carcinoma proliferation by markedly inhibiting the RAS/RAF/MEK/ERK signaling pathway, with this inhibitory effect exhibiting both time- and concentration-dependent characteristics. …"

Image 6_A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma.jpeg حسب Yue Fu (64387)

"…</p>Results<p>The MTS and colony formation assays demonstrated that SMCl significantly decreased the viability of HCC cells. Western blot analysis demonstrated that SMCl effectively suppressed hepatocellular carcinoma proliferation by markedly inhibiting the RAS/RAF/MEK/ERK signaling pathway, with this inhibitory effect exhibiting both time- and concentration-dependent characteristics. …"

Data_Sheet_1_Analysis of spatial and temporal characteristics and evolution of green total factor productivity in agriculture in the lower Yellow River basin.xlsx حسب Junru He (20158257)

"…The results demonstrate that agricultural carbon emissions in the Lower Yellow River Basin gradually decreased throughout the study period. Furthermore, overall carbon emission efficiency improved, indicating significant potential for further emission reduction. …"

Table 1_The global burden of lead exposure-related ischemic stroke: based on Bayesian age-period-cohort analysis.docx حسب Xiaofang Chen (256976)

"…</p>Results<p>In 2019, lead exposure-related ischemic stroke caused a significant disease burden, with males and middle-aged/older adults disproportionately affected. …"

Table 1_Esmolol improves sepsis outcomes through cardiovascular and immune modulation.docx حسب Da Jing (404219)

"…Background<p>Sepsis poses significant mortality risks. Esmolol, a β1-adrenergic blocker, may improve outcomes through cardiovascular and immune modulation. …"

Data Sheet 1_Enhancing chronic low back pain management: an initial neuroimaging study of a mobile interoceptive attention training.pdf حسب Irina A. Strigo (9745472)

"…</p>Results<p>MyP led to significant decreases in PEG scores overall. Furthermore, MyP responders exhibited increased pain-related activation in key brain regions, including the contralateral posterior insula, bilateral ventral anterior insula, ventral anterior cingulate, dorsolateral prefrontal cortex, and nucleus accumbens. …"

Data Sheet 1_Gut microbiota metabolite acetate mediates free fatty acid receptor 2 expression to alleviate atopic dermatitis.zip حسب Siqi Ye (9350531)

"…Acetate supplementation in AD mice significantly ameliorated 2,4-dinitrobenzene (DNCB)-induced dermatitis, as evidenced by reduced skin lesion severity, lower dermatitis scores, and decreased epidermal thickening. …"

Image 4_The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.tif حسب Zechen Zhang (11702123)

"…C-terminal telopeptide (CTX) showed a small, statistically significant reduction (MD −0.09, 95% CI −0.14 to −0.05) with uncertain clinical relevance. …"

Forest Plots, SROC Curve, and Diagnostic Performance Analyses of ctDNA Biomarkers for Early Pancreatic Cancer Detection. حسب Zeyi Zheng (16879938)

"…E: Deeks’ funnel plot asymmetry test for publication bias assessment. A non-significant p-value (p > 0.05) suggests no evidence of significant publication bias. …"

Table 1_Effects of neutral detergent fiber levels on apparent nutrient digestibility and intestinal microbiota composition and function in forest musk deer.docx حسب Qindan Dai (11056236)

"…The H group exhibited significantly higher (p < 0.05) Chao1 and ACE indices compared to the L group. …"

Table 4_Effect of natural bioactive compounds on growth and welfare in Octopus vulgaris paralarvae.xlsx حسب M. Virginia Martín (6321047)

"…Although enzymatic antioxidant responses such as catalase (CAT) and superoxide dismutase (SOD) were unaffected, glutathione S-transferase (GST) activity significantly decreased in the BCO group, suggesting a reduced need for detoxification due to lower oxidative stress. …"

Data Sheet 1_Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis.zip حسب Dongmei Yuan (291583)

"…<p>Visceral leishmaniasis (VL), the most severe form of leishmaniasis, remains a significant public health concern that cannot be overlooked in underdeveloped regions. …"

Supplementary file 1_Flourishing as a highly sensitive person: a mixed method study on the role of nature connectedness and chaotic home environment.docx حسب Susan Carroll (17468)

"…Participants reported significant benefits from nature.</p>Discussion<p>Overall, the results showed that connecting with nature significantly contributes to flourishing in highly sensitive individuals, particularly in middle to older age. …"

Image 2_The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.tif حسب Zechen Zhang (11702123)

"…C-terminal telopeptide (CTX) showed a small, statistically significant reduction (MD −0.09, 95% CI −0.14 to −0.05) with uncertain clinical relevance. …"

Image 5_A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma.jpeg حسب Yue Fu (64387)

"…</p>Results<p>The MTS and colony formation assays demonstrated that SMCl significantly decreased the viability of HCC cells. Western blot analysis demonstrated that SMCl effectively suppressed hepatocellular carcinoma proliferation by markedly inhibiting the RAS/RAF/MEK/ERK signaling pathway, with this inhibitory effect exhibiting both time- and concentration-dependent characteristics. …"

Image 3_The global burden of lead exposure-related ischemic stroke: based on Bayesian age-period-cohort analysis.png حسب Xiaofang Chen (256976)

"…</p>Results<p>In 2019, lead exposure-related ischemic stroke caused a significant disease burden, with males and middle-aged/older adults disproportionately affected. …"

<i>Neisseria</i> species on the tonsillar surface predicts favorable clinical outcomes in patients with Immunoglobulin A nephropathy who underwent tonsillectomy حسب Ryosuke Sato (615801)

"…However, there were no significant differences in the clinical course, except for renal survival rates, between patients with and without <i>Neisseria</i> sp. at the tonsillar center. …"

Data Sheet 2_Age-period-cohort analysis of global, regional, and national trends in laryngeal Cancer among older adults, 1990–2021: insights from the 2021 global burden of disease... حسب Zhe Sun (328682)

"…</p>Results<p>From 1990 to 2021, the global ASIR of laryngeal cancer among older adults decreased from 15.16 to 12.25 per 100,000, with significant shifts in trends observed in 1995, 2002, and 2007. …"

Identifying hotspots of urbanization and agricultural growth: a spatio-temporal analysis of land use dynamics in Tolga, Algeria (1994–2024) حسب Mohamed Akram Eddine Ben Ratmia (21662098)

"…<p>Land use and land cover (LULC) changes driven by urbanization and agricultural expansion pose significant challenges to biodiversity, water resources, and sustainable development, particularly in arid and semi-arid regions. …"